SynthesisNature genetics2014
Defining the role of common variation in the genomic and biological architecture of adult human height.
Open access · greenAbstract readMeta-Analysis
In one paragraph
Synthesis in Nature genetics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1,069 papers, 8 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
1,069citing papers in PubMed, 8 pooled it
2.3field-weighted citation impact, top 13% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1,069 citing papers in PubMed, 8 syntheses or guidelines pooled it, 140 citations in OpenAlex.
- Scalable and accurate rare variant meta-analysis with Meta-SAIGE.Nature genetics · 2025Pooled it
- Risk factors for prostate cancer: An umbrella review of prospective observational studies and mendelian randomization analyses.PLoS medicine · 2024Pooled it
- A meta-analysis of genetic and phenotypic diversity of European local pig breeds reveals genomic regions associated with breed differentiation for production traits.Genetics, selection, evolution : GSE · 2023Pooled it
- Boosting the power of genome-wide association studies within and across ancestries by using polygenic scores.Nature genetics · 2023Pooled it
- Overcoming attenuation bias in regressions using polygenic indices.Nature communications · 2023Pooled it
- Meta-analysis of genome-wide association studies of hoarding symptoms in 27,537 individuals.Translational psychiatry · 2022Pooled it
- Genetic and clinical determinants of abdominal aortic diameter: genome-wide association studies, exome array data and Mendelian randomization study.Human molecular genetics · 2022Pooled it
- A multi-population phenome-wide association study of genetically-predicted height in the Million Veteran Program.PLoS genetics · 2022Pooled it
- Ancient DNA and Human Physiology.Physiology (Bethesda, Md.) · 2026Review
- Imputation of fluid intelligence scores reduces ascertainment bias and increases power for analyses of common and rare variants.Nature genetics · 2026Article
- Article
- Shared genetic basis and structure of syndromic and normal facial variation.American journal of human genetics · 2026Article
- ESR1 as a candidate gene for adolescent idiopathic scoliosis pathogenesis in North-West Indian population.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026Article
- Growth-Associated SNPs of theAnimals : an open access journal from MDPI · 2026Article
- Explicitly modeling genetic ancestry to improve polygenic prediction accuracy for height in a large, admixed cohort of US Latinos: Findings from HCHS/SOL.HGG advances · 2026Article
- MIXPRS enables multi-population and multi-method polygenic risk scores using summary statistics.Nature genetics · 2026Article
- Rare protein-coding variation and the genetic architecture of height in >1.4 million individuals.medRxiv : the preprint server for health sciences · 2026Article
- Principled measures and estimates of trait polygenicity.American journal of human genetics · 2026Article
- Private QTLs and the genetic architecture of hierarchical size traits: from body size to sex-specific plasticity.G3 (Bethesda, Md.) · 2026Article
- Combinatorial effects of gene dosage, polygenic background and environment on complex traits.medRxiv : the preprint server for health sciences · 2026Article
1,009 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
449 authors at 20 institutions in 23 countries.
Andrew R WoodGenetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, UK.
Tonu Esko1] Estonian Genome Center, University of Tartu, Tartu, Estonia. [2] Division of Endocrinology, Genetics and Basic and Translational Obesity Research, Boston Children's Hospital, Boston, Massachusetts, USA. [3] Broad Institute of MIT and Harvard University, Cambridge, Massachusetts, USA. [4] Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA.
Jian Yang1] Queensland Brain Institute, University of Queensland, Brisbane, Queensland, Australia. [2] University of Queensland Diamantina Institute, Translation Research Institute, Brisbane, Queensland, Australia.
Sailaja Vedantam1] Division of Endocrinology, Genetics and Basic and Translational Obesity Research, Boston Children's Hospital, Boston, Massachusetts, USA. [2] Broad Institute of MIT and Harvard University, Cambridge, Massachusetts, USA.
Tune H Pers1] Division of Endocrinology, Genetics and Basic and Translational Obesity Research, Boston Children's Hospital, Boston, Massachusetts, USA. [2] Broad Institute of MIT and Harvard University, Cambridge, Massachusetts, USA. [3] Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA. [4] Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, Lyngby, Denmark.
Stefan Gustafsson1] Science for Life Laboratory, Uppsala University, Uppsala, Sweden. [2] Department of Medical Sciences, Molecular Epidemiology, Uppsala University, Uppsala, Sweden.
Audrey Y ChuDivision of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Karol Estrada1] Broad Institute of MIT and Harvard University, Cambridge, Massachusetts, USA. [2] Department of Internal Medicine, Erasmus Medical Center, Rotterdam, the Netherlands. [3] Analytic and Translational Genetics Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Jian'an LuanMedical Research Council (MRC) Epidemiology Unit, University of Cambridge, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK.
Zoltán Kutalik1] Institute of Social and Preventive Medicine (IUMSP), Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland. [2] Swiss Institute of Bioinformatics, Lausanne, Switzerland. [3] Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland.
Najaf AminGenetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands.
Martin L BuchkovichDepartment of Genetics, University of North Carolina, Chapel Hill, North Carolina, USA.
Damien C Croteau-Chonka1] Department of Genetics, University of North Carolina, Chapel Hill, North Carolina, USA. [2] Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Felix R DayMedical Research Council (MRC) Epidemiology Unit, University of Cambridge, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK.
Yanan DuanDepartment of Genetics, Division of Statistical Genomics, Washington University School of Medicine, St. Louis, Missouri, USA.
Tove Fall1] Science for Life Laboratory, Uppsala University, Uppsala, Sweden. [2] Department of Medical Sciences, Molecular Epidemiology, Uppsala University, Uppsala, Sweden. [3] Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Rudolf FehrmannDepartment of Genetics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
Teresa FerreiraWellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.
Anne U JacksonCenter for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, USA.
Juha KarjalainenDepartment of Genetics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
Ken Sin LoMontreal Heart Institute, Montreal, Quebec, Canada.
Adam E LockeCenter for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, USA.
Reedik Mägi1] Estonian Genome Center, University of Tartu, Tartu, Estonia. [2] Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.
Evelin Mihailov1] Estonian Genome Center, University of Tartu, Tartu, Estonia. [2] Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia.
Eleonora PorcuIstituto di Ricerca Genetica e Biomedica (IRGB), Consiglio Nazionale delle Ricerche, Cagliari, Italy.
Joshua C Randall1] Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK. [2] Wellcome Trust Sanger Institute, Hinxton, UK.
André Scherag1] Institute for Medical Informatics, Biometry and Epidemiology (IMIBE), University Hospital Essen, Essen, Germany. [2] Clinical Epidemiology, Integrated Research and Treatment Center, Center for Sepsis Control and Care (CSCC), Jena University Hospital, Jena, Germany.
Anna A E VinkhuyzenQueensland Brain Institute, University of Queensland, Brisbane, Queensland, Australia.
Harm-Jan WestraDepartment of Genetics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
Thomas W WinklerDepartment of Genetic Epidemiology, Institute of Epidemiology and Preventive Medicine, University of Regensburg, Regensburg, Germany.
Tsegaselassie WorkalemahuDepartment of Nutrition, Harvard School of Public Health, Harvard University, Boston, Massachusetts, USA.
Jing Hua ZhaoMedical Research Council (MRC) Epidemiology Unit, University of Cambridge, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK.
Devin AbsherHudsonAlpha Institute for Biotechnology, Huntsville, Alabama, USA.
Eva AlbrechtInstitute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
Denise AndersonTelethon Institute for Child Health Research, Centre for Child Health Research, University of Western Australia, Perth, Western Australia, Australia.
Jeffrey BaronSection on Growth and Development, Program in Developmental Endocrinology and Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, US National Institutes of Health, Bethesda, Maryland, USA.
Marian Beekman1] Netherlands Consortium for Healthy Aging (NCHA), Leiden University Medical Center, Leiden, the Netherlands. [2] Department of Molecular Epidemiology, Leiden University Medical Center, Leiden, the Netherlands.
Ayse Demirkan1] Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands. [2] Department of Human Genetics, Leiden University Medical Center, Leiden, the Netherlands.
Georg B Ehret1] Center for Complex Disease Genomics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. [2] Department of Specialties of Internal Medicine, Division of Cardiology, Geneva University Hospital, Geneva, Switzerland.
Bjarke FeenstraDepartment of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.
Mary F FeitosaDepartment of Genetics, Washington University School of Medicine, St. Louis, Missouri, USA.
Krista FischerEstonian Genome Center, University of Tartu, Tartu, Estonia.
Ross M FraserCentre for Population Health Sciences, University of Edinburgh, Edinburgh, UK.
Anuj Goel1] Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK. [2] Radcliffe Department of Medicine, Division of Cardiovascular Medicine, University of Oxford, Oxford, UK.
