ArticleMicrobiology (Reading, England)2014
Comparison of genes required for H2O2 resistance in Streptococcus gordonii and Streptococcus sanguinis.
Article in Microbiology (Reading, England), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 39 citations in OpenAlex.
- Unique Insights in the Cervicovaginal Lactobacillus iners and L. crispatus Proteomes and Their Associations with Microbiota Dysbiosis.PloS one · 2016Trial
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- The Quorum Sensing-Controlled Competence Regulon Drives HACS infectious diseases · 2025Article
- [Metabolic reprogramming by glutathione S-transferase enhances environmental adaptation ofHua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 2025Article
- Anti-cariogenic activity of mutanocyclin, a secondary metabolite ofMicrobiology spectrum · 2025Article
- Microbial interactions impact stress tolerance in a model oral community.Microbiology spectrum · 2024Article
- Experimental Inoculation ofInternational journal of molecular sciences · 2024Article
- Oxidative stress response: a critical factor affecting the ecological competitiveness ofJournal of oral microbiology · 2024Review
- Diversity of epiphytic bacterial communities on male and female Sargassum thunbergii.AMB Express · 2022Article
- Manganese transport by Streptococcus sanguinis in acidic conditions and its impact on growth in vitro and in vivo.Molecular microbiology · 2022Article
- A single system detects and protects the beneficial oral bacterium Streptococcus sp. A12 from a spectrum of antimicrobial peptides.Molecular microbiology · 2021Article
- Regulatory circuits controlling Spx levels in Streptococcus mutans.Molecular microbiology · 2020Article
- S-glutathionylation proteome profiling reveals a crucial role of a thioredoxin-like protein in interspecies competition and cariogenecity of Streptococcus mutans.PLoS pathogens · 2020Article
- Pyruvate secretion by oral streptococci modulates hydrogen peroxide dependent antagonism.The ISME journal · 2020Article
- Redox-Regulated Adaptation of Streptococcus oligofermentans to Hydrogen Peroxide Stress.mSystems · 2020Article
- Manganese Depletion Leads to Multisystem Changes in the Transcriptome of the Opportunistic PathogenFrontiers in microbiology · 2020Article
- The origin of exosomal miR-1246 in human cancer cells.RNA biology · 2019Article
- Where in the world do bacteria experience oxidative stress?Environmental microbiology · 2019Review
- Short-Time Antibacterial Effects of Dimethylaminododecyl Methacrylate on Oral Multispecies Biofilm In Vitro.BioMed research international · 2019Article
- Oxidoreductases and Reactive Oxygen Species in Conversion of Lignocellulosic Biomass.Microbiology and molecular biology reviews : MMBR · 2018Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
Hydrogen peroxide (H2O2) is produced by several members of the genus Streptococcus mainly through the pyruvate oxidase SpxB under aerobic growth conditions. The acute toxic nature of H2O2 raises the interesting question of how streptococci cope with intrinsically produced H2O2, which subsequently accumulates in the microenvironment and threatens the closely surrounding population. Here, we investigate the H2O2 susceptibility of oral Streptococcus gordonii and Streptococcus sanguinis and elucidate potential mechanisms of how they protect themselves from the deleterious effect of H2O2. Both organisms are considered primary colonizers and occupy the same intraoral niche making them potential targets for H2O2 produced by other species. We demonstrate that S. gordonii produces relatively more H2O2 and has a greater ability for resistance to H2O2 stress. Functional studies show that, unlike in Streptococcus pneumoniae, H2O2 resistance is not dependent on a functional SpxB and confirms the important role of the ferritin-like DNA-binding protein Dps. However, the observed increased H2O2 resistance of S. gordonii over S. sanguinis is likely to be caused by an oxidative stress protection machinery present even under anaerobic conditions, while S. sanguinis requires a longer period of time for adaptation. The ability to produce more H2O2 and be more resistant to H2O2 might aid S. gordonii in the competitive oral biofilm environment, since it is lower in abundance yet manages to survive quite efficiently in the oral biofilm.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.