Evidence map›Paper›PMID 25283571›Full record

ReviewLancet (London, England)2014

Fertility preservation in women with cancer.

Michel De Vos, Johan Smitz, Teresa K Woodruff

Erratum issued Registry-linked trialAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Lancet (London, England), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT04586686 (Combining Interventions of Fertility Preservation to Mitigate Fertility Loss After), which is not on this map. Cited by 145 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
145citing papers in PubMed, 4 pooled it
35.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04586686 naunknown statusnot on this mapstarted 2022, after this paper: background citation

Combining Interventions of Fertility Preservation to Mitigate Fertility Loss After

TypeinterventionalSponsorUniversitair Ziekenhuis BrusselRan2022 to 2024Enrolled41ConditionsBreast Cancer FemaleArmsOvarian biopsy via laparoscopy, Transvaginal oocyte retrieval
3 · Its place in the literature

Who cites it

145 citing papers in PubMed, 4 syntheses or guidelines pooled it, 313 citations in OpenAlex.

  1. Guideline
  2. Management of Primary Ovarian Insufficiency Symptoms in Survivors of Childhood and Adolescent Cancer.Journal of the National Comprehensive Cancer Network : JNCCN · 2018
    Pooled it
  3. Pooled it
  4. Pooled it
  5. Trial
  6. Trial
  7. Trial
  8. Review
  9. Article
  10. Review
  11. Review
  12. Review
  13. Article
  14. Review
  15. Cancer therapy and reproductive impact.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2025
    Article
  16. Article
  17. Review
  18. Oncofertility in Prepubertal Girls: A Qualitative Study of Canadian and French Pediatric Oncologists' Perspectives on Ovarian Tissue Cryopreservation.The Journal of law, medicine & ethics : a journal of the American Society of Law, Medicine & Ethics · 2025
    Article
  19. Article
  20. Review

85 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Michel De VosCentre for Reproductive Medicine, UZ Brussel, Brussels, Belgium. Electronic address: mdevos@uzbrussel.be.
Johan SmitzLaboratory of Clinical Chemistry and Radioimmunology, UZ Brussel, Brussels, Belgium.
Teresa K WoodruffFeinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Northwestern University · US

Funding

Project 3: Medically-based Protection of the Ovarian Reserve Against Anti-CancerP50HD076188 · NICHD · NORTHWESTERN UNIVERSITY AT CHICAGO · PI WOODRUFF, TERESA K · 2014 to 2017
$6.2M
Project 3: Medically-based Protection of the Ovarian Reserve Against Anti-CancerU54HD076188 · NICHD · NORTHWESTERN UNIVERSITY AT CHICAGO · PI WOODRUFF, TERESA K · 2013 to 2013
$1.6M
NICHD NIH HHS P50 HD076188NICHD NIH HHS U54 HD076188
6 · The paper itself

Abstract

Enhanced long-term survival rates of young women with cancer and advances in reproductive medicine and cryobiology have culminated in an increased interest in fertility preservation methods in girls and young women with cancer. Present data suggest that young patients with cancer should be referred for fertility preservation counselling quickly to help with their coping process. Although the clinical application of novel developments, including oocyte vitrification and oocyte maturation in vitro, has resulted in reasonable success rates in assisted reproduction programmes, experience with these techniques in the setting of fertility preservation is in its infancy. It is hoped that these and other approaches, some of which are still regarded as experimental (eg, ovarian tissue cryopreservation, pharmacological protection against gonadotoxic agents, in-vitro follicle growth, and follicle transplantation) will be optimised and become established within the next decade. Unravelling the complex mechanisms of activation and suppression of follicle growth will not only expand the care of thousands of women diagnosed with cancer, but also inform the care of millions of women confronted with reduced reproductive fitness because of ageing.

Indexed as

Antineoplastic AgentsCounselingCryopreservationFemaleFertility PreservationHumansInfertility, FemaleIn Vitro Oocyte Maturation TechniquesNeoplasmsReproductive Techniques, AssistedAntineoplastic Agents

Identifiers

PMID25283571
PMCPMC4270060
OpenAlexW1965380539

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.