Jian GongDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
Anne E JusticeDepartment of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Stavroula KanoniWilliam Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Marcus E Kleber1] Vth Department of Medicine (Nephrology, Hypertensiology, Endocrinology, Diabetology, Rheumatology), Medical Faculty of Mannheim, University of Heidelberg, Heidelberg, Germany. [2] Department of Internal Medicine II, Ulm University Medical Centre, Ulm, Germany.
Kati KristianssonNational Institute for Health and Welfare, Helsinki, Finland.
Unhee LimEpidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii, USA.
Vaneet LotayCharles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Julian C LuiSection on Growth and Development, Program in Developmental Endocrinology and Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, US National Institutes of Health, Bethesda, Maryland, USA.
Massimo ManginoDepartment of Twin Research and Genetic Epidemiology, King's College London, London, UK.
Irene Mateo LeachDepartment of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
Carolina Medina-Gomez1] Department of Internal Medicine, Erasmus Medical Center, Rotterdam, the Netherlands. [2] Netherlands Consortium for Healthy Aging (NCHA), Rotterdam, the Netherlands. [3] Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.
Michael A NallsLaboratory of Neurogenetics, National Institute on Aging, US National Institutes of Health, Bethesda, Maryland, USA.
Dale R NyholtQIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Cameron D Palmer1] Division of Endocrinology, Genetics and Basic and Translational Obesity Research, Boston Children's Hospital, Boston, Massachusetts, USA. [2] Broad Institute of MIT and Harvard University, Cambridge, Massachusetts, USA.
Dorota PaskoGenetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, UK.
Sonali PechlivanisInstitute for Medical Informatics, Biometry and Epidemiology (IMIBE), University Hospital Essen, Essen, Germany.
Inga Prokopenko1] Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK. [2] Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK. [3] Department of Genomics of Common Disease, School of Public Health, Imperial College London, Hammersmith Hospital, London, UK.
Janina S RiedInstitute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
Stephan Ripke1] Analytic and Translational Genetics Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA. [2] Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard University, Cambridge, Massachusetts, USA.
Dmitry Shungin1] Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University Diabetes Center, Skåne University Hospital, Malmö, Sweden. [2] Department of Public Health and Clinical Medicine, Unit of Medicine, Umeå University, Umeå, Sweden. [3] Department of Odontology, Umeå University, Umeå, Sweden.
Alena StancákováDepartment of Medicine, University of Eastern Finland, Kuopio, Finland.
Rona J StrawbridgeAtherosclerosis Research Unit, Center for Molecular Medicine, Department of Medicine, Karolinska Institutet, Stockholm, Sweden.
Yun Ju SungDivision of Biostatistics, Washington University School of Medicine, St. Louis, Missouri, USA.
Toshiko TanakaTranslational Gerontology Branch, National Institute on Aging, Baltimore, Maryland, USA.
Alexander TeumerInterfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany.
Stella Trompet1] Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands. [2] Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, the Netherlands.
Sander W van der LaanExperimental Cardiology Laboratory, Division of Heart and Lungs, University Medical Center Utrecht, Utrecht, the Netherlands.
Jessica van SettenDepartment of Medical Genetics, University Medical Center Utrecht, Utrecht, the Netherlands.
Jana V Van Vliet-OstaptchoukDepartment of Endocrinology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Zhaoming Wang1] DZHK (Deutsches Zentrum für Herz-Kreislaufforschung-German Centre for Cardiovascular Research), partner site Greifswald, Greifswald, Germany. [2] Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany. [3] Division of Cancer Epidemiology and Genetics, National Cancer Institute, US National Institutes of Health, Bethesda, Maryland, USA. [4] Core Genotyping Facility, SAIC-Frederick, Inc., NCI-Frederick, Frederick, Maryland, USA.
Loïc Yengo1] CNRS UMR 8199, Lille, France. [2] European Genomic Institute for Diabetes, Lille, France. [3] Université de Lille 2, Lille, France.
Weihua Zhang1] Ealing Hospital National Health Service (NHS) Trust, Middlesex, UK. [2] Department of Epidemiology and Biostatistics, Imperial College London, London, UK.
Uzma Afzal1] Ealing Hospital National Health Service (NHS) Trust, Middlesex, UK. [2] Department of Epidemiology and Biostatistics, Imperial College London, London, UK.
Johan Arnlöv1] Science for Life Laboratory, Uppsala University, Uppsala, Sweden. [2] Department of Medical Sciences, Molecular Epidemiology, Uppsala University, Uppsala, Sweden. [3] School of Health and Social Studies, Dalarna University, Falun, Sweden.
Gillian M ArscottPathWest Laboratory Medicine of Western Australia, Nedlands, Western Australia, Australia.
Stefania BandinelliGeriatric Unit, Azienda Sanitaria Firenze (ASF), Florence, Italy.
Amy BarrettOxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK.
Claire BellisDepartment of Genetics, Texas Biomedical Research Institute, San Antonio, Texas, USA.
Amanda J BennettOxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK.
Christian BerneDepartment of Medical Sciences, Endocrinology, Diabetes and Metabolism, Uppsala University, Uppsala, Sweden.
Matthias Blüher1] Integrated Research and Treatment Center (IFB) Adiposity Diseases, University of Leipzig, Leipzig, Germany. [2] Department of Medicine, University of Leipzig, Leipzig, Germany.
Jennifer L BoltonCentre for Population Health Sciences, University of Edinburgh, Edinburgh, UK.
Yvonne BöttcherIntegrated Research and Treatment Center (IFB) Adiposity Diseases, University of Leipzig, Leipzig, Germany.
Heather A BoydDepartment of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.
Marcel BruinenbergLifeLines, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
Brendan M BuckleyDepartment of Pharmacology and Therapeutics, University College Cork, Cork, Ireland.
Steven Buyske1] Department of Statistics and Biostatistics, Rutgers University, Piscataway, New Jersy, USA. [2] Department of Genetics, Rutgers University, Piscataway, New Jersey, USA.
Ida H CaspersenDepartment of Biology, Norwegian University of Science and Technology, Trondheim, Norway.
Peter S ChinesGenome Technology Branch, National Human Genome Research Institute, US National Institutes of Health, Bethesda, Maryland, USA.
Robert ClarkeClinical Trial Service Unit, Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.
Simone Claudi-BoehmDivision of Endocrinology, Diabetes and Metabolism, Ulm University Medical Centre, Ulm, Germany.
Matthew CooperTelethon Institute for Child Health Research, Centre for Child Health Research, University of Western Australia, Perth, Western Australia, Australia.
E Warwick DawDepartment of Genetics, Washington University School of Medicine, St. Louis, Missouri, USA.
Pim A De JongDepartment of Radiology, University Medical Center Utrecht, Utrecht, the Netherlands.
Joris Deelen1] Netherlands Consortium for Healthy Aging (NCHA), Leiden University Medical Center, Leiden, the Netherlands. [2] Department of Molecular Epidemiology, Leiden University Medical Center, Leiden, the Netherlands.
Graciela DelgadoVth Department of Medicine (Nephrology, Hypertensiology, Endocrinology, Diabetology, Rheumatology), Medical Faculty of Mannheim, University of Heidelberg, Heidelberg, Germany.
Josh C DennyDepartment of Biomedical Informatics, Vanderbilt University, Nashville, Tennessee, USA.
Rosalie Dhonukshe-RuttenDepartment of Human Nutrition, Wageningen University, Wageningen, the Netherlands.
Maria DimitriouDepartment of Dietetics-Nutrition, Harokopio University, Athens, Greece.
Alex S F DoneyMedical Research Institute, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK.
Marcus Dörr1] DZHK (Deutsches Zentrum für Herz-Kreislaufforschung-German Centre for Cardiovascular Research), partner site Greifswald, Greifswald, Germany. [2] Department of Internal Medicine B, University Medicine Greifswald, Greifswald, Germany.
Niina Eklund1] National Institute for Health and Welfare, Helsinki, Finland. [2] Institute for Molecular Medicine, University of Helsinki, Helsinki, Finland.
Elodie Eury1] CNRS UMR 8199, Lille, France. [2] European Genomic Institute for Diabetes, Lille, France. [3] Université de Lille 2, Lille, France.
Lasse FolkersenAtherosclerosis Research Unit, Center for Molecular Medicine, Department of Medicine, Karolinska Institutet, Stockholm, Sweden.
Melissa E GarciaLaboratory of Epidemiology and Population Sciences, National Institute on Aging, US National Institutes of Health, Bethesda, Maryland, USA.
Frank GellerDepartment of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.
