ArticleClinical journal of the American Society of Nephrology : CJASN2014
Recognition and reporting of AKI in very low birth weight infants.
Article in Clinical journal of the American Society of Nephrology : CJASN, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05851222 (Predicting Acute Kidney Injury in Infants Exposed to Nephrotoxic Drugs), which is not on this map. Cited by 132 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Predicting Acute Kidney Injury in Infants Exposed to Nephrotoxic Drugs: A Big Data Approach to Predict NEOnatal Acute Kidney Injury in Newborns expoSed to nephroTOxic Drugs. (NeoAKI STOP)
Who cites it
132 citing papers in PubMed, 4 syntheses or guidelines pooled it, 251 citations in OpenAlex.
- Risk Factors for Nephrotoxicity Among Neonates Receiving Vancomycin: A Systematic Review and Meta-analysis.Paediatric drugs · 2025Pooled it
- Serum and urinary biomarkers to predict acute kidney injury in premature infants: a systematic review and meta-analysis of diagnostic accuracy.Journal of nephrology · 2022Pooled it
- Acute kidney injury in premature and low birth weight neonates: a systematic review and meta-analysis.Pediatric nephrology (Berlin, Germany) · 2022Pooled it
- The Japanese clinical practice guideline for acute kidney injury 2016.Clinical and experimental nephrology · 2018Guideline
- The Impact of Erythropoietin on Short- and Long-Term Kidney-Related Outcomes in Neonates of Extremely Low Gestational Age. Results of a Multicenter, Double-Blind, Placebo-Controlled Randomized Clinical Trial.The Journal of pediatrics · 2021Trial
- Prevalence of acute kidney injury (AKI) in extremely low gestational age neonates (ELGAN).Pediatric nephrology (Berlin, Germany) · 2020Trial
- Proteomic identification of early urinary-biomarkers of acute kidney injury in preterm infants.Scientific reports · 2020Trial
- From survival to surveillance: the long-term kidney legacy of preterm birth.Pediatric nephrology (Berlin, Germany) · 2026Article
- Validation of STARZ scoring in very low birth weight (VLBW) neonates in the United States.Pediatric research · 2026Article
- Kidney health and blood pressure after very preterm birth: a cohort study at school age.Pediatric nephrology (Berlin, Germany) · 2026Article
- Comparison of creatinine- and cystatin C-based definitions of acute kidney injury in neonates with congenital diaphragmatic hernia.Pediatric nephrology (Berlin, Germany) · 2026Observational
- High early fluid and sodium intake as risk factors for acute kidney injury in very-low-birthweight infants.Pediatric nephrology (Berlin, Germany) · 2026Article
- Renal resistive index and neonatal sequential organ failure assessment score as acute kidney injury risk predictors in preterm neonates with late-onset neonatal sepsis.Frontiers in nephrology · 2026Article
- Development and validation of a nomogram for predicting neonatal acute kidney injury in very low birth weight infants.Maternal health, neonatology and perinatology · 2025Article
- Evaluation of acute kidney injury in preterm infants using serum creatinine decline in comparison with KDIGO criteria.Pediatric nephrology (Berlin, Germany) · 2025Article
- Neonatal acute kidney injury and neurodevelopmental impairment: investigating associations in very low birthweight infants.Journal of perinatology : official journal of the California Perinatal Association · 2025Article
- Continuous renal replacement therapy in extremely low birth weight infants: a series of 5 cases.Italian journal of pediatrics · 2025Article
- The incidence of acute kidney injury in very-low-birth-weight infants treated early with caffeine.Pediatric nephrology (Berlin, Germany) · 2025Article
- Neonatal Kidney Function, Injury and Drug Dosing: A Contemporary Review.Children (Basel, Switzerland) · 2025Review
- Evaluation of uNGAL and TIMP-2*IGFBP7 as early biomarkers of Acute Kidney Injury in Caucasian term and preterm neonates: a prospective observational cohort study.Italian journal of pediatrics · 2025Observational
72 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
BACKGROUND AND
objectivesAKI is associated with both increased short-term morbidity and mortality and greater long-term risk for CKD. This study determined the prevalence of AKI among very low birth weight infants using a modern study definition, evaluated the frequency of AKI diagnosis reporting in the discharge summary, and determined whether infants were referred to a pediatric nephrologist for AKI follow-up. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Records of very low birth weight infants admitted to a level IV neonatal intensive care unit from 2008 to 2011 were reviewed. AKI was classified using the Kidney Disease: Improving Global Outcomes definition modified to include only serum creatinine.
resultsAKI occurred in 39.8% of 455 infants; 75 (16.5%) infants experienced multiple episodes of AKI, and 8 (2%) infants were discharged with an abnormal last creatinine. Updated clinical risk index for babies score >10 (odds ratio, 12.9; 95% confidence interval, 7.8 to 21.4) and gestational age <28 weeks (odds ratio, 10.6; 95% confidence interval, 6.8 to 16.7) were strongly associated with AKI in univariate analyses. AKI was associated with increased mortality (odds ratio, 4.0; 95% confidence interval, 1.4 to 11.5) and length of stay (11.7 hospital days; 95% confidence interval, 5.1 to 18.4), even after accounting for gestational age, birth weight, and updated clinical risk index for babies score. AKI was recorded in the discharge summary for only 13.5% of AKI survivors. No infants were referred to a nephrologist for AKI follow-up.
conclusionsAKI occurred in 40% of very low birth weight infants and was concentrated in the most premature and severely ill infants. One in six infants experienced multiple episodes of AKI, and a small number of infants was discharged with an elevated serum creatinine. Reporting a history of AKI in the discharge summary occurred infrequently, and referral to a nephrologist for AKI follow-up did not occur, highlighting areas for quality improvement.
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