ArticleBioorganic & medicinal chemistry letters2014
Structure-activity relationships of non-opioid [des-Arg(7)]-dynorphin A analogues for bradykinin receptors.
Article in Bioorganic & medicinal chemistry letters, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed, 14 citations in OpenAlex.
- Microiontophoretic Application of Dynorphin in Dental Pain: Excitatory or Inhibitory Effects.Journal of pain research · 2025Article
- Discovery of Stable Non-opioid Dynorphin A Analogues Interacting at the Bradykinin Receptors for the Treatment of Neuropathic Pain.ACS chemical neuroscience · 2016Article
- Cyclic non-opioid dynorphin A analogues for the bradykinin receptors.Bioorganic & medicinal chemistry letters · 2016Article
- Various modifications of the amphipathic dynorphin A pharmacophore for rat brain bradykinin receptors.Chemical biology & drug design · 2016Article
- Dynorphin A analogs for the treatment of chronic neuropathic pain.Future medicinal chemistry · 2016Review
- Design, synthesis and biological evaluation of multifunctional ligands targeting opioid and bradykinin 2 receptors.Bioorganic & medicinal chemistry letters · 2015Article
- Modification of amphipathic non-opioid dynorphin A analogues for rat brain bradykinin receptors.Bioorganic & medicinal chemistry letters · 2015Article
- Blockade of non-opioid excitatory effects of spinal dynorphin A at bradykinin receptors.Receptors & clinical investigationArticle
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
In our earlier studies, bradykinin receptors (BRs) were identified as a potential target for the neuroexcitatory effects of dynorphin A (Dyn A) in the central nervous system (CNS), and [des-Arg(7)]-Dyn A-(4-11) (6) was discovered as a lead ligand to modulate Dyn A-(2-13) induced neuroexcitatory effects in the CNS as an antagonist. In an effort to gain insights into key structural features of the Dyn A for the BRs, we pursued further structure-activity relationships (SAR) study on the [des-Arg(7)]-Dyn A analogs and confirmed that all of the [des-Arg(7)]-Dyn A analogues showed good binding affinities at the BRs.
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Registered trials
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