Evidence map›Paper›PMID 25281959›Full record

ArticleMedical physics2014

Cascaded systems analysis of photon counting detectors.

J Xu, W Zbijewski, G Gang, J W Stayman, K Taguchi, M Lundqvist, E Fredenberg, J A Carrino, J H Siewerdsen

Abstract readValidation Study
In one paragraph

Article in Medical physics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed.

  1. Article
  2. Framework for evaluating photon-counting detectors under pile-up conditions.Journal of medical imaging (Bellingham, Wash.) · 2024
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Spectral Photon Counting CT: Imaging Algorithms and Performance Assessment.IEEE transactions on radiation and plasma medical sciences · 2021
    Article
  8. Article
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  18. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

J XuDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland 21205.
W ZbijewskiDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland 21205.
G GangDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland 21205.
J W StaymanDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland 21205.
K TaguchiRussell H. Morgan Department of Radiology, Johns Hopkins University, Baltimore, Maryland 21205.
M LundqvistPhilips Healthcare, Solna 171 41, Sweden.
E FredenbergPhilips Healthcare, Solna 171 41, Sweden.
J A CarrinoRussell H. Morgan Department of Radiology, Johns Hopkins University, Baltimore, Maryland 21205.
J H SiewerdsenDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland 21205Russell H. Morgan Department of Radiology, Johns Hopkins University, Baltimore, Maryland 21205.

Funding

Image Science for the New X-ray: Taking NEQ to TaskR01CA112163 · NCI · UNIVERSITY HEALTH NETWORK · PI SIEWERDSEN, JEFFREY H · 2006 to 2014
$2.1M
Training Program in Translational Research in ImagingT32EB010021 · NIBIB · JOHNS HOPKINS UNIVERSITY · PI MCVEIGH, ELLIOT R · 2010 to 2014
$1.6M
NCI NIH HHS 2R01-CA-112163NCI NIH HHS R01 CA112163NIBIB NIH HHS T32 EB010021NIBIB NIH HHS T32EB010021
6 · The paper itself

Abstract

purposePhoton counting detectors (PCDs) are an emerging technology with applications in spectral and low-dose radiographic and tomographic imaging. This paper develops an analytical model of PCD imaging performance, including the system gain, modulation transfer function (MTF), noise-power spectrum (NPS), and detective quantum efficiency (DQE).

methodsA cascaded systems analysis model describing the propagation of quanta through the imaging chain was developed. The model was validated in comparison to the physical performance of a silicon-strip PCD implemented on an experimental imaging bench. The signal response, MTF, and NPS were measured and compared to theory as a function of exposure conditions (70 kVp, 1-7 mA), detector threshold, and readout mode (i.e., the option for coincidence detection). The model sheds new light on the dependence of spatial resolution, charge sharing, and additive noise effects on threshold selection and was used to investigate the factors governing PCD performance, including the fundamental advantages and limitations of PCDs in comparison to energy-integrating detectors (EIDs) in the linear regime for which pulse pileup can be ignored.

resultsThe detector exhibited highly linear mean signal response across the system operating range and agreed well with theoretical prediction, as did the system MTF and NPS. The DQE analyzed as a function of kilovolt (peak), exposure, detector threshold, and readout mode revealed important considerations for system optimization. The model also demonstrated the important implications of false counts from both additive electronic noise and charge sharing and highlighted the system design and operational parameters that most affect detector performance in the presence of such factors: for example, increasing the detector threshold from 0 to 100 (arbitrary units of pulse height threshold roughly equivalent to 0.5 and 6 keV energy threshold, respectively), increased the f50 (spatial-frequency at which the MTF falls to a value of 0.50) by ∼30% with corresponding improvement in DQE. The range in exposure and additive noise for which PCDs yield intrinsically higher DQE was quantified, showing performance advantages under conditions of very low-dose, high additive noise, and high fidelity rejection of coincident photons.

conclusionsThe model for PCD signal and noise performance agreed with measurements of detector signal, MTF, and NPS and provided a useful basis for understanding complex dependencies in PCD imaging performance and the potential advantages (and disadvantages) in comparison to EIDs as well as an important guide to task-based optimization in developing new PCD imaging systems.

Indexed as

Models, TheoreticalPhotonsAlgorithmsDiagnostic ImagingFourier AnalysisSignal-To-Noise RatioX-Rays

Identifiers

PMID25281959
PMCPMC4281040

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.