Evidence map›Paper›PMID 25281358›Full record

ReviewSeminars in perinatology2014

Oseltamivir for influenza in pregnancy.

Richard H Beigi, Raman Venkataramanan, Steve N Caritis

Abstract readReview
In one paragraph

Review in Seminars in perinatology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.6field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 23 citations in OpenAlex.

  1. Efficacy of oseltamivir compared with zanamivir in COPD patients with seasonal influenza virus infection: a randomized controlled trial.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Richard H BeigiDepartment of Obstetrics, Gynecology, and Reproductive Sciences, Magee-Womens Hospital of the University of Pittsburgh Medical Center, 300 Halket St, Pittsburgh, PA 15213. Electronic address: rbeigi@mail.magee.edu.
Raman VenkataramananDepartment of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA; Department of Pathology, School of Medicine, University of Pittsburgh, Pittsburgh, PA.
Steve N CaritisDepartment of Obstetrics, Gynecology, and Reproductive Sciences, Magee-Womens Hospital of the University of Pittsburgh Medical Center, 300 Halket St, Pittsburgh, PA 15213.
Magee-Womens Hospital · USUniversity of Pittsburgh · US

Funding

Pregnancy and Drug Metabolizing Enzymes and TransportersU10HD047905 · NICHD · MAGEE-WOMEN'S RES INST AND FOUNDATION · PI CARITIS, STEVE N · 2004 to 2014
$9.7M
UW Obstetric-Fetal Pharmacology Research UnitU10HD047892 · NICHD · UNIVERSITY OF WASHINGTON · PI EASTERLING, THOMAS R, HEBERT, MARY F · 2004 to 2014
$9.4M
Obstetric Pharmacology Research Units Network Center at UTMB-GalvestonU10HD047891 · NICHD · UNIVERSITY OF TEXAS MEDICAL BR GALVESTON · PI AHMED, MAHMOUD S, HANKINS, GARY D · 2004 to 2014
$9.3M
UTMB OPRC Administrative CoreU54HD047891 · NICHD · UNIVERSITY OF TEXAS MED BR GALVESTON · PI DUKES, KIMBERLY A. · 2015 to 2019
$4.8M
Optimization of Drug Dosing in Pregnant Women through Research and EducationU54HD047905 · NICHD · MAGEE-WOMEN'S RES INST AND FOUNDATION · PI VENKATARAMANAN, RAMAN · 2015 to 2019
$3.7M
NICHD NIH HHS HD047891NICHD NIH HHS HD047892NICHD NIH HHS HD047905NICHD NIH HHS U10 HD047891NICHD NIH HHS U10 HD047892NICHD NIH HHS U10 HD047905NICHD NIH HHS U54 HD047891NICHD NIH HHS U54 HD047905
6 · The paper itself

Abstract

Pregnancy predisposes women to disproportionate morbidity and mortality from influenza infections. This is true for both seasonal epidemics as well as occasional pandemics. Inactivated yearly influenza vaccines are the best available method of disease prevention and are recommended for all pregnant women in any trimester of pregnancy and postpartum. Oseltamivir (Tamiflu(®)) is currently the first-line recommended and most commonly used pharmaceutical agent for influenza prophylaxis and treatment. Oseltamivir has been demonstrated to prevent disease among exposed individuals, as well as to shorten the duration of illness and lessen the likelihood of complications among those infected. The physiologic adaptations of pregnancy may alter the pharmacokinetics and pharmacodynamics of this important drug. Updated evidence regarding these potential alterations, current knowledge gaps, and future investigative directions is discussed.

Indexed as

Antiviral AgentsFemaleHumansInfluenza, HumanOseltamivirPregnancyPregnancy Complications, InfectiousAntiviral AgentsOseltamivirInfluenzaOseltamivirPharmacologyPregnancy

Identifiers

PMID25281358
PMCPMC5745365
OpenAlexW2050553264

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.