Evidence map›Paper›PMID 25280484›Full record

ArticleBMC neurology2014

The GC + CC genotype at position -418 in TIMP-2 promoter and the -1575GA/-1306CC genotype in MMP-2 is genetic predisposing factors for prevalence of moyamoya disease.

Young Seok Park, Young Joo Jeon, Hyun Seok Kim, In Bo Han, Seung-Hun Oh, Dong-Seok Kim, Nam Keun Kim

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC neurology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04463290 (Association of Single Nucleotide Polymorphisms), which is not on this map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04463290 unknown statusnot on this mapstarted 2020, after this paper: background citation

Association of Single Nucleotide Polymorphisms (SNPs) in Metalloproteinases (MMPs) Genes With the Risk of Primary Knee Osteoarthritis in Greek Population.

TypeobservationalSponsorAristotle University Of ThessalonikiRan2020 to 2022Enrolled200ConditionsMetalloproteinase SNPs -1575 G/A MMP-2, 836 A/G MMP-9 and -77 A/G MMP-13 and Risk for Developing Knee Osteoarthritis in Greek PopulationArmsNo intervention, Patients selection based on clinical symptoms and radiological imaging
3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
  2. Article
  3. The Genetic Basis of Moyamoya Disease.Translational stroke research · 2022
    Review
  4. Article
  5. Article
  6. Single Nucleotide Polymorphism in Patients with Moyamoya Disease.Journal of Korean Neurosurgical Society · 2015
    Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Young Seok Park
Young Joo Jeon
Hyun Seok Kim
In Bo Han
Seung-Hun Oh
Dong-Seok KimInstitute for Clinical Research, CHA University School of Medicine, Seongnam, South Korea. dskim33@yuhs.ac.
Nam Keun Kim
CHA University · KRCHA University Bundang Medical Center · KRChungbuk National University · KRSeverance Hospital · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTo investigate the association of single-nucleotide polymorphisms (SNPs) in matrix metalloproteinases (MMPs)-2, -3, and -9 and tissue inhibitor of metalloproteinase (TIMP)-2 with moyamoya disease (MMD). We conducted a case-control study of MMD patients by assessing the prevalence of six SNPs of MMP-2 -1575G > A [rs243866], MMP-2 -1306C > T [rs243865], MMP-3 -1171 5a/6a [rs3025058], MMP-9 -1562C > T [rs3918242], MMP-9 Q279R [rs17576], and TIMP-2 -418G > C [rs8179090].

methodsKorean patients with MMD (n = 107, mean age, 20.9 ± 15.9 years; 66.4% female) and 243 healthy control subjects (mean age, 23.0 ± 16.1 years; 56.8% female) were included. The subjects were divided into pediatric and adult groups. The genotyping of six well-known SNPs (MMP-2 -1575G > A, MMP-2 -1306C > T, MMP-3 -1171 5a/6a, MMP-9 -1562C > T, MMP-9 Q279R, and TIMP-2 -418G > C) in MMP and TIMP genes was performed by polymerase chain reaction-restriction fragment length polymorphism assays.

resultsA significantly higher frequency of the GC genotype for TIMP-2 -418 G > C was found in MMD patients. The MMP-9 Q279R GA + AA genotype showed a protective effect for MMD. The GA/CC MMP-2 -1575/-1306 genotype was significantly more prevalent in MMD patients.

conclusionsOur findings demonstrate that TIMP-2 -418 GC + CC and MMP-2 -1575GA/-1306CC genotypes could be genetic predisposing factors for MMD development.

Indexed as

AdolescentAdultCase-Control StudiesChildFemaleGenetic Predisposition to DiseaseGenotypeHumansMaleMatrix Metalloproteinase 2Moyamoya DiseasePolymorphism, Single NucleotidePrevalencePromoter Regions, GeneticRepublic of KoreaTissue Inhibitor of Metalloproteinase-2Matrix Metalloproteinase 2Tissue Inhibitor of Metalloproteinase-2

Identifiers

PMID25280484
PMCPMC4196131
OpenAlexW2147596030

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.