ReviewGenomics2014
The enduring utility of continuous culturing in experimental evolution.
Review in Genomics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
68 citing papers in PubMed.
- An Analytical Framework for Phenotypic Selection of Fitness-Conferring Genes.Bulletin of mathematical biology · 2026Article
- Segmental copy number amplifications are more stable than aneuploidies in the absence of selection.Molecular biology and evolution · 2026Article
- Acid adaptation of Lactobacillus helveticus during continuous cultures to improve undissociated lactic acid production.Bioresources and bioprocessing · 2026Article
- Article
- Adaptive Laboratory Evolution of Pichia pastoris by Serial Batch Cultivation.Methods in molecular biology (Clifton, N.J.) · 2026Article
- Population-level bistability inmBio · 2025Article
- A Bioprocess Engineering Approach to Boost Selection of Fully Segregated Transformants in Cyanobacteria.Biotechnology and bioengineering · 2025Article
- rDNA copy number variation affects yeast fitness in response to different environments.Genetics · 2025Article
- Phosphorelay changes and plasticity underlie the life history evolution ofMicrobiology (Reading, England) · 2025Article
- Multilevel Gene Expression Changes in Lineages Containing Adaptive Copy Number Variants.Molecular biology and evolution · 2025Article
- Strain-specific metabarcoding reveals rapid evolution of copper tolerance in populations of the coastal diatom Skeletonema marinoi.Molecular ecology · 2024Article
- Microfluidics for adaptation of microorganisms to stress: design and application.Applied microbiology and biotechnology · 2024Review
- Article
- Mutation bias and adaptation in bacteria.Microbiology (Reading, England) · 2023Review
- Article
- Equilibria and oscillations in cheat-cooperator dynamics.Evolution letters · 2023Article
- Long-term evolution of proliferating cells using the eVOLVER platform.Open biology · 2023Article
- Best Practices in Microbial Experimental Evolution: Using Reporters and Long-Read Sequencing to Identify Copy Number Variation in Experimental Evolution.Journal of molecular evolution · 2023Review
- Metabolic adaptation to consume butyrate under prolonged resource exhaustion.PLoS genetics · 2023Article
- Article
8 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Studying evolution in the laboratory provides a means of understanding the processes, dynamics and outcomes of adaptive evolution in precisely controlled and readily replicated conditions. The advantages of experimental evolution are maximized when the selection is well defined, which enables linking genotype, phenotype and fitness. One means of maintaining a defined selection is continuous culturing: chemostats enable the study of adaptive evolution in constant nutrient-limited environments, whereas cells in turbidostats evolve in constant nutrient abundance. Although the experimental effort required for continuous culturing is considerable relative to the experimental simplicity of serial batch culture, the opposite is true of the environments they produce: continuous culturing results in simplified and invariant conditions whereas serially diluted batch cultures are complex and dynamic. The comparative simplicity of the selective environment that is unique to continuous culturing provides an ideal experimental system for addressing key questions in adaptive evolution.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.