Vilmantas GiedraitisDepartment of Public Health and Caring Sciences, Geriatrics, Uppsala University, Uppsala, Sweden.
Alan S GoKaiser Permanente, Division of Research, Oakland, California, USA.
Harald Grallert1] Institute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany. [2] Research Unit of Molecular Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany. [3] German Center for Diabetes Research (DZD), Neuherberg, Germany.
Tanja B GrammerVth Department of Medicine (Nephrology, Hypertensiology, Endocrinology, Diabetology, Rheumatology), Medical Faculty of Mannheim, University of Heidelberg, Heidelberg, Germany.
Jürgen GräßlerDepartment of Medicine III, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
Henrik GrönbergDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Lisette C P G M de GrootDepartment of Human Nutrition, Wageningen University, Wageningen, the Netherlands.
Christopher J GrovesOxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK.
Jeffrey HaesslerDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
Per HallDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Toomas HallerEstonian Genome Center, University of Tartu, Tartu, Estonia.
Goran HallmansUnit of Nutritional Research, Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden.
Anke HannemannInstitute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany.
Catharina A HartmanDepartment of Psychiatry, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Maija HassinenKuopio Research Institute of Exercise Medicine, Kuopio, Finland.
Caroline HaywardMRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, UK.
Nancy L Heard-Costa1] National Heart, Lung, and Blood Institute, Framingham Heart Study, Framingham, Massachusetts, USA. [2] Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, USA.
Quinta Helmer1] Netherlands Consortium for Healthy Aging (NCHA), Leiden University Medical Center, Leiden, the Netherlands. [2] Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, Leiden, the Netherlands. [3] Faculty of Psychology and Education, VU University Amsterdam, Amsterdam, the Netherlands.
Gibran Hemani1] Queensland Brain Institute, University of Queensland, Brisbane, Queensland, Australia. [2] University of Queensland Diamantina Institute, Translation Research Institute, Brisbane, Queensland, Australia.
Anjali K HendersQIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Hans L Hillege1] Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands. [2] Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
Mark A HlatkyDepartment of Medicine, Stanford University School of Medicine, Stanford, California, USA.
Wolfgang Hoffmann1] DZHK (Deutsches Zentrum für Herz-Kreislaufforschung-German Centre for Cardiovascular Research), partner site Greifswald, Greifswald, Germany. [2] Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.
Per Hoffmann1] Department of Biomedicine, Division of Medical Genetics, University of Basel, Basel, Switzerland. [2] Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany. [3] Institute of Human Genetics, University of Bonn, Bonn, Germany.
Oddgeir HolmenDepartment of Public Health and General Practice, Norwegian University of Science and Technology, Trondheim, Norway.
Jeanine J Houwing-Duistermaat1] Netherlands Consortium for Healthy Aging (NCHA), Leiden University Medical Center, Leiden, the Netherlands. [2] Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, Leiden, the Netherlands.
Thomas Illig1] Research Unit of Molecular Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany. [2] Hannover Unified Biobank, Hannover Medical School, Hannover, Germany.
Aaron Isaacs1] Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands. [2] Center for Medical Systems Biology, Leiden, the Netherlands.
Alan L James1] Department of Pulmonary Physiology and Sleep Medicine, Nedlands, Western Australia, Australia. [2] School of Medicine and Pharmacology, University of Western Australia, Crawley, Western Australia, Australia.
Janina JeffCharles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Berit JohansenDepartment of Biology, Norwegian University of Science and Technology, Trondheim, Norway.
Åsa JohanssonDepartment of Immunology, Genetics and Pathology, SciLifeLab, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden.
Jennifer Jolley1] Department of Haematology, University of Cambridge, Cambridge, UK. [2] NHS Blood and Transplant, Cambridge, UK.
Thorhildur JuliusdottirWellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.
Juhani JunttilaDepartment of Medicine, University of Oulu, Oulu, Finland.
Abel N KhoDepartment of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Leena KinnunenNational Institute for Health and Welfare, Helsinki, Finland.
Norman Klopp1] Research Unit of Molecular Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany. [2] Hannover Unified Biobank, Hannover Medical School, Hannover, Germany.
Thomas KocherUnit of Periodontology, Department of Restorative Dentistry, Periodontology and Endodontology, University Medicine Greifswald, Greifswald, Germany.
Wolfgang KratzerDepartment of Internal Medicine I, Ulm University Medical Centre, Ulm, Germany.
Peter LichtnerInstitute of Human Genetics, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
Lars LindDepartment of Medical Sciences, Cardiovascular Epidemiology, Uppsala University, Uppsala, Sweden.
Jaana LindströmNational Institute for Health and Welfare, Helsinki, Finland.
Stéphane Lobbens1] CNRS UMR 8199, Lille, France. [2] European Genomic Institute for Diabetes, Lille, France. [3] Université de Lille 2, Lille, France.
Mattias LorentzonCentre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Yingchang Lu1] Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA. [2] Genetics of Obesity and Related Metabolic Traits Program, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Valeriya LyssenkoSteno Diabetes Center A/S, Gentofte Denmark.
Patrik K E MagnussonDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Anubha MahajanWellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.
Marc MaillardService of Nephrology, Department of Medicine, Lausanne University Hospital (CHUV), Lausanne, Switzerland.
Wendy L McArdleSchool of Social and Community Medicine, University of Bristol, Bristol, UK.
Colin A McKenzieTropical Metabolism Research Unit, Tropical Medicine Research Institute, University of the West Indies, Mona, Kingston, Jamaica.
Stela McLachlanCentre for Population Health Sciences, University of Edinburgh, Edinburgh, UK.
Paul J McLaren1] Global Health Institute, Department of Life Sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. [2] Institute of Microbiology, University Hospital and University of Lausanne, Lausanne, Switzerland.
Cristina MenniDepartment of Twin Research and Genetic Epidemiology, King's College London, London, UK.
Sigrun MergerDivision of Endocrinology, Diabetes and Metabolism, Ulm University Medical Centre, Ulm, Germany.
Lili MilaniEstonian Genome Center, University of Tartu, Tartu, Estonia.
Alireza MoayyeriDepartment of Twin Research and Genetic Epidemiology, King's College London, London, UK.
Keri L Monda1] Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. [2] Center for Observational Research, Amgen, Inc., Thousand Oaks, California, USA.
Mario A MorkenGenome Technology Branch, National Human Genome Research Institute, US National Institutes of Health, Bethesda, Maryland, USA.
Gabriele MüllerCenter for Evidence-Based Healthcare, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
Martina Müller-Nurasyid1] Institute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany. [2] Department of Medicine I, University Hospital Großhadern, Ludwig Maximilians Universität, Munich, Germany. [3] Chair of Genetic Epidemiology, Institute of Medical Informatics, Biometry and Epidemiology, Ludwig Maximilians Universität, Neuherberg, Germany. [4] DZHK (Deutsches Forschungszentrum für Herz-Kreislauferkrankungen-German Research Centre for Cardiovascular Research), Munich Heart Alliance, Munich, Germany.
Arthur W MuskDepartment of Respiratory Medicine, Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia.
Narisu NarisuGenome Technology Branch, National Human Genome Research Institute, US National Institutes of Health, Bethesda, Maryland, USA.
Matthias Nauck1] DZHK (Deutsches Zentrum für Herz-Kreislaufforschung-German Centre for Cardiovascular Research), partner site Greifswald, Greifswald, Germany. [2] Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany.
Ilja M NolteDepartment of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
Markus M Nöthen1] Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany. [2] Institute of Human Genetics, University of Bonn, Bonn, Germany.
Laticia OozageerEaling Hospital National Health Service (NHS) Trust, Middlesex, UK.
Stefan Pilz1] Department of Epidemiology and Biostatistics, Institute for Research in Extramural Medicine (EMGO) Institute for Health and Care Research, VU University Medical Center, Amsterdam, the Netherlands. [2] Department of Internal Medicine, Division of Endocrinology and Metabolism, Medical University of Graz, Graz, Austria.
Nigel W Rayner1] Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK. [2] Wellcome Trust Sanger Institute, Hinxton, UK. [3] Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK.
Frida RenstromDepartment of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University Diabetes Center, Skåne University Hospital, Malmö, Sweden.
Neil R Robertson1] Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK. [2] Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK.
Lynda M RoseDivision of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Ronan Roussel1] Diabetology-Endocrinology-Nutrition, Public Hospital System of the City of Paris (AP-HP), Bichat Hospital, Paris, France. [2] INSERM U872, Centre de Recherche des Cordeliers, Paris, France. [3] Paris Diderot University, Paris, France.
Serena SannaIstituto di Ricerca Genetica e Biomedica (IRGB), Consiglio Nazionale delle Ricerche, Cagliari, Italy.
Hubert ScharnaglClinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria.
