Evidence map›Paper›PMID 25283790›Full record

ArticleJournal of child psychology and psychiatry, and allied disciplines2015

Sex differences in ADHD symptom severity.

Anne B Arnett, Bruce F Pennington, Erik G Willcutt, John C DeFries, Richard K Olson

Abstract read
In one paragraph

Article in Journal of child psychology and psychiatry, and allied disciplines, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 118 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
118citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

118 citing papers in PubMed, 6 syntheses or guidelines pooled it.

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58 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Anne B ArnettDepartment of Psychology, University of Denver, Denver, CO, USA.
Bruce F PenningtonDepartment of Psychology, University of Denver, Denver, CO, USA.
Erik G WillcuttPsychology and Neuroscience, University of Colorado at Boulder, Boulder, CO, USA.
John C DeFriesInstitute for Behavioral Genetics, University of Colorado at Boulder, Boulder, CO, USA.
Richard K OlsonInstitute for Behavioral Genetics, University of Colorado at Boulder, Boulder, CO, USA.

Funding

VALIDITY OF SUBTYPES OF ADHDP50HD027802 · NICHD · UNIVERSITY OF COLORADO AT BOULDER · PI ERIK G WILLCUTT · 1990 to 2026
$44.9M
Etiology and Neuropsychology of Math, Reading, ADHD, and their CovariationR01HD068728 · NICHD · UNIVERSITY OF COLORADO · PI PETRILL, STEPHEN A., WILLCUTT, ERIK G · 2011 to 2015
$3.0M
Translational Study of the Development of Behavior Dysregulation in YouthF31MH099749 · NIMH · UNIVERSITY OF DENVER (COLORADO SEMINARY) · PI ARNETT, ANNE BERNARD · 2013 to 2014
$85k
NICHD NIH HHS HD27802NICHD NIH HHS P50 HD027802NICHD NIH HHS R01 HD068728NIMH NIH HHS F31 MH099749
6 · The paper itself

Abstract

backgroundMales show higher rates of attention deficit hyperactivity disorder (ADHD) than do females. Potential explanations include genuine etiological differences or artifact.

methods2,332 twin and sibling youth participated in behavioral and cognitive testing. Partially competing models of symptom severity distribution differences, the mean difference, and variance difference models, were tested within a randomly selected subsample. The Delta method was used to test for mediation of sex differences in ADHD symptom severity by processing speed, inhibition and working memory.

resultsThe combined mean difference and variance difference models fully explained the sex difference in ADHD symptom severity. Cognitive endophenotypes mediated 14% of the sex difference effect.

conclusionsThe sex difference in ADHD symptom severity is valid and may be due to differing genetic and cognitive liabilities between the sexes.

Indexed as

EndophenotypesAdolescentAdultAttention Deficit Disorder with HyperactivityChildDiseases in TwinsFemaleHumansMaleSeverity of Illness IndexSex FactorsYoung AdultADHDcognitive developmentgender differencemediationneuropsychology

Identifiers

PMID25283790
PMCPMC4385512

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.