ReviewSeminars in perinatology2014
Basic obstetric pharmacology.
Review in Seminars in perinatology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.
- Reproductive Decision-Making Capacity in Women With Psychiatric Illness: A Systematic Review.Journal of the Academy of Consultation-Liaison PsychiatryPooled it
- A White Paper on Advancing Long-Acting Therapeutics for Maternal and Pediatric Health by Bridging Gaps in Clinical Research, Access and Regulation.Clinical pharmacology and therapeutics · 2026Review
- Adverse Drug Reactions in Pregnant People with Hypertension and/or Diabetes: Temporal Profile and Associated Factors.The Canadian journal of hospital pharmacy · 2025Article
- Genetic Insights Into Perinatal Outcomes of Maternal Antihypertensive Therapy During Pregnancy.JAMA network open · 2024Article
- The Use of the Target Trial Approach in Perinatal Pharmacoepidemiology: A Scoping Review Protocol.Frontiers in pharmacology · 2022Article
- Anatomical and physiological alterations of pregnancy.Journal of pharmacokinetics and pharmacodynamics · 2020Review
- Pharmacokinetic studies in pregnancy.Seminars in perinatology · 2020Review
- Pregnancy Alters CYP- and UGT-Mediated Metabolism of Buprenorphine.Therapeutic drug monitoring · 2020Article
- Evaluation of Fetal and Maternal Vancomycin-Induced Kidney Injury during Pregnancy in a Rat Model.Antimicrobial agents and chemotherapy · 2019Article
- The impact of exposure to antidepressant medications during pregnancy on neonatal outcomes: a review of retrospective database cohort studies.European journal of clinical pharmacology · 2017Review
- Ondansetron Exposure Changes in a Pregnant Woman.Pharmacotherapy · 2016Article
- The Treatment of Colorectal Cancer During Pregnancy: Cytotoxic Chemotherapy and Targeted Therapy Challenges.The oncologist · 2016Review
- Management of epilepsy during pregnancy: an update.Therapeutic advances in neurological disorders · 2016Review
- Developing and Using Therapeutics for Emerging Infections.Clinical pharmacology and therapeutics · 2015Article
- [Anesthesia and pain management during pregnancy].Der Anaesthesist · 2015Review
- Special population considerations and regulatory affairs for clinical research.Clinical research and regulatory affairsArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 1 country.
Funding
Abstract
Pregnancy is associated with a variety of physiological changes that can alter the pharmacokinetics and pharmacodynamics of several drugs. However, limited data exists on the pharmacokinetics and pharmacodynamics of the majority of the medications used in pregnancy. In this article, we first describe basic concepts (drug absorption, bioavailability, distribution, metabolism, elimination, and transport) in pharmacokinetics. Then, we discuss several physiological changes that occur during pregnancy that theoretically affect absorption, distribution, metabolism, and elimination. Further, we provide a brief review of the literature on the clinical pharmacokinetic studies performed in pregnant women in recent years. In general, pregnancy increases the clearance of several drugs and correspondingly decreases drug exposure during pregnancy. Based on current drug exposure measurements during pregnancy, alterations in the dose or dosing regimen of certain drugs are essential during pregnancy. More pharmacological studies in pregnant women are needed to optimize drug therapy in pregnancy.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.