Evidence map›Paper›PMID 25282280›Full record

ArticleEnvironmental research2014

Exposure to airborne polycyclic aromatic hydrocarbons during pregnancy and risk of preterm birth.

Amy M Padula, Elizabeth M Noth, S Katharine Hammond, Fred W Lurmann, Wei Yang, Ira B Tager, Gary M Shaw

Abstract read
In one paragraph

Article in Environmental research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed, 1 pooled it
3.7field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 1 synthesis or guideline pooled it, 95 citations in OpenAlex.

  1. Pooled it
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  16. Pregnancy exposure to PMEnvironment international · 2024
    Article
  17. Article
  18. An Exploratory Analysis of Firefighter Reproduction through Survey Data and Biomonitoring.International journal of environmental research and public health · 2023
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Amy M PadulaStanford University, School of Medicine, Department of Pediatrics, Stanford, CA, USA.
Elizabeth M NothUniversity of California, Berkeley, School of Public Health, Division of Environmental Health Sciences, Berkeley, CA, USA.
S Katharine HammondUniversity of California, Berkeley, School of Public Health, Division of Environmental Health Sciences, Berkeley, CA, USA.
Fred W LurmannSonoma Technology, Inc., Petaluma, CA, USA.
Wei YangStanford University, School of Medicine, Department of Pediatrics, Stanford, CA, USA.
Ira B TagerUniversity of California, Berkeley, School of Public Health, Division of Environmental Health Sciences, Berkeley, CA, USA.
Gary M ShawStanford University, School of Medicine, Department of Pediatrics, Stanford, CA, USA.
Stanford University · USUniversity of California, Berkeley · USSonoma Technology (United States) · US

Funding

UC Berkeley/Stanford Children's Enviromental Health CenterP01ES022849 · NIEHS · UNIVERSITY OF CALIFORNIA BERKELEY · PI BALMES, JOHN R · 2013 to 2018
$4.2M
Project 3: Ambient Pollutants/Bioaerosol Effects on Treg FunctionP20ES018173 · NIEHS · UNIVERSITY OF CALIFORNIA BERKELEY · PI HAMMOND, S KATHARINE · 2010 to 2012
$895k
Traffic-related air pollution, social factors and adverse birth outcomesK99ES021470 · NIEHS · STANFORD UNIVERSITY · PI PADULA, AMY MICHELLE · 2013 to 2014
$254k
NIEHS NIH HHS K99 ES021470NIEHS NIH HHS K99ES021470NIEHS NIH HHS L40 ES023163NIEHS NIH HHS P01 ES022849NIEHS NIH HHS P01ES022849NIEHS NIH HHS P20 ES018173NIEHS NIH HHS P20ES018173PHS HHS R21ESO14891
6 · The paper itself

Abstract

backgroundPreterm birth is an important marker of health and has a prevalence of 12-13% in the U.S. Polycyclic aromatic hydrocarbons (PAHs) are a group of organic contaminants that form during the incomplete combustion of hydrocarbons, such as coal, diesel and gasoline. Studies suggest that exposure to PAHs during pregnancy is related to adverse birth outcomes. The aim of this study is to evaluate the association between exposure to PAHs during the pregnancy and preterm birth.

methodsThe study population included births from years 2001 to 2006 of women whose maternal residence was within 20km of the primary monitoring site in Fresno, California. Data in the Fresno area were used to form a spatio-temporal model to assign daily exposure to PAHs with 4, 5, or 6 rings at the maternal residence throughout pregnancy of all of the births in the study area. Gestational age at birth and relevant covariates were extracted from the birth certificate.

resultsWe found an association between PAHs during the last 6 weeks of pregnancy and birth at 20-27 weeks (OR=2.74; 95% CI: 2.24-3.34) comparing the highest quartile to the lower three. The association was consistent when each quartile was compared to the lowest (OR2nd=1.49, 95% CI: 1.08-2.06; OR3rd=2.63, 95% CI:1.93-3.59; OR4th=3.94, 95% CI:3.03-5.12). Inverse associations were also observed for exposure to PAHs during the entire pregnancy and the first trimester and birth at 28-31 weeks and 20-27 weeks.

conclusionAn association between PAH exposure during the 6 weeks before delivery and early preterm birth was observed. However, the inverse association with early preterm birth offers an unclear, and potentially complex, inference of these associations.

Indexed as

Models, BiologicalSeasonsAir PollutantsCaliforniaFemaleHumansMaternal ExposureOdds RatioPolycyclic Aromatic HydrocarbonsPregnancyPremature BirthPrevalenceAir PollutantsPolycyclic Aromatic HydrocarbonsOutdoor air pollutionPolycyclic aromatic hydrocarbonsPregnancyPrematurity

Identifiers

PMID25282280
PMCPMC4262545
OpenAlexW2010430185

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.