ArticleJournal of gastroenterology2015
Pancreatic congestion in liver cirrhosis correlates with impaired insulin secretion.
Article in Journal of gastroenterology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 22 citations in OpenAlex.
- Liver resection volume-dependent pancreatic strain following living donor hepatectomy.Scientific reports · 2024Article
- Intravoxel incoherent motion diffusion-weighted imaging for evaluating the pancreatic perfusion in cirrhotic patients.Abdominal radiology (New York) · 2024Article
- Effects of Liver Fibrosis on Islet Function in Patients with Chronic Hepatitis B Complicated with Impaired Fasting Glucose.International journal of general medicine · 2023Article
- Combined evaluation of Fibrosis-4 index and fatty liver for stratifying the risk for diabetes mellitus.Journal of diabetes investigation · 2022Article
- Hepatogenous diabetes: Knowledge, evidence, and skepticism.World journal of hepatology · 2022Review
- Heart Failure and Pancreas Exocrine Insufficiency: Pathophysiological Mechanisms and Clinical Point of View.Journal of clinical medicine · 2022Review
- Disorders in Blood Circulation As a Probable Cause of Death in Dogs Infected withJournal of veterinary research · 2021Article
- Salvianolate Reduces Glucose Metabolism Disorders in Dimethylnitrosamine-Induced Cirrhotic Rats.Chinese journal of integrative medicine · 2018Article
- Interrelationship between insulin resistance and portal haemodynamic abnormality in cirrhosis.International journal of medical sciences · 2017Article
- Non-invasive assessment of portal hypertension and liver fibrosis using contrast-enhanced ultrasonography.Hepatology international · 2016Review
- Hepatogenous Diabetes - Let us Shun the Neglect!Indian journal of endocrinology and metabolismArticle
- Insulin Resistance and Beta Cell Function in Hepatogenous Diabetes.Indian journal of endocrinology and metabolismArticle
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAlthough impaired glucose tolerance is common in cirrhosis, this condition's pathogenesis remains undefined. This study aimed to clarify pathogenesis related to the pancreas in cirrhotic patients, and to evaluate associations between insulin secretion and pancreatic congestion due to portal hypertension.
methodsPancreatic perfusion parameters were analyzed by dynamic contrast-enhanced ultrasound (CE-US) in 41 patients (20 cirrhotic, 21 non-cirrhotic; age, 67.9 ± 13.3; female, 19), and prospectively compared to delta C-peptide immunoreactivity (ΔCPR). In a separate study, a retrospective chart review with human autopsy specimens was conducted, and vessels and islets of the pancreas were analyzed in 43 patients (20 cirrhotic, 23 controls; age, 71.5 ± 11.6; female, 15).
resultsIn the CE-US study, the clinical characteristics indicative of portal hypertension (e.g., ascites and varices) had significantly higher incidences in the cirrhotic group than in the control group. Pancreatic drainage times were greater in the cirrhotic group (p < 0.0001), and had a significant negative correlation with ΔCPR (R = 0.42, p = 0.0069). In the histopathological study, the islets were enlarged in the cirrhotic group (p < 0.0001). However, the percentage of insulin-positive area per islet was decreased in the cirrhotic group (p < 0.0001), and had a significant negative correlation with the wall thickness of the pancreatic vein (R = 0.63, p < 0.0001).
conclusionsPancreatic congestion was present in cirrhotic patients. Moreover, pancreatic congestion and insulin secretion were significantly correlated. This pathogenesis could be a key factor underlying the development of hepatogenous diabetes in cirrhotic patients.
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