ArticleThe Journal of physiology2014
Skeletal muscle ATP turnover by 31P magnetic resonance spectroscopy during moderate and heavy bilateral knee extension.
Article in The Journal of physiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 72 citations in OpenAlex.
- Pooled it
- Skeletal muscle ATP synthesis and cellular H(+) handling measured by localized (31)P-MRS during exercise and recovery.Scientific reports · 2016Trial
- Mechanisms of Attenuation of Pulmonary V'O2 Slow Component in Humans after Prolonged Endurance Training.PloS one · 2016Trial
- On the adaptive significance of group III/IV muscle afferent feedback for the cardiovascular response during sustained locomotion in humans.The Journal of physiology · 2026Article
- Durability of Parameters Associated With Endurance Running in Marathoners.European journal of sport science · 2025Article
- Higher legs muscle mass reduces gross mechanical efficiency during moderate intensity cycling in young healthy men.Scientific reports · 2025Article
- Energy balance analysis suggests that lactate is not a direct cause of the slow component of oxygen uptake kinetics.European journal of applied physiology · 2025Article
- Biochemical origin of (near-) linear curvature constant (W')-European journal of applied physiology · 2025Article
- Numerous Trigger-like Interactions of Kinases/Protein Phosphatases in Human Skeletal Muscles Can Underlie Transient Processes in Activation of Signaling Pathways during Exercise.International journal of molecular sciences · 2023Review
- Skeletal muscle biochemical origin of exercise intensity domains and their relation to whole-body V̇O2 kinetics.Bioscience reports · 2022Article
- A Modular Mathematical Model of Exercise-Induced Changes in Metabolism, Signaling, and Gene Expression in Human Skeletal Muscle.International journal of molecular sciences · 2021Article
- Quantifying HPhysiological reports · 2021Article
- Exercise rescues mitochondrial coupling in aged skeletal muscle: a comparison of different modalities in preventing sarcopenia.Journal of translational medicine · 2021Review
- Exceeding a "critical" muscle PEuropean journal of applied physiology · 2020Article
- Relationship between recovery of neuromuscular function and subsequent capacity to work above critical power.European journal of applied physiology · 2020Article
- Alterations to neuromuscular properties of skeletal muscle are temporally dissociated from the oxygen uptake slow component.Scientific reports · 2020Article
- PEuropean journal of applied physiology · 2019Article
- The relationship between peripheral muscle strength and respiratory function and respiratory muscle strength in athletes.Journal of exercise rehabilitation · 2019Article
- The Slow Component of Oxygen Uptake and Efficiency in Resistance Exercises: A Comparison With Endurance Exercises.Frontiers in physiology · 2019Article
- Regulation of oxidative phosphorylation is different in electrically- and cortically-stimulated skeletal muscle.PloS one · 2018Article
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Authors and funding
8 authors at 6 institutions in 3 countries.
Funding
Abstract
During constant-power high-intensity exercise, the expected increase in oxygen uptake (V̇O2) is supplemented by a V̇O2 slow component (V̇O2 sc ), reflecting reduced work efficiency, predominantly within the locomotor muscles. The intracellular source of inefficiency is postulated to be an increase in the ATP cost of power production (an increase in P/W). To test this hypothesis, we measured intramuscular ATP turnover with (31)P magnetic resonance spectroscopy (MRS) and whole-body V̇O2 during moderate (MOD) and heavy (HVY) bilateral knee-extension exercise in healthy participants (n = 14). Unlocalized (31)P spectra were collected from the quadriceps throughout using a dual-tuned ((1)H and (31)P) surface coil with a simple pulse-and-acquire sequence. Total ATP turnover rate (ATPtot) was estimated at exercise cessation from direct measurements of the dynamics of phosphocreatine (PCr) and proton handling. Between 3 and 8 min during MOD, there was no discernable V̇O2 sc (mean ± SD, 0.06 ± 0.12 l min(-1)) or change in [PCr] (30 ± 8 vs. 32 ± 7 mm) or ATPtot (24 ± 14 vs. 17 ± 14 mm min(-1); each P = n.s.). During HVY, the V̇O2 sc was 0.37 ± 0.16 l min(-1) (22 ± 8%), [PCr] decreased (19 ± 7 vs. 18 ± 7 mm, or 12 ± 15%; P < 0.05) and ATPtot increased (38 ± 16 vs. 44 ± 14 mm min(-1), or 26 ± 30%; P < 0.05) between 3 and 8 min. However, the increase in ATPtot (ΔATPtot) was not correlated with the V̇O2 sc during HVY (r(2) = 0.06; P = n.s.). This lack of relationship between ΔATPtot and V̇O2 sc , together with a steepening of the [PCr]-V̇O2 relationship in HVY, suggests that reduced work efficiency during heavy exercise arises from both contractile (P/W) and mitochondrial sources (the O2 cost of ATP resynthesis; P/O).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.