Salome ScholtensDepartment of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
Fredrick R SchumacherDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Heribert Schunkert1] DZHK (Deutsches Forschungszentrum für Herz-Kreislauferkrankungen-German Research Centre for Cardiovascular Research), Munich Heart Alliance, Munich, Germany. [2] Deutsches Herzzentrum München, Technische Universität München, Munich, Germany.
Robert A ScottMedical Research Council (MRC) Epidemiology Unit, University of Cambridge, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK.
Joban Sehmi1] Ealing Hospital National Health Service (NHS) Trust, Middlesex, UK. [2] Department of Epidemiology and Biostatistics, Imperial College London, London, UK.
Thomas SeufferleinDepartment of Internal Medicine I, Ulm University Medical Centre, Ulm, Germany.
Jianxin ShiNational Cancer Institute, Bethesda, Maryland, USA.
Karri SilventoinenDepartment of Sociology, University of Helsinki, Helsinki, Finland.
Johannes H Smit1] EMGO Institute for Health and Care Research, VU University, Amsterdam, the Netherlands. [2] Department of Psychiatry, Neuroscience Campus, VU University Amsterdam, Amsterdam, the Netherlands.
Albert Vernon Smith1] Icelandic Heart Association, Kopavogur, Iceland. [2] University of Iceland, Reykjavik, Iceland.
Joanna Smolonska1] Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands. [2] Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
Alice V StantonMolecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland.
Kathleen Stirrups1] Wellcome Trust Sanger Institute, Hinxton, UK. [2] William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
David J StottInstitute of Cardiovascular and Medical Sciences, Faculty of Medicine, University of Glasgow, Glasgow, UK.
Heather M StringhamCenter for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, USA.
Johan SundströmDepartment of Medical Sciences, Cardiovascular Epidemiology, Uppsala University, Uppsala, Sweden.
Morris A SwertzDepartment of Genetics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
Ann-Christine Syvänen1] Science for Life Laboratory, Uppsala University, Uppsala, Sweden. [2] Department of Medical Sciences, Molecular Medicine, Uppsala University, Uppsala, Sweden.
Bamidele O TayoDepartment of Public Health Sciences, Stritch School of Medicine, Loyola University of Chicago, Maywood, Illinois, USA.
Gudmar ThorleifssondeCODE Genetics, Amgen, Inc., Reykjavik, Iceland.
Jonathan P TyrerDepartment of Oncology, University of Cambridge, Cambridge, UK.
Suzanne van DijkDepartment of Internal Medicine, Erasmus Medical Center, Rotterdam, the Netherlands.
Natasja M van SchoorDepartment of Epidemiology and Biostatistics, Institute for Research in Extramural Medicine (EMGO) Institute for Health and Care Research, VU University Medical Center, Amsterdam, the Netherlands.
Nathalie van der Velde1] Department of Internal Medicine, Erasmus Medical Center, Rotterdam, the Netherlands. [2] Section of Geriatrics, Department of Internal Medicine, Academic Medical Center, Amsterdam, the Netherlands.
Diana van Heemst1] Netherlands Consortium for Healthy Aging (NCHA), Leiden University Medical Center, Leiden, the Netherlands. [2] Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, the Netherlands.
Floor V A van OortDepartment of Child and Adolescent Psychiatry, Psychology, Erasmus University Medical Center, Rotterdam, the Netherlands.
Sita H Vermeulen1] Department for Health Evidence, Radboud University Medical Centre, Nijmegen, the Netherlands. [2] Department of Genetics, Radboud University Medical Centre, Nijmegen, the Netherlands.
Niek VerweijDepartment of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
Judith M VonkDepartment of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
Lindsay L WaiteHudsonAlpha Institute for Biotechnology, Huntsville, Alabama, USA.
Melanie WaldenbergerResearch Unit of Molecular Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
Roman WennauerDepartment of Clinical Chemistry, Ulm University Medical Centre, Ulm, Germany.
Lynne R WilkensEpidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii, USA.
Christina Willenborg1] DZHK (Deutsches Forschungszentrum für Herz-Kreislauferkrankungen-German Research Centre for Cardiovascular Research), partner site Hamburg-Lubeck-Kiel, Lubeck, Germany. [2] Institut für Integrative und Experimentelle Genomik, Universität zu Lübeck, Lübeck, Germany.
Tom WilsgaardDepartment of Community Medicine, Faculty of Health Sciences, UiT The Arctic University of Tromsø, Tromsø, Norway.
Mary K WojczynskiDepartment of Genetics, Washington University School of Medicine, St. Louis, Missouri, USA.
Andrew WongMRC Unit for Lifelong Health and Ageing at University College London, London, UK.
Alan F WrightMRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, UK.
Qunyuan ZhangDepartment of Genetics, Washington University School of Medicine, St. Louis, Missouri, USA.
Dominique ArveilerDepartment of Epidemiology and Public Health, University of Strasbourg, Faculty of Medicine, Strasbourg, France.
Stephan J L BakkerDepartment of Internal Medicine, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
John Beilby1] PathWest Laboratory Medicine of Western Australia, Nedlands, Western Australia, Australia. [2] Pathology and Laboratory Medicine, University of Western Australia, Perth, Western Australia, Australia.
Richard N BergmanCedars-Sinai Diabetes and Obesity Research Institute, Los Angeles, California, USA.
Sven Bergmann1] Swiss Institute of Bioinformatics, Lausanne, Switzerland. [2] Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland.
Reiner BiffarDepartment of Prosthetic Dentistry, Gerostomatology and Dental Materials, University Medicine Greifswald, Greifswald, Germany.
John BlangeroDepartment of Genetics, Texas Biomedical Research Institute, San Antonio, Texas, USA.
Dorret I BoomsmaBiological Psychology, VU University Amsterdam, Amsterdam, the Netherlands.
Stefan R BornsteinDepartment of Medicine III, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
Pascal Bovet1] Institute of Social and Preventive Medicine (IUMSP), Centre Hospitalier Universitaire Vaudois (CHUV) and University of Lausanne, Lausanne, Switzerland. [2] Ministry of Health, Victoria, Republic of Seychelles.
Paolo BrambillaLaboratory Medicine, Hospital of Desio, Department of Health Sciences, University of Milano, Bicocca, Italy.
Morris J BrownClinical Pharmacology Unit, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK.
Harry CampbellCentre for Population Health Sciences, University of Edinburgh, Edinburgh, UK.
Mark J Caulfield1] Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK. [2] Barts and The London Genome Centre, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Aravinda ChakravartiCenter for Complex Disease Genomics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Rory CollinsClinical Trial Service Unit, Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.
Francis S CollinsGenome Technology Branch, National Human Genome Research Institute, US National Institutes of Health, Bethesda, Maryland, USA.
Dana C Crawford1] Center for Human Genetics Research, Vanderbilt University Medical Center, Nashville, Tennessee, USA. [2] Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee, USA.
L Adrienne Cupples1] National Heart, Lung, and Blood Institute, Framingham Heart Study, Framingham, Massachusetts, USA. [2] Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA.
John DaneshDepartment of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Ulf de FaireDivision of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Hester M den Ruijter1] Experimental Cardiology Laboratory, Division of Heart and Lungs, University Medical Center Utrecht, Utrecht, the Netherlands. [2] Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands.
Raimund ErbelClinic of Cardiology, West German Heart Centre, University Hospital Essen, Essen, Germany.
Jeanette Erdmann1] DZHK (Deutsches Forschungszentrum für Herz-Kreislauferkrankungen-German Research Centre for Cardiovascular Research), partner site Hamburg-Lubeck-Kiel, Lubeck, Germany. [2] Institut für Integrative und Experimentelle Genomik, Universität zu Lübeck, Lübeck, Germany.
Johan G Eriksson1] National Institute for Health and Welfare, Helsinki, Finland. [2] Department of General Practice and Primary Health Care, University of Helsinki, Helsinki, Finland. [3] Unit of General Practice, Helsinki University Central Hospital, Helsinki, Finland.
Martin Farrall1] Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK. [2] Radcliffe Department of Medicine, Division of Cardiovascular Medicine, University of Oxford, Oxford, UK.
Ele Ferrannini1] Department of Internal Medicine, University of Pisa, Pisa, Italy. [2] National Research Council (CNR) Institute of Clinical Physiology, University of Pisa, Pisa, Italy.
Jean FerrièresDepartment of Cardiology, Toulouse University School of Medicine, Rangueil Hospital, Toulouse, France.
Ian FordRobertson Center for Biostatistics, University of Glasgow, Glasgow, UK.
Nita G ForouhiMedical Research Council (MRC) Epidemiology Unit, University of Cambridge, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK.
