ArticleNitric oxide : biology and chemistry2015
Microvascular oxygen pressures in muscles comprised of different fiber types: Impact of dietary nitrate supplementation.
Article in Nitric oxide : biology and chemistry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
56 citing papers in PubMed, 2 syntheses or guidelines pooled it, 117 citations in OpenAlex.
- Effects of Beetroot Juice on Physical Performance in Professional Athletes and Healthy Individuals: An Umbrella Review.Nutrients · 2025Pooled it
- The Effect of Beetroot Ingestion on High-Intensity Interval Training: A Systematic Review and Meta-Analysis.Nutrients · 2021Pooled it
- Influence of Acute Beetroot Juice Intake on Agility Performance Immediately Post-Repeated Maximal Sprinting in Soccer Players.Nutrients · 2026Trial
- Trial
- Preworkout dietary nitrate magnifies training-induced benefits to physical function in late postmenopausal women: a randomized pilot study.American journal of physiology. Regulatory, integrative and comparative physiology · 2024Trial
- A Single Dose of Beetroot Juice not Enhance Performance during Intervallic Swimming Efforts.Journal of sports science & medicine · 2024Trial
- The effects of inorganic nitrate supplementation on exercise economy and endurance capacity across the menstrual cycle.Journal of applied physiology (Bethesda, Md. : 1985) · 2023Trial
- The acute effects of exercise intensity and inorganic nitrate supplementation on vascular health in females after menopause.Journal of applied physiology (Bethesda, Md. : 1985) · 2023Trial
- Effects of Beetroot Juice Supplementation on Cognitive Function, Aerobic and Anaerobic Performances of Trained Male Taekwondo Athletes: A Pilot Study.International journal of environmental research and public health · 2021Trial
- The effect of dietary nitrate on exercise capacity in chronic kidney disease: a randomized controlled pilot study.Nitric oxide : biology and chemistry · 2021Trial
- Dietary nitrate does not acutely enhance skeletal muscle blood flow and vasodilation in the lower limbs of older adults during single-limb exercise.European journal of applied physiology · 2020Trial
- A Single Dose of Dietary Nitrate Increases Maximal Knee Extensor Angular Velocity and Power in Healthy Older Men and Women.The journals of gerontology. Series A, Biological sciences and medical sciences · 2020Trial
- Effects of Beetroot Juice Ingestion on Physical Performance in Highly Competitive Tennis Players.Nutrients · 2020Trial
- Effects of chronic beetroot juice supplementation on maximum oxygen uptake, velocity associated with maximum oxygen uptake, and peak velocity in recreational runners: a double-blinded, randomized and crossover study.European journal of applied physiology · 2019Trial
- Dietary nitrate-induced increases in human muscle power: high versus low responders.Physiological reports · 2018Trial
- Acute ingestion of dietary nitrate increases muscle blood flow via local vasodilation during handgrip exercise in young adults.Physiological reports · 2018Trial
- Dietary nitrate supplementation enhances short but not longer duration running time-trial performance.European journal of applied physiology · 2017Trial
- Differential vascular reactivity responses acutely following ingestion of a nitrate rich red spinach extract.European journal of applied physiology · 2016Trial
- Effects of Beetroot Juice on Recovery of Muscle Function and Performance between Bouts of Repeated Sprint Exercise.Nutrients · 2016Trial
- Influence of beetroot juice supplementation on intermittent exercise performance.European journal of applied physiology · 2016Trial
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
Nitrate (NO3(-)) supplementation via beetroot juice (BR) preferentially improves vascular conductance and O2 delivery to contracting skeletal muscles comprised predominantly of type IIb + d/x (i.e. highly glycolytic) fibers following its reduction to nitrite and nitric oxide (NO). To address the mechanistic basis for NO3(-) to improve metabolic control we tested the hypothesis that BR supplementation would elevate microvascular PO2 (PO2mv) in fast twitch but not slow twitch muscle. Twelve young adult male Sprague-Dawley rats were administered BR ([NO3(-)] 1 mmol/kg/day, n = 6) or water (control, n = 6) for 5 days. PO2mv (phosphorescence quenching) was measured at rest and during 180 s of electrically-induced 1-Hz twitch contractions (6-8 V) of the soleus (9% type IIb +d/x) and mixed portion of the gastrocnemius (MG, 91% type IIb + d/x) muscles. In the MG, but not the soleus, BR elevated contracting steady state PO2mv by ~43% (control: 14 ± 1, BR: 19 ± 2 mmHg (P < 0.05)). This higher PO2mv represents a greater blood-myocyte O2 driving force during muscle contractions thus providing a potential mechanism by which NO3(-) supplementation via BR improves metabolic control in fast twitch muscle. Recruitment of higher order type II muscle fibers is thought to play a role in the development of the VO2 slow component which is inextricably linked to the fatigue process. These data therefore provide a putative mechanism for the BR-induced improvements in high-intensity exercise performance seen in humans.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.