ArticleNature genetics2014
Recombination drives genome evolution in outbreak-related Legionella pneumophila isolates.
Article in Nature genetics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.
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Who cites it
57 citing papers in PubMed, 87 citations in OpenAlex.
- Article
- Impact of Natural Transformation on the Acquisition of Novel Genes in Bacteria.Molecular biology and evolution · 2025Article
- Comparative genome analysis investigation of nosocomial and community-acquired cases of Legionnaires' disease caused by ST2858 and ST378.Microbiology spectrum · 2025Article
- Strain tracking in complex microbiomes using synteny analysis reveals per-species modes of evolution.Nature biotechnology · 2025Article
- Genomic analysis ofMicrobial genomics · 2025Article
- Insights into Treponema pallidum genomics from modern and ancient genomes using a novel mapping strategy.BMC biology · 2025Article
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- Expanded geographic distribution for twomSphere · 2024Article
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- Rapid adaptations ofMicrobial genomics · 2023Article
- Presence of Viable, Clinically RelevantMicrobiology spectrum · 2022Article
- The molecular basis of FimT-mediated DNA uptake during bacterial natural transformation.Nature communications · 2022Article
- Evolutionary Processes in the Emergence and Recent Spread of the Syphilis Agent, Treponema pallidum.Molecular biology and evolution · 2022Article
- Core and Accessory Genome Analysis ofMicroorganisms · 2021Article
- Transposon Insertion Sequencing in a Clinical Isolate of Legionella pneumophila Identifies Essential Genes and Determinants of Natural Transformation.Journal of bacteriology · 2021Article
- Quantifying the transmission of antimicrobial resistance at the human and livestock interface with genomics.Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases · 2020Review
- Type I-F CRISPR-Cas Distribution and Array Dynamics inG3 (Bethesda, Md.) · 2020Article
- An Evolutionary Arms Race BetweenFrontiers in microbiology · 2020Review
- Diverse conjugative elements silence natural transformation inProceedings of the National Academy of Sciences of the United States of America · 2019Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Legionella pneumophila is a strictly environmental pathogen and the etiological agent of legionellosis. It is known that non-vertical processes have a major role in the short-term evolution of pathogens, but little is known about the relevance of these and other processes in environmental bacteria. We report the whole-genome sequencing of 69 L. pneumophila strains linked to recurrent outbreaks in a single location (Alcoy, Spain) over 11 years. We found some examples where the genome sequences of isolates of the same sequence type and outbreak did not cluster together and were more closely related to sequences from different outbreaks. Our analyses identify 16 recombination events responsible for almost 98% of the SNPs detected in the core genome and an apparent acceleration in the evolutionary rate. These results have profound implications for the understanding of microbial populations and for public health interventions in Legionella outbreak investigations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.