Terrence ForresterTropical Metabolism Research Unit, Tropical Medicine Research Institute, University of the West Indies, Mona, Kingston, Jamaica.
Ron T GansevoortDepartment of Internal Medicine, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
Pablo V GejmanNorthShore University HealthSystem, University of Chicago, Evanston, Illinois, USA.
Christian GiegerInstitute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
Alain GolayService of Therapeutic Education for Diabetes, Obesity and Chronic Diseases, Geneva University Hospital, Geneva, Switzerland.
Omri GottesmanCharles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Vilmundur Gudnason1] Icelandic Heart Association, Kopavogur, Iceland. [2] University of Iceland, Reykjavik, Iceland.
Ulf GyllenstenDepartment of Immunology, Genetics and Pathology, SciLifeLab, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden.
David W HaasDepartment of Medicine, Pharmacology, Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Alistair S HallLeeds MRC Medical Bioinformatics Centre, University of Leeds, Leeds, UK.
Tamara B HarrisLaboratory of Epidemiology and Population Sciences, National Institute on Aging, US National Institutes of Health, Bethesda, Maryland, USA.
Andrew T HattersleyInstitute of Biomedical and Clinical Science, University of Exeter, Exeter, UK.
Andrew C HeathDepartment of Psychiatry, Washington University School of Medicine, St. Louis, Missouri, USA.
Christian Hengstenberg1] DZHK (Deutsches Forschungszentrum für Herz-Kreislauferkrankungen-German Research Centre for Cardiovascular Research), Munich Heart Alliance, Munich, Germany. [2] Deutsches Herzzentrum München, Technische Universität München, Munich, Germany.
Andrew A HicksCenter for Biomedicine, European Academy Bozen, Bolzano (EURAC), Bolzano, Italy (affiliated institute of the University of Lübeck, Lübeck, Germany).
Lucia A HindorffDivision of Genomic Medicine, National Human Genome Research Institute, US National Institutes of Health, Bethesda, Maryland, USA.
Aroon D HingoraniInstitute of Cardiovascular Science, University College London, London, UK.
Albert Hofman1] Netherlands Consortium for Healthy Aging (NCHA), Rotterdam, the Netherlands. [2] Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.
G Kees HovinghDepartment of Vascular Medicine, Academic Medical Center, Amsterdam, the Netherlands.
Steve E HumphriesCentre for Cardiovascular Genetics, Institute of Cardiovascular Sciences, University College London, London, UK.
Steven C HuntCardiovascular Genetics Division, Department of Internal Medicine, University of Utah, Salt Lake City, Utah, USA.
Elina Hypponen1] School of Population Health, University of South Australia, Adelaide, South Australia, Australia. [2] Sansom Institute for Health Research, University of South Australia, Adelaide, South Australia, Australia. [3] South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia. [4] Centre for Paediatric Epidemiology and Biostatistics, University College London Institute of Child Health, London, UK.
Kevin B Jacobs1] Division of Cancer Epidemiology and Genetics, National Cancer Institute, US National Institutes of Health, Bethesda, Maryland, USA. [2] Core Genotyping Facility, SAIC-Frederick, Inc., NCI-Frederick, Frederick, Maryland, USA.
Marjo-Riitta Jarvelin1] Department of Epidemiology and Biostatistics, Imperial College London, London, UK. [2] National Institute for Health and Welfare, Oulu, Finland. [3] MRC Health Protection Agency (HPA) Centre for Environment and Health, School of Public Health, Imperial College London, London, UK. [4] Unit of Primary Care, Oulu University Hospital, Oulu, Finland. [5] Biocenter Oulu, University of Oulu, Oulu, Finland. [6] Institute of Health Sciences, University of Oulu, Oulu, Finland.
Pekka JousilahtiNational Institute for Health and Welfare, Helsinki, Finland.
Antti M JulaNational Institute for Health and Welfare, Helsinki, Finland.
Jaakko Kaprio1] National Institute for Health and Welfare, Helsinki, Finland. [2] Institute for Molecular Medicine, University of Helsinki, Helsinki, Finland. [3] Hjelt Institute Department of Public Health, University of Helsinki, Helsinki, Finland.
John J P KasteleinDepartment of Vascular Medicine, Academic Medical Center, Amsterdam, the Netherlands.
Manfred Kayser1] Netherlands Consortium for Healthy Aging (NCHA), Rotterdam, the Netherlands. [2] Department of Forensic Molecular Biology, Erasmus Medical Center, Rotterdam, the Netherlands.
Frank KeeUK Clinical Research Collaboration Centre of Excellence for Public Health (Northern Ireland), Queens University of Belfast, Belfast, UK.
Sirkka M Keinanen-Kiukaanniemi1] Faculty of Medicine, Institute of Health Sciences, University of Oulu, Oulu, Finland. [2] Unit of General Practice, Oulu University Hospital, Oulu, Finland.
Lambertus A Kiemeney1] Department for Health Evidence, Radboud University Medical Centre, Nijmegen, the Netherlands. [2] Department of Urology, Radboud University Medical Centre, Nijmegen, the Netherlands.
Jaspal S Kooner1] Ealing Hospital National Health Service (NHS) Trust, Middlesex, UK. [2] Imperial College Healthcare NHS Trust, London, UK. [3] National Heart and Lung Institute, Imperial College London, London, UK.
Charles KooperbergDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
Seppo KoskinenNational Institute for Health and Welfare, Helsinki, Finland.
Peter Kovacs1] Integrated Research and Treatment Center (IFB) Adiposity Diseases, University of Leipzig, Leipzig, Germany. [2] Department of Medicine, University of Leipzig, Leipzig, Germany.
Aldi T KrajaDepartment of Genetics, Washington University School of Medicine, St. Louis, Missouri, USA.
Meena KumariDepartment of Epidemiology and Public Health, University College London, London, UK.
Johanna KuusistoDepartment of Medicine, Kuopio University Hospital and University of Eastern Finland, Kuopio, Finland.
Timo A Lakka1] Kuopio Research Institute of Exercise Medicine, Kuopio, Finland. [2] Department of Physiology, Institute of Biomedicine, University of Eastern Finland, Kuopio Campus, Kuopio, Finland. [3] Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital and University of Eastern Finland, Kuopio, Finland.
Claudia Langenberg1] Medical Research Council (MRC) Epidemiology Unit, University of Cambridge, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK. [2] Department of Epidemiology and Public Health, University College London, London, UK.
Loic Le MarchandEpidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii, USA.
Terho LehtimäkiDepartment of Clinical Chemistry, Fimlab Laboratories and School of Medicine, University of Tampere, Tampere, Finland.
Sara Lupoli1] Department of Health Sciences, University of Milano, Milan, Italy. [2] Fondazione Filarete, Milan, Italy.
Pamela A F MaddenDepartment of Psychiatry, Washington University School of Medicine, St. Louis, Missouri, USA.
Satu MännistöNational Institute for Health and Welfare, Helsinki, Finland.
Paolo Manunta1] Division of Nephrology and Dialysis, San Raffaele Scientific Institute, Milan, Italy. [2] Università Vita-Salute San Raffaele, Milan, Italy.
André Marette1] Institut Universitaire de Cardiologie et de Pneumologie de Québec, Faculty of Medicine, Laval University, Quebec City, Quebec, Canada. [2] Institute of Nutrition and Functional Foods, Laval University, Quebec City, Quebec, Canada.
Tara C MatiseDepartment of Genetics, Rutgers University, Piscataway, New Jersey, USA.
Barbara McKnightDepartment of Biostatistics, University of Washington, Seattle, Washington, USA.
Thomas MeitingerDZHK (Deutsches Forschungszentrum für Herz-Kreislauferkrankungen-German Research Centre for Cardiovascular Research), Munich Heart Alliance, Munich, Germany.
Frans L MollDepartment of Surgery, University Medical Center Utrecht, Utrecht, the Netherlands.
Grant W MontgomeryQIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Andrew D MorrisMedical Research Institute, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK.
Andrew P Morris1] Estonian Genome Center, University of Tartu, Tartu, Estonia. [2] Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK. [3] Department of Biostatistics, University of Liverpool, Liverpool, UK.
Jeffrey C MurrayDepartment of Pediatrics, University of Iowa, Iowa City, Iowa, USA.
Mari NelisEstonian Genome Center, University of Tartu, Tartu, Estonia.
Claes OhlssonCentre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Albertine J OldehinkelDepartment of Psychiatry, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Ken K Ong1] Medical Research Council (MRC) Epidemiology Unit, University of Cambridge, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK. [2] MRC Unit for Lifelong Health and Ageing at University College London, London, UK.
