Trial reportJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology2014
Feasibility and operator variability of myocardial blood flow and reserve measurements with ⁹⁹mTc-sestamibi quantitative dynamic SPECT/CT imaging.
Trial report in Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it.
- EANM practice guideline for quantitative SPECT-CT.European journal of nuclear medicine and molecular imaging · 2023Guideline
- Chronic remote ischemic conditioning treatment in patients with chronic stable angina (EARLY-MYO-CSA): a randomized, controlled proof-of-concept trial.BMC medicine · 2023Trial
- The Influence of Kinetic Models and Attenuation Correction on Cadmium-Zinc-Telluride Single-Photon Emission Computed Tomography (CZT SPECT)-Derived Myocardial Blood Flow and Reserve: Correlation with Invasive Angiography Data.Journal of clinical medicine · 2024Article
- Precision of Myocardial Blood Flow and Flow Reserve Measurement During CZT SPECT Perfusion Imaging Processing: Intra- and Interobserver Variability.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2023Article
- Myocardial blood flow quantitation with the SPECT technique: Where do we stand?Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2022Article
- SPECT quantification of myocardial blood flow: Another step toward widespread availability.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021Article
- Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021Article
- Quantification of myocardial blood flow by CZT-SPECT with motion correction and comparison withJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021Article
- The potential of regional myocardial blood flow measurement with SPECT.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021Article
- Assessment of cardiac amyloidosis withEJNMMI physics · 2021Article
- Myocardial blood flow quantitation in patients with congestive heart failure: head-to-head comparison between rapid-rotating gantry SPECT and CZT SPECT.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2020Article
- Cardiac impact of arteriovenous fistulas: what tools to assess?Heart and vessels · 2020Article
- Myocardial blood flow quantification conventional single photon tracers: Yet another critical appraisal : Atsutaka Okizaki et al: Noninvasive estimation of quantitative myocardial blood flow with Tc-99m MIBI by a compartment model analysis in rat.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2020Article
- The tools are ready, are we?Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2019Article
- Advances in imaging instrumentation for nuclear cardiology.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2019Review
- Comparison of sparse domain approaches for 4D SPECT dynamic image reconstruction.Medical physics · 2018Article
- First validation of myocardial flow reserve assessed by dynamicEuropean journal of nuclear medicine and molecular imaging · 2018Article
- Reporting myocardial flow reserve with PET. Ready or not, here it is! But walk before you fly!Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2018Article
- New Trends in Quantitative Nuclear Cardiology Methods.Current cardiovascular imaging reports · 2018Article
- Avoiding full corrections in dynamic SPECT images impacts the performance of SPECT myocardial blood flow quantitation.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2017Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeMyocardial blood flow (MBF) quantification with dynamic SPECT could lead to widespread utilization of MBF imaging in clinical practice with little cost increase over current standard SPECT myocardial perfusion imaging. This work evaluates the feasibility and operator-dependent variability of MBF and flow reserve measurements with (99m)Tc-sestamibi (MIBI) dynamic SPECT imaging using a standard dual-head SPECT camera.
methodsTwenty-eight patients underwent dipyridamole-stress and rest imaging with dynamic SPECT/CT acquisition. Quantitative images were iteratively reconstructed with all physical corrections and then myocardial and arterial blood regions of interest (ROI) were defined semi-automatically. A compartmental model was fitted to these ROI-sampled time-activity-curves, and flow-dependent MIBI extraction correction was applied to derive regional MBF values. Myocardial flow reserve (MFR) was estimated as stress/rest MBF ratio. MBF and MFR in low and high risk populations were evaluated for ability to detect disease. Images were each processed twice (≥7 days apart) by one expert and one novice operator to evaluate intra- and inter-operator variability of MBF and MFR measurement in the three coronary artery vascular territories.
resultsMean rest flow, stress flow, and MFR values were 0.83, 1.82 mL·minute(-1)·g(-1), and 2.45, respectively. For stress/rest MFR, the inter-operator reproducibility was r(2) = 0.86 with RPC = 1.1. Stress MBF and MFR were significantly reduced (P < .05) in high risk (n = 9) vs low risk populations (n = 19), indicating ability to detect disease. For expert and novice operators very good intra-operator correlations of r(2) = 0.98 and 0.95 (n = 168, P < .001) were observed for combined rest and stress regional flow values. Bland-Altman reproducibility coefficients (RPC) were 0.25 and 0.47 mL·minute(-1)·g(-1) for the expert and novice operators, respectively (P < .001). Inter-operator correlation was r(2) = 0.91 and Bland-Altman RPC = 0.58 mL·minute(-1)·g(-1) (n = 336).
conclusionsMBF and reserve measurements using (99m)Tc-sestamibi on a traditional, two-headed camera with fast rotation and with quantitative dynamic SPECT appears to be feasible, warranting further investigation.
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