ArticleCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology2014
Alcohol consumption in relation to plasma sex hormones, prolactin, and sex hormone-binding globulin in premenopausal women.
Article in Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 60 citations in OpenAlex.
- A meta-analysis of alcohol consumption and thyroid cancer risk.Oncotarget · 2016Pooled it
- Hormone-associated dietary patterns and premenopausal breast cancer risk.Breast cancer research and treatment · 2025Article
- Estrogen and alcohol use in women: a targeted literature review.Archives of women's mental health · 2025Review
- Genetic correlations of alcohol consumption and alcohol use disorder with sex hormone levels in females and males.Frontiers in psychiatry · 2025Article
- Rapid nongenomic estrogen signaling controls alcohol drinking behavior in mice.Nature communications · 2024Article
- The role of neurosteroids in posttraumatic stress disorder and alcohol use disorder: A review of 10 years of clinical literature and treatment implications.Frontiers in neuroendocrinology · 2024Review
- Preliminary evidence of increased alcohol use associated with ethinyl estradiol levels in women using oral contraceptives.Drug and alcohol dependence reports · 2023Article
- Unveiling the effect of estrogen receptors in alcoholic liver disease: A novel outlook.Liver research (Beijing, China) · 2023Review
- Case report on gynecomastia with ipsilateral recurrence of granulomatous lobular mastitis.The Journal of international medical research · 2023Article
- Associations of sex-related steroid hormones and proteins with alcohol dependence: A United Kingdom Biobank study.Drug and alcohol dependence · 2023Article
- Alcohol and breast cancer.Pharmacological reports : PR · 2023Review
- Mammographic breast density status in women aged more than 40 years in Sulaimaniyah, Iraq: a cross-sectional study.The Journal of international medical research · 2022Article
- Reduced Dehydroepiandrosterone-Sulfate Levels in the Mid-Luteal Subphase of the Menstrual Cycle: Implications to Women's Health Research.Metabolites · 2022Article
- Alcohol Intake and Endogenous Hormones in Pre- and Postmenopausal Women: Findings from the UK Biobank.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2021Article
- Evaluating the genetic effects of sex hormone traits on the development of mental traits: a polygenic score analysis and gene-environment-wide interaction study in UK Biobank cohort.Molecular brain · 2021Article
- Proteomic Profiling of Exosomes Derived from Plasma of HIV-Infected Alcohol Drinkers and Cigarette Smokers.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2020Article
- Alcohol consumption and serum metabolite concentrations in young women.Cancer causes & control : CCC · 2020Article
- Alcohol's Effects on Breast Cancer in Women.Alcohol research : current reviews · 2020Review
- Number of Risky Lifestyle Behaviors and Breast Cancer Risk.JNCI cancer spectrum · 2018Article
- Circulating Hormones and Mammographic Density in Premenopausal Women.Hormones & cancer · 2018Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
backgroundAlcohol consumption is a consistent risk factor for breast cancer, and evidence suggests premenopausal plasma hormones are associated with breast cancer.
methodsPlasma concentrations of estradiol, estrone, estrone sulfate, testosterone, androstenedione, progesterone, prolactin, dehydroepiandrosterone (DHEA), dehydroepiandrosterone sulfate (DHEAS), and sex hormone-binding globulin (SHBG) were measured in samples collected in 1996-99. Average alcohol intake was calculated from semiquantitative food frequency questionnaires collected in 1995 and 1999. We used generalized linear models to calculate geometric mean hormone concentrations across alcohol categories and the percentage difference for the highest versus lowest category.
resultsComparing women who consumed >20 g/d with nondrinkers, levels were 25.7% higher for luteal estrone (geometric mean, 106 vs. 84.5 pg/mL; Ptrend = 0.001), 27.2% higher for luteal estradiol (182 vs. 143 pg/mL; Ptrend = 0.006), and 16.8% higher for SHBG (85.6 vs. 73.3 nmol/L; Ptrend = 0.03); concentrations of free testosterone were 17.9% lower (0.16 vs. 0.20 ng/dL; Ptrend = 0.002). Women consuming >10 g/d compared with nondrinkers had 26.5% higher concentrations of follicular estrone sulfate (950 vs. 751 pg/mL; Ptrend = 0.04). We did not observe significant associations between alcohol and the other sex hormones evaluated. Significant positive associations were observed with beer intake, but not other alcohol types, for DHEA (Pinteraction = 0.003) and androstenedione (Pinteraction = 0.006).
conclusionAlcohol consumption was significantly positively associated with plasma luteal estrogen concentrations, but not with androgen levels, nor estrone or estradiol measured in the follicular phase. IMPACT: Differences in premenopausal estrogen levels may contribute to the association between alcohol and breast cancer.
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