Willem H Ouwehand1] Department of Haematology, University of Cambridge, Cambridge, UK. [2] NHS Blood and Transplant, Cambridge, UK.
Gerard PasterkampExperimental Cardiology Laboratory, Division of Heart and Lungs, University Medical Center Utrecht, Utrecht, the Netherlands.
Annette Peters1] Research Unit of Molecular Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany. [2] DZHK (Deutsches Forschungszentrum für Herz-Kreislauferkrankungen-German Research Centre for Cardiovascular Research), Munich Heart Alliance, Munich, Germany. [3] Institute of Epidemiology II, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
Peter P Pramstaller1] Center for Biomedicine, European Academy Bozen, Bolzano (EURAC), Bolzano, Italy (affiliated institute of the University of Lübeck, Lübeck, Germany). [2] Department of Neurology, General Central Hospital, Bolzano, Italy.
Jackie F PriceCentre for Population Health Sciences, University of Edinburgh, Edinburgh, UK.
Lu Qi1] Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA. [2] Department of Nutrition, Harvard School of Public Health, Harvard University, Boston, Massachusetts, USA.
Olli T Raitakari1] Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland. [2] Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.
Tuomo RankinenHuman Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA.
D C Rao1] Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, USA. [2] Division of Biostatistics, Washington University School of Medicine, St. Louis, Missouri, USA. [3] Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri, USA.
Treva K Rice1] Division of Biostatistics, Washington University School of Medicine, St. Louis, Missouri, USA. [2] Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri, USA.
Marylyn RitchieCenter for Systems Genomics, Pennsylvania State University, University Park, Pennsylvania, USA.
Igor Rudan1] Centre for Population Health Sciences, University of Edinburgh, Edinburgh, UK. [2] Croatian Centre for Global Health, Faculty of Medicine, University of Split, Split, Croatia.
Veikko SalomaaNational Institute for Health and Welfare, Helsinki, Finland.
Nilesh J Samani1] Department of Cardiovascular Sciences, University of Leicester, Glenfield Hospital, Leicester, UK. [2] National Institute for Health Research (NIHR) Leicester Cardiovascular Biomedical Research Unit, Glenfield Hospital, Leicester, UK.
Jouko SaramiesSouth Carelia Central Hospital, Lappeenranta, Finland.
Mark A SarzynskiHuman Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA.
Peter E H Schwarz1] Department of Medicine III, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany. [2] Paul Langerhans Institute Dresden, German Center for Diabetes Research (DZD), Dresden, Germany.
Sylvain SebertInstitute of Health Sciences, University of Oulu, Oulu, Finland.
Peter SeverInternational Centre for Circulatory Health, Imperial College London, London, UK.
Alan R Shuldiner1] Program for Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA. [2] Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, Maryland, USA. [3] Geriatric Research and Education Clinical Center, Vetrans Administration Medical Center, Baltimore, Maryland, USA.
Juha SinisaloHelsinki University Central Hospital Heart and Lung Center, Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland.
Valgerdur SteinthorsdottirdeCODE Genetics, Amgen, Inc., Reykjavik, Iceland.
Ronald P StolkDepartment of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
Jean-Claude Tardif1] Montreal Heart Institute, Montreal, Quebec, Canada. [2] Montreal Heart Institute, Université de Montréal, Montreal, Quebec, Canada.
Anke Tönjes1] Integrated Research and Treatment Center (IFB) Adiposity Diseases, University of Leipzig, Leipzig, Germany. [2] Department of Medicine, University of Leipzig, Leipzig, Germany.
Angelo TremblayDepartment of Kinesiology, Laval University, Quebec City, Quebec, Canada.
Elena TremoliDipartimento di Scienze Farmacologiche e Biomolecolari, Università di Milano and Centro Cardiologico Monzino, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Milan, Italy.
Jarmo VirtamoNational Institute for Health and Welfare, Helsinki, Finland.
Marie-Claude Vohl1] Institute of Nutrition and Functional Foods, Laval University, Quebec City, Quebec, Canada. [2] Department of Food Science and Nutrition, Laval University, Quebec City, Quebec, Canada.
Electronic Medical Records and Genomics (eMEMERGEGE) Consortium
MIGen Consortium
PAGEGE Consortium
LifeLines Cohort Study
Philippe AmouyelInstitut Pasteur de Lille, INSERM U744, Université de Lille 2, Lille, France.
Folkert W Asselbergs1] Institute of Cardiovascular Science, University College London, London, UK. [2] Department of Cardiology, Division of Heart and Lungs, University Medical Center Utrecht, Utrecht, the Netherlands. [3] Durrer Center for Cardiogenetic Research, Interuniversity Cardiology Institute Netherlands-Netherlands Heart Institute, Utrecht, the Netherlands.
Themistocles L AssimesDepartment of Medicine, Stanford University School of Medicine, Stanford, California, USA.
Murielle Bochud1] Institute of Social and Preventive Medicine (IUMSP), Centre Hospitalier Universitaire Vaudois (CHUV) and University of Lausanne, Lausanne, Switzerland. [2] Ministry of Health, Victoria, Republic of Seychelles.
Bernhard O Boehm1] Division of Endocrinology, Diabetes and Metabolism, Ulm University Medical Centre, Ulm, Germany. [2] Lee Kong Chian School of Medicine, Imperial College London and Nanyang Technological University, Singapore.
Eric BoerwinkleHealth Science Center at Houston, University of Texas, Houston, Texas, USA.
Erwin P BottingerCharles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Claude BouchardHuman Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA.
Stéphane Cauchi1] CNRS UMR 8199, Lille, France. [2] European Genomic Institute for Diabetes, Lille, France. [3] Université de Lille 2, Lille, France.
John C Chambers1] Ealing Hospital National Health Service (NHS) Trust, Middlesex, UK. [2] Department of Epidemiology and Biostatistics, Imperial College London, London, UK. [3] Imperial College Healthcare NHS Trust, London, UK.
Stephen J ChanockDivision of Cancer Epidemiology and Genetics, National Cancer Institute, US National Institutes of Health, Bethesda, Maryland, USA.
Richard S CooperDepartment of Public Health Sciences, Stritch School of Medicine, Loyola University of Chicago, Maywood, Illinois, USA.
Paul I W de Bakker1] Department of Medical Genetics, University Medical Center Utrecht, Utrecht, the Netherlands. [2] Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA. [3] Department of Epidemiology, University Medical Center Utrecht, Utrecht, the Netherlands.
George DedoussisDepartment of Dietetics-Nutrition, Harokopio University, Athens, Greece.
Luigi FerrucciTranslational Gerontology Branch, National Institute on Aging, Baltimore, Maryland, USA.
Paul W Franks1] Department of Nutrition, Harvard School of Public Health, Harvard University, Boston, Massachusetts, USA. [2] Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University Diabetes Center, Skåne University Hospital, Malmö, Sweden. [3] Department of Public Health and Clinical Medicine, Unit of Medicine, Umeå University, Umeå, Sweden.
Philippe Froguel1] Department of Genomics of Common Disease, School of Public Health, Imperial College London, Hammersmith Hospital, London, UK. [2] CNRS UMR 8199, Lille, France. [3] European Genomic Institute for Diabetes, Lille, France. [4] Université de Lille 2, Lille, France.
Leif C Groop1] Institute for Molecular Medicine, University of Helsinki, Helsinki, Finland. [2] Lund University Diabetes Centre, Lund University, Malmö, Sweden. [3] Diabetes and Endocrinology Unit, Department of Clinical Science, Lund University, Malmö, Sweden.
Christopher A HaimanDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Anders HamstenAtherosclerosis Research Unit, Center for Molecular Medicine, Department of Medicine, Karolinska Institutet, Stockholm, Sweden.
M Geoffrey HayesDepartment of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Jennie Hui1] PathWest Laboratory Medicine of Western Australia, Nedlands, Western Australia, Australia. [2] Pathology and Laboratory Medicine, University of Western Australia, Perth, Western Australia, Australia. [3] School of Population Health, University of South Australia, Adelaide, South Australia, Australia. [4] Sansom Institute for Health Research, University of South Australia, Adelaide, South Australia, Australia.
David J Hunter1] Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA. [2] Department of Nutrition, Harvard School of Public Health, Harvard University, Boston, Massachusetts, USA. [3] Department of Epidemiology, Harvard School of Public Health, Harvard University, Boston, Massachusetts, USA.
Kristian HveemDepartment of Public Health and General Practice, Norwegian University of Science and Technology, Trondheim, Norway.
J Wouter Jukema1] Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands. [2] Durrer Center for Cardiogenetic Research, Interuniversity Cardiology Institute Netherlands-Netherlands Heart Institute, Utrecht, the Netherlands. [3] Interuniversity Cardiology Institute of the Netherlands (ICIN), Utrecht, the Netherlands.
