Evidence map›Paper›PMID 25283728›Full record

ReviewResearch in microbiology2015

Clostridium perfringens type A-E toxin plasmids.

John C Freedman, James R Theoret, Jessica A Wisniewski, Francisco A Uzal, Julian I Rood, Bruce A McClane

Abstract readReview
In one paragraph

Review in Research in microbiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 63 citations in OpenAlex.

  1. Review
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  9. Review
  10. Article
  11. Biology · 2022
    Article
  12. Intra-species diversity ofFrontiers in microbiology · 2022
    Article
  13. Article
  14. Article
  15. Large Clostridial Toxins: Mechanisms and Roles in Disease.Microbiology and molecular biology reviews : MMBR · 2021
    Review
  16. Article
  17. BMJ case reports · 2021
    Article
  18. Article
  19. Characterization ofIranian journal of veterinary research · 2021
    Article
  20. Genome Sequence Analysis ofFrontiers in microbiology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

John C FreedmanDepartment of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
James R TheoretDepartment of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Jessica A WisniewskiDepartment of Microbiology, Monash University, Clayton, Victoria, Australia.
Francisco A UzalCalifornia Animal Health and Food Safety Laboratory, San Bernadino Branch, School of Veterinary Medicine, University of California-Davis, San Bernadino, CA, USA.
Julian I RoodDepartment of Microbiology, Monash University, Clayton, Victoria, Australia.
Bruce A McClaneDepartment of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. Electronic address: bamcc@pitt.edu.
University of Pittsburgh · USMonash University · AUCalifornia State University, San Bernardino · US

Funding

Vaccine strategy for broad spectrum protection agains non-typhoidal salmonellU54AI057168 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI WHITE, JUDITH M. · 2003 to 2013
$91.5M
Immunology of Infectious DiseaseT32AI060525 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI JoAnne L. Flynn · 2005 to 2026
$5.3M
Clostridium perfringens Type B-D Virulence PlasmidsR01AI056177 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MC CLANE, BRUCE A, ROOD, JULIAN · 2003 to 2013
$3.8M
Mechanisms of Action of C. Perfringens EnterotoxinR37AI019844 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MC CLANE, BRUCE A · 2005 to 2014
$3.0M
NIAID NIH HHS 2U54AI57168-09NIAID NIH HHS R01 AI056177NIAID NIH HHS R01AI056177-09NIAID NIH HHS R37 AI019844NIAID NIH HHS R37AI19844-30NIAID NIH HHS T32 AI060525NIAID NIH HHS U54 AI057168
6 · The paper itself

Abstract

Clostridium perfringens relies upon plasmid-encoded toxin genes to cause intestinal infections. These toxin genes are associated with insertion sequences that may facilitate their mobilization and transfer, giving rise to new toxin plasmids with common backbones. Most toxin plasmids carry a transfer of clostridial plasmids locus mediating conjugation, which likely explains the presence of similar toxin plasmids in otherwise unrelated C. perfringens strains. The association of many toxin genes with insertion sequences and conjugative plasmids provides virulence flexibility when causing intestinal infections. However, incompatibility issues apparently limit the number of toxin plasmids maintained by a single cell.

Indexed as

PlasmidsAdaptation, BiologicalBacterial ToxinsClostridium perfringensConjugation, GeneticDNA Transposable ElementsGene Transfer, HorizontalVirulence FactorsBacterial ToxinsDNA Transposable ElementsVirulence FactorsClostridiaConjugationGastrointestinal diseasePlasmid-encoded toxinPlasmid evolution

Identifiers

PMID25283728
PMCPMC4383721
OpenAlexW2055486959

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.