ArticlePloS one2014
Sequence and annotation of the apicoplast genome of the human pathogen Babesia microti.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 43 citations in OpenAlex.
- Modes and mechanisms for the inheritance of mitochondria and plastids in pathogenic protists.PLoS pathogens · 2025Review
- tRNA lysidinylation is essential for the minimal translation system found in the apicoplast ofbioRxiv : the preprint server for biology · 2024Article
- Transfection ofBio-protocol · 2024Article
- Effectiveness of Two New Endochin-like Quinolones, ELQ-596 and ELQ-650, in Experimental Mouse Models of Human Babesiosis.ACS infectious diseases · 2024Article
- Apicoplast-Resident Processes: Exploiting the Chink in the Armour ofAdvances in pharmacological and pharmaceutical sciences · 2024Review
- Transfusion-transmittedJournal of clinical microbiology · 2023Review
- Article
- New insights into apicoplast metabolism in blood-stage malaria parasites.Current opinion in microbiology · 2023Review
- Plasmodium-a brief introduction to the parasites causing human malaria and their basic biology.Journal of physiological anthropology · 2021Review
- Annotation and characterization of Babesia gibsoni apicoplast genome.Parasites & vectors · 2020Article
- There Is Treasure Everywhere: Reductive Plastid Evolution in Apicomplexa in Light of Their Close Relatives.Biomolecules · 2019Review
- Comparative analysis of apicoplast genomes of Babesia infective to small ruminants in China.Parasites & vectors · 2019Article
- Evidence for vesicle-mediated antigen export by the human pathogenLife science alliance · 2019Article
- Insights into the evolution and drug susceptibility of Babesia duncani from the sequence of its mitochondrial and apicoplast genomes.International journal for parasitology · 2019Article
- Case report of the patient source of the Babesia microti R1 reference strain and implications for travelers.Journal of travel medicine · 2018Article
- Clinical and Molecular Evidence of Atovaquone and Azithromycin Resistance in Relapsed Babesia microti Infection Associated With Rituximab and Chronic Lymphocytic Leukemia.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2017Article
- Comparative sequence analysis of Cyclospora cayetanensis apicoplast genomes originating from diverse geographical regions.Parasites & vectors · 2016Article
- Babesia microti from humans and ticks hold a genomic signature of strong population structure in the United States.BMC genomics · 2016Article
- A method for identification of highly conserved elements and evolutionary analysis of superphylum Alveolata.BMC bioinformatics · 2016Article
- Regulation of Expression and Evolution of Genes in Plastids of Rhodophytic Branch.Life (Basel, Switzerland) · 2016Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
The apicomplexan intraerythrocytic parasite Babesia microti is an emerging human pathogen and the primary cause of human babesiosis, a malaria-like illness endemic in the United States. The pathogen is transmitted to humans by the tick vector, Ixodes scapularis, and by transfusion of blood from asymptomatic B. microti-infected donors. Whereas the nuclear and mitochondrial genomes of this parasite have been sequenced, assembled and annotated, its apicoplast genome remained incomplete, mainly due to its low representation and high A+T content. Here we report the complete sequence and annotation of the apicoplast genome of the B. microti R1 isolate. The genome consists of a 28.7 kb circular molecule encoding primarily functions important for maintenance of the apicoplast DNA, transcription, translation and maturation of organellar proteins. Genome analysis and annotation revealed a unique gene structure and organization of the B. microti apicoplast genome and suggest