Robert C KaplanDepartment of Epidemiology and Population Health, Albert Einstein College of Medicine. Belfer, New York, USA.
Mika KivimakiDepartment of Epidemiology and Public Health, University College London, London, UK.
Diana KuhMRC Unit for Lifelong Health and Ageing at University College London, London, UK.
Markku LaaksoDepartment of Medicine, Kuopio University Hospital and University of Eastern Finland, Kuopio, Finland.
Yongmei LiuCenter for Human Genetics, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
Nicholas G MartinQIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Winfried März1] Vth Department of Medicine (Nephrology, Hypertensiology, Endocrinology, Diabetology, Rheumatology), Medical Faculty of Mannheim, University of Heidelberg, Heidelberg, Germany. [2] Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria. [3] Synlab Academy, Synlab Services, Mannheim, Germany.
Mads Melbye1] Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark. [2] Department of Medicine, Stanford University School of Medicine, Stanford, California, USA.
Susanne MoebusInstitute for Medical Informatics, Biometry and Epidemiology (IMIBE), University Hospital Essen, Essen, Germany.
Patricia B Munroe1] Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK. [2] Barts and The London Genome Centre, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Inger NjølstadDepartment of Community Medicine, Faculty of Health Sciences, UiT The Arctic University of Tromsø, Tromsø, Norway.
Ben A Oostra1] Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands. [2] Center for Medical Systems Biology, Leiden, the Netherlands. [3] Department of Clinical Genetics, Erasmus University Medical Center, Rotterdam, the Netherlands.
Colin N A PalmerMedical Research Institute, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK.
Nancy L PedersenDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Markus Perola1] Estonian Genome Center, University of Tartu, Tartu, Estonia. [2] National Institute for Health and Welfare, Helsinki, Finland. [3] Institute for Molecular Medicine, University of Helsinki, Helsinki, Finland.
Louis Pérusse1] Institute of Nutrition and Functional Foods, Laval University, Quebec City, Quebec, Canada. [2] Department of Kinesiology, Laval University, Quebec City, Quebec, Canada.
Ulrike PetersDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
Joseph E Powell1] Queensland Brain Institute, University of Queensland, Brisbane, Queensland, Australia. [2] University of Queensland Diamantina Institute, Translation Research Institute, Brisbane, Queensland, Australia.
Chris PowerCentre for Paediatric Epidemiology and Biostatistics, University College London Institute of Child Health, London, UK.
Thomas QuertermousDepartment of Medicine, Stanford University School of Medicine, Stanford, California, USA.
Rainer Rauramaa1] Kuopio Research Institute of Exercise Medicine, Kuopio, Finland. [2] Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital and University of Eastern Finland, Kuopio, Finland.
Eva ReinmaaEstonian Genome Center, University of Tartu, Tartu, Estonia.
Paul M Ridker1] Division of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA. [2] Harvard Medical School, Boston, Massachusetts, USA.
Fernando Rivadeneira1] Department of Internal Medicine, Erasmus Medical Center, Rotterdam, the Netherlands. [2] Netherlands Consortium for Healthy Aging (NCHA), Rotterdam, the Netherlands. [3] Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.
Jerome I RotterInstitute for Translational Genomics and Population Sciences, Los Angeles BioMedical Research Institute at Harbor-University of California, Los Angeles Medical Center, Torrance, California, USA.
Timo E Saaristo1] Finnish Diabetes Association, Tampere, Finland. [2] Pirkanmaa Hospital District, Tampere, Finland.
Danish Saleheen1] Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK. [2] Center for Non-Communicable Diseases, Karatchi, Pakistan. [3] Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
David SchlessingerLaboratory of Genetics, National Institute on Aging, Baltimore, Maryland, USA.
P Eline Slagboom1] Netherlands Consortium for Healthy Aging (NCHA), Leiden University Medical Center, Leiden, the Netherlands. [2] Department of Molecular Epidemiology, Leiden University Medical Center, Leiden, the Netherlands.
Harold SniederDepartment of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
Tim D SpectorDepartment of Twin Research and Genetic Epidemiology, King's College London, London, UK.
Konstantin Strauch1] Institute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany. [2] Chair of Genetic Epidemiology, Institute of Medical Informatics, Biometry and Epidemiology, Ludwig Maximilians Universität, Neuherberg, Germany.
Michael Stumvoll1] Integrated Research and Treatment Center (IFB) Adiposity Diseases, University of Leipzig, Leipzig, Germany. [2] Department of Medicine, University of Leipzig, Leipzig, Germany.
Jaakko Tuomilehto1] National Institute for Health and Welfare, Helsinki, Finland. [2] Instituto de Investigacion Sanitaria del Hospital Universario La Paz (IdiPAZ), Madrid, Spain. [3] Diabetes Research Group, King Abdulaziz University, Jeddah, Saudi Arabia. [4] Centre for Vascular Prevention, Danube University Krems, Krems, Austria.
Matti Uusitupa1] Department of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland. [2] Research Unit, Kuopio University Hospital, Kuopio, Finland.
Pim van der Harst1] Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands. [2] Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands. [3] Durrer Center for Cardiogenetic Research, Interuniversity Cardiology Institute Netherlands-Netherlands Heart Institute, Utrecht, the Netherlands.
Henry Völzke1] DZHK (Deutsches Zentrum für Herz-Kreislaufforschung-German Centre for Cardiovascular Research), partner site Greifswald, Greifswald, Germany. [2] Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.
Mark WalkerInstitute of Cellular Medicine, Newcastle University, Newcastle, UK.
Nicholas J WarehamMedical Research Council (MRC) Epidemiology Unit, University of Cambridge, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK.
Hugh Watkins1] Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK. [2] Radcliffe Department of Medicine, Division of Cardiovascular Medicine, University of Oxford, Oxford, UK.
H-Erich Wichmann1] Chair of Epidemiology, Institute of Medical Informatics, Biometry and Epidemiology, Ludwig Maximilians Universität, Munich, Germany. [2] Klinikum Großhadern, Munich, Germany. [3] Institute of Epidemiology I, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
James F WilsonCentre for Population Health Sciences, University of Edinburgh, Edinburgh, UK.
Pieter ZanenDepartment of Pulmonology, University Medical Center Utrecht, Utrecht, the Netherlands.
Panos Deloukas1] Wellcome Trust Sanger Institute, Hinxton, UK. [2] William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK. [3] King Abdulaziz University, Jeddah, Saudi Arabia.
Iris M Heid1] Department of Genetic Epidemiology, Institute of Epidemiology and Preventive Medicine, University of Regensburg, Regensburg, Germany. [2] Institute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
Cecilia M Lindgren1] Broad Institute of MIT and Harvard University, Cambridge, Massachusetts, USA. [2] Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.
Karen L MohlkeDepartment of Genetics, University of North Carolina, Chapel Hill, North Carolina, USA.
Elizabeth K Speliotes1] Department of Internal Medicine, Division of Gastroenterology, University of Michigan, Ann Arbor, Michigan, USA. [2] Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan, USA.
Unnur Thorsteinsdottir1] deCODE Genetics, Amgen, Inc., Reykjavik, Iceland. [2] Faculty of Medicine, University of Iceland, Reykjavik, Iceland.
Inês Barroso1] Wellcome Trust Sanger Institute, Hinxton, UK. [2] University of Cambridge Metabolic Research Laboratories, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK. [3] NIHR Cambridge Biomedical Research Centre, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK.
Caroline S FoxNational Heart, Lung, and Blood Institute, Framingham Heart Study, Framingham, Massachusetts, USA.
Kari E North1] Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. [2] Carolina Center for Genome Sciences, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
David P StrachanDivision of Population Health Sciences and Education, St George's, University of London, London, UK.
Jacques S Beckmann1] Swiss Institute of Bioinformatics, Lausanne, Switzerland. [2] Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland. [3] Service of Medical Genetics, CHUV University Hospital, Lausanne, Switzerland.
Sonja I BerndtDivision of Cancer Epidemiology and Genetics, National Cancer Institute, US National Institutes of Health, Bethesda, Maryland, USA.
Michael BoehnkeCenter for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, USA.
Ingrid B BoreckiDepartment of Genetics, Washington University School of Medicine, St. Louis, Missouri, USA.
Mark I McCarthy1] Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK. [2] Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK. [3] Oxford NIHR Biomedical Research Centre, Oxford University Hospitals NHS Trust, Oxford, UK.
Andres Metspalu1] Estonian Genome Center, University of Tartu, Tartu, Estonia. [2] Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia.
