Evidence map›Paper›PMID 25283350›Full record

Trial reportArchives of physical medicine and rehabilitation2015

Safety of primed repetitive transcranial magnetic stimulation and modified constraint-induced movement therapy in a randomized controlled trial in pediatric hemiparesis.

Bernadette T Gillick, Linda E Krach, Tim Feyma, Tonya L Rich, Kelli Moberg, Jeremiah Menk, Jessica Cassidy, Teresa Kimberley, James R Carey

Registry-linked trialOpen access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Archives of physical medicine and rehabilitation, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02743728 (Perinatal Stroke), which is not on this map. Cited by 25 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 2 pooled it
2.8field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02743728 completednot on this mapstarted 2016, after this paper: background citation

Perinatal Stroke: Understanding Brain Reorganization Through Infant Neuroimaging and Neuromodulation

TypeobservationalSponsorUniversity of MinnesotaRan2016 to 2022Enrolled20ConditionsStroke, HemiparesisArmsMagnetic Resonance Imaging, Transcranial Magnetic Stimulation, General Movement Assessment
3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 40 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Transcranial direct current stimulation and constraint-induced therapy in cerebral palsy: A randomized, blinded, sham-controlled clinical trial.European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society · 2018
    Trial
  4. Trial
  5. Trial
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Review
  13. Review
  14. Review
  15. Article
  16. Article
  17. Article
  18. Understanding Brain Reorganization in Infants With Perinatal Stroke Through Neuroexcitability and Neuroimaging.Pediatric physical therapy : the official publication of the Section on Pediatrics of the American Physical Therapy Association · 2017
    Article
  19. Review
  20. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Bernadette T GillickDepartment of Physical Medicine and Rehabilitation, University of Minnesota Medical School, Minneapolis, MN. Electronic address: gillick@umn.edu.
Linda E KrachDepartment of Physical Medicine and Rehabilitation, University of Minnesota Medical School, Minneapolis, MN; Gillette Children's Specialty Healthcare, St Paul, MN.
Tim FeymaGillette Children's Specialty Healthcare, St Paul, MN.
Tonya L RichGillette Children's Specialty Healthcare, St Paul, MN.
Kelli MobergGillette Children's Specialty Healthcare, St Paul, MN.
Jeremiah MenkUniversity of Minnesota Clinical and Translational Science Institute Biostatistical Design and Analysis Center, Minneapolis, MN.
Jessica CassidyDepartment of Physical Medicine and Rehabilitation, University of Minnesota Medical School, Minneapolis, MN.
Teresa KimberleyDepartment of Physical Medicine and Rehabilitation, University of Minnesota Medical School, Minneapolis, MN.
James R CareyDepartment of Physical Medicine and Rehabilitation, University of Minnesota Medical School, Minneapolis, MN.
Gillette Children's Specialty Healthcare · USUniversity of Minnesota Medical Center · USUniversity of Minnesota · US

Funding

University of Minnesota Clinical and Translational Science Institute (UMN CTSI)UL1TR000114 · NCATS · UNIVERSITY OF MINNESOTA · PI BLAZAR, BRUCE R · 2012 to 2015
$35.0M
UNIVERSITY OF MINNESOTA CLINICAL AND TRANSLATIONAL SCIENCE INSTITUTE (UMN CTSI)UL1RR033183 · NCRR · UNIVERSITY OF MINNESOTA · PI BLAZAR, BRUCE R · 2011 to 2011
$8.9M
NMR Imaging and SpectroscopyP41EB015894 · NIBIB · UNIVERSITY OF MINNESOTA · PI UGURBIL, KAMIL · 2012 to 2017
$8.4M
University of Minnesota Clinical and Translational Science Institute (UMN CTSI)KL2TR000113 · NCATS · UNIVERSITY OF MINNESOTA · PI BLAZAR, BRUCE R · 2012 to 2015
$5.4M
Pediatric Hemiplegia: Synergistic Treatment using rTMS and CITRC1HD063838 · NICHD · UNIVERSITY OF MINNESOTA · PI CAREY, JAMES R, MCLAUGHLIN, JOHN FRANCIS · 2009 to 2010
$990k
NCATS NIH HHS 8 UL1 TR000114-02NCATS NIH HHS KL2 TR000113NCATS NIH HHS UL1 TR000114NCRR NIH HHS 1UL1RR033183-01NCRR NIH HHS UL1 RR033183NIBIB NIH HHS P41 EB015894NICHD NIH HHS 1 RC1HD063838-01NICHD NIH HHS RC1 HD063838
6 · The paper itself

Abstract

objectiveTo investigate the safety of combining a 6-Hz primed low-frequency repetitive transcranial magnetic stimulation (rTMS) intervention in the contralesional hemisphere with a modified constraint-induced movement therapy (mCIMT) program in children with congenital hemiparesis.

designPhase 1 randomized, double-blinded, placebo-controlled pretest/posttest trial.

settingUniversity academic facility and pediatric specialty hospital.

participantsSubjects (N = 19; age range, 8-17 y) with congenital hemiparesis caused by ischemic stroke or periventricular leukomalacia. No subject withdrew because of adverse events. All subjects included completed the study.

interventionsSubjects were randomized to 1 of 2 groups: either real rTMS plus mCIMT (n = 10) or sham rTMS plus mCIMT (n = 9).

main outcome measuresAdverse events, physician assessment, ipsilateral hand function, stereognosis, cognitive function, subject report of symptoms assessment, and subject questionnaire.

resultsNo major adverse events occurred. Minor adverse events were found in both groups. The most common events were headaches (real: 50%, sham: 89%; P = .14) and cast irritation (real: 30%, sham: 44%; P = .65). No differences between groups in secondary cognitive and unaffected hand motor measures were found.

conclusionsPrimed rTMS can be used safely with mCIMT in congenital hemiparesis. We provide new information on the use of rTMS in combination with mCIMT in children. These findings could be useful in research and future clinical applications in advancing function in congenital hemiparesis.

Indexed as

Physical Therapy ModalitiesAdolescentChildCognitionFemaleHandHumansMaleParesisStereognosisStrokeTranscranial Magnetic StimulationPediatricsRehabilitationSafetyStrokeTranscranial magnetic stimulation

Identifiers

PMID25283350
PMCPMC4380609
OpenAlexW2086313140

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.