ArticleInternational archives of occupational and environmental health2015
Biological monitoring of exposure and effects in workers employed in a selenium-processing plant.
Article in International archives of occupational and environmental health, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 21 citations in OpenAlex.
- Functional Biomarkers for the Selenium Status in a Human Nutritional Intervention Study.Nutrients · 2020Trial
- Associations between Urinary and Dietary Selenium and Blood Metabolic Parameters in a Healthy Northern Italy Population.Antioxidants (Basel, Switzerland) · 2021Article
- Evaluation of urinary selenium as a biomarker of human occupational exposure to elemental and inorganic selenium.International archives of occupational and environmental health · 2020Article
- Environmental Selenium and Human Health: an Update.Current environmental health reports · 2018Review
- Health risk assessment of environmental selenium: Emerging evidence and challenges (Review).Molecular medicine reports · 2017Review
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe aim of the study was to assess external and internal selenium exposure and potential biological effects in employees working in a selenium-processing plant.
methodsTwenty male employees of a selenium-processing plant (exposed) and 20 age-matched male individuals without occupational selenium exposure (controls) participated in the study. Exposure to selenium at the workplace was determined by personal air sampling. Internal exposure was assessed by measuring total selenium concentration in plasma after a workshift and after holidays as well as by measuring the selenium concentration in urine before and after shift and after holidays. The activity of glutathione peroxidase (GPx) in blood and the prothrombin time were determined as biological effect parameters.
resultsThe exposure to selenium in the workplace air ranged from 8 to 950 µg/m(3) and exceeded in a large part current occupational exposure limits. The selenium levels in plasma samples of the exposed ranged from 49 to 182 µg/L during exposure and were significantly higher than the plasma levels observed after holidays as well as in the control group. The selenium concentration in pre- and post-shift urine samples did not differ significantly, and the average urinary selenium levels of the employees (18-1,104 µg/g creatinine) were significantly higher than those measured after holidays or determined in controls. Both the concentration of selenium in plasma and in urine did not correlate with the current external exposure of the employees at the workplace. However, we found a strong and significant association between the two biomonitoring parameters. In spite of the considerable high external exposure to elemental selenium, we did not find any effect on the GPx activity in blood as well as on the prothrombin time.
conclusionsBoth the selenium levels in plasma and urine may be used as biological monitoring parameters for the assessment of chronic occupational exposure to selenium. Nevertheless, the toxicokinetics of the urinary excretion of selenium remain still unclear and require further investigations. Moreover, our findings emphasise the necessity of a re-evaluation of occupational exposure limits for elemental selenium and inorganic selenium compounds.
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