Kari Stefansson1] deCODE Genetics, Amgen, Inc., Reykjavik, Iceland. [2] Faculty of Medicine, University of Iceland, Reykjavik, Iceland.
André G Uitterlinden1] Department of Internal Medicine, Erasmus Medical Center, Rotterdam, the Netherlands. [2] Netherlands Consortium for Healthy Aging (NCHA), Rotterdam, the Netherlands. [3] Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.
Cornelia M van Duijn1] Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands. [2] Netherlands Consortium for Healthy Aging (NCHA), Rotterdam, the Netherlands. [3] Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands. [4] Center for Medical Systems Biology, Leiden, the Netherlands.
Lude FrankeDepartment of Genetics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
Cristen J Willer1] Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan, USA. [2] Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, Michigan, USA. [3] Department of Human Genetics, University of Michigan, Ann Arbor, Michigan, USA.
Alkes L Price1] Broad Institute of MIT and Harvard University, Cambridge, Massachusetts, USA. [2] Department of Epidemiology, Harvard School of Public Health, Harvard University, Boston, Massachusetts, USA. [3] Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, USA.
Guillaume Lettre1] Montreal Heart Institute, Montreal, Quebec, Canada. [2] Montreal Heart Institute, Université de Montréal, Montreal, Quebec, Canada.
Ruth J F Loos1] Medical Research Council (MRC) Epidemiology Unit, University of Cambridge, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK. [2] Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA. [3] Genetics of Obesity and Related Metabolic Traits Program, Icahn School of Medicine at Mount Sinai, New York, New York, USA. [4] Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Michael N WeedonGenetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, UK.
Erik Ingelsson1] Science for Life Laboratory, Uppsala University, Uppsala, Sweden. [2] Department of Medical Sciences, Molecular Epidemiology, Uppsala University, Uppsala, Sweden. [3] Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.
Jeffrey R O'Connell1] Program for Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA. [2] Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Goncalo R AbecasisCenter for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, USA.
Daniel I Chasman1] Division of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA. [2] Harvard Medical School, Boston, Massachusetts, USA.
Michael E Goddard1] Biosciences Research Division, Department of Primary Industries, Melbourne, Victoria, Australia. [2] Department of Food and Agricultural Systems, University of Melbourne, Melbourne, Victoria, Australia.
Peter M Visscher1] Queensland Brain Institute, University of Queensland, Brisbane, Queensland, Australia. [2] University of Queensland Diamantina Institute, Translation Research Institute, Brisbane, Queensland, Australia.
Joel N Hirschhorn1] Division of Endocrinology, Genetics and Basic and Translational Obesity Research, Boston Children's Hospital, Boston, Massachusetts, USA. [2] Broad Institute of MIT and Harvard University, Cambridge, Massachusetts, USA. [3] Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA.
Timothy M FraylingGenetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, UK.
University Medical Center Groningen · NLCentre for Human Genetics · GBNational Institutes of Health · USWashington University in St. Louis · USFinnish Institute for Health and Welfare · FIHelmholtz Zentrum München · DEErasmus MC · NLUppsala University · SEUniversitätsmedizin Greifswald · DEUniversity of Cambridge · GBKarolinska Institutet · SELeiden University Medical Center · NLUniversity Medical Center Utrecht · NLUniversity of Eastern Finland · FIUniversity of Michigan · USUniversity of Tartu · EEBrigham and Women's Hospital · USUniversity of Edinburgh · GBCentre National de la Recherche Scientifique · FRGerman Centre for Cardiovascular Research · DE
Funding
Translational Bioimaging Core Shared ResourceP30CA015704 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Marian Esvelt · 1985 to 2026
$296.4MUCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0MUniversity of Hawaii Cancer Center CCSGP30CA071789 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI Xin Chen · 1996 to 2026
$56.2MTransgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI PETER J TONTONOZ · 2003 to 2026
$40.4MSYNAPTIC MECHANISMS IN HIPPOCAMPAL EPILEPTOGENESISP30HD018655 · NICHD · CHILDREN'S HOSPITAL BOSTON · PI POMEROY, SCOTT LOREN · 1985 to 2015
$26.2MResearch BaseP30DK072488 · NIDDK · UNIVERSITY OF MARYLAND BALTIMORE · PI MITCHELL, BRAXTON D, TAYLOR, SIMEON I. · 2005 to 2019
$17.3MCell Interactions in the Inflamed Intestinal MucosaR01DK075787 · NIDDK · BOSTON CHILDREN'S HOSPITAL · PI JOEL N HIRSCHHORN · 2007 to 2026
$13.1MDetection of Colorectal Cancer Susceptibility Loci Using Genome-Wide SequencingU01CA164930 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI PETERS, ULRIKE · 2012 to 2015
$12.4MIdentifying Genes for Type 2 Diabetes: FUSIONU01DK062370 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BOEHNKE, MICHAEL L, SCOTT, LAURA J. · 2009 to 2021
$11.6MTargeted Genetic Analysis of T2D and Quantitative TraitsR01DK072193 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KAREN L. MOHLKE · 2005 to 2026
$11.3MStudies of Rare Genetic Variation in the Isolated Population of SardiniaR01HL117626 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ABECASIS, GONCALO · 2013 to 2016
$10.5MVanderbilt/Meharry Initiative for Minority Student DvptR25GM062459 · NIGMS · VANDERBILT UNIVERSITY · PI VELEZ EDWARDS, DIGNA R · 2002 to 2020
$10.4MBritish Heart Foundation FS/11/35/28871British Heart Foundation FS/12/33/29561British Heart Foundation FS/12/8/29377British Heart Foundation FS/14/12/30540British Heart Foundation PG/07/085/23349British Heart Foundation RG/08/008/25291British Heart Foundation RG/08/014/24067British Heart Foundation RG/09/012/28096British Heart Foundation RG/10/12/28456British Heart Foundation SP/08/002/24118Chief Scientist Office CZB/4/672Chief Scientist Office CZB/4/710Department of Health RP-PG-0310-1002European Research Council 323195Medical Research Council G0500070Medical Research Council G0601463Medical Research Council G1002084Medical Research Council MC_PC_U127561128Medical Research Council MC_U106179471Medical Research Council MC_U106179472Medical Research Council MC_UP_A100_1003Medical Research Council MC_UU_12015/1Medical Research Council MC_UU_12015/2Medical Research Council MC_UU_12015/5Medical Research Council MC_UU_12019/1Medical Research Council MR/K006584/1Medical Research Council MR/K013351/1Medical Research Council MR/L003120/1Medical Research Council MR/L01629X/1NCATS NIH HHS UL1 TR000124NCI NIH HHS P30 CA015704NCI NIH HHS P30 CA071789NCI NIH HHS U01 CA164930NHGRI NIH HHS U01 HG007419NHLBI NIH HHS R01 HL087700NHLBI NIH HHS R01 HL088215NHLBI NIH HHS R01 HL109946NHLBI NIH HHS R01 HL117078NHLBI NIH HHS R01 HL117626NHLBI NIH HHS T32 HL007055NICHD NIH HHS P30 HD018655NIDDK NIH HHS P30 DK063491NIDDK NIH HHS P30 DK072488NIDDK NIH HHS R01 DK072193NIDDK NIH HHS R01 DK075787NIDDK NIH HHS R01 DK093757NIDDK NIH HHS U01 DK062370NIGMS NIH HHS P01 GM099568NIGMS NIH HHS P30 GM103341NIGMS NIH HHS R01 GM075091NIGMS NIH HHS R25 GM062459NIGMS NIH HHS T32 GM080178Wellcome Trust 085301Wellcome Trust 090532Wellcome Trust 098381Wellcome Trust 098395
Abstract
Using genome-wide data from 253,288 individuals, we identified 697 variants at genome-wide significance that together explained one-fifth of the heritability for adult height. By testing different numbers of variants in independent studies, we show that the most strongly associated ∼2,000, ∼3,700 and ∼9,500 SNPs explained ∼21%, ∼24% and ∼29% of phenotypic variance. Furthermore, all common variants together captured 60% of heritability. The 697 variants clustered in 423 loci were enriched for genes, pathways and tissue types known to be involved in growth and together implicated genes and pathways not highlighted in earlier efforts, such as signaling by fibroblast growth factors, WNT/β-catenin and chondroitin sulfate-related genes. We identified several genes and pathways not previously connected with human skeletal growth, including mTOR, osteoglycin and binding of hyaluronic acid. Our results indicate a genetic architecture for human height that is characterized by a very large but finite number (thousands) of causal variants.
Indexed as
AdultAnalysis of VarianceBody HeightGenetics, PopulationGenetic VariationGenome-Wide Association StudyHumansOligonucleotide Array Sequence AnalysisPolymorphism, Single NucleotideWhite People
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