Evidence map›Paper›PMID 25282293›Full record

ReviewImmunology and allergy clinics of North America2014

Novel therapeutic strategies for adult obese asthmatics.

Angela L Linderholm, Jennifer M Bratt, Gertrud U Schuster, Amir A Zeki, Nicholas J Kenyon

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Immunology and allergy clinics of North America, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Angela L LinderholmDivision of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, University of California, Davis, 4150 V Street, Suite 3100, Davis, CA, USA.
Jennifer M BrattDivision of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, University of California, Davis, 4150 V Street, Suite 3100, Davis, CA, USA.
Gertrud U SchusterNutrition Department, University of California, Davis, 430 West Health Sciences Drive, Davis, CA, USA; Immunity and Diseases Prevention Unit, Western Human Nutrition Research Center, United States Department of Agriculture (USDA), Agricultural Research Services (ARS), 430 West Health Sciences Drive, Davis, CA, USA.
Amir A ZekiDivision of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, University of California, Davis, 4150 V Street, Suite 3100, Davis, CA, USA.
Nicholas J KenyonDivision of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, University of California, Davis, 4150 V Street, Suite 3100, Davis, CA, USA. Electronic address: njkenyon@ucdavis.edu.

Funding

TRAINING IN COMPARATIVE LUNG BIOLOGY AND MEDICINET32HL007013 · NHLBI · UNIVERSITY OF CALIFORNIA DAVIS · PI Elena Goncharova, Nicholas J. KENYON · 1985 to 2026
$10.1M
L-arginine as a therapy in severe asthmaR01HL105573 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI KENYON, NICHOLAS J. · 2012 to 2016
$1.9M
PROTECTIVE ROLE FOR NITRIC OXIDE IN AIRWAY INFLAMMATIONK08HL076415 · NHLBI · UNIVERSITY OF CALIFORNIA DAVIS · PI KENYON, NICHOLAS J. · 2005 to 2009
$617k
The Modulation of Eotaxin Expression by Statins: Implications for Asthma TherapyK08HL114882 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI ZEKI, AMIR A. · 2014 to 2016
$435k
Noninvasive imaging of eosinophilsR21AI097354 · NIAID · UNIVERSITY OF CALIFORNIA AT DAVIS · PI LOUIE, ANGELIQUE Y · 2013 to 2014
$383k
NHLBI NIH HHS HL105573NHLBI NIH HHS K08 HL076415NHLBI NIH HHS K08 HL114882NHLBI NIH HHS R01 HL105573NHLBI NIH HHS T32 HL007013NHLBI NIH HHS T32 HL07013NIAID NIH HHS AI097354NIAID NIH HHS R21 AI097354
6 · The paper itself

Abstract

Asthma is a complex syndrome that affects an estimated 26 million people in the United States but gaps exist in the recognition and management of asthmatic subgroups. This article proposes alternative approaches for future treatments of adult obese asthmatics who do not respond to standard controller therapies, drawing parallels between seemingly disparate therapeutics through their common signaling pathways. How metformin and statins can potentially improve airway inflammation is described and supplements are suggested. A move toward more targeted therapies for asthma subgroups is needed. These therapies address asthma and the comorbidities that accompany obesity and metabolic syndrome to provide the greatest therapeutic potential.

Indexed as

Molecular Targeted TherapyAdenylate KinaseAdultAirway RemodelingArginineAsthmaDietary SupplementsHumansHydroxymethylglutaryl-CoA Reductase InhibitorsInflammation MediatorsMetforminObesityAdenylate KinaseArginineHydroxymethylglutaryl-CoA Reductase InhibitorsInflammation MediatorsMetforminl-ArginineMetforminNitric oxideObesitySevere asthmaStatins

Identifiers

PMID25282293
PMCPMC4185374

What OpenQuestion holds

Texttitle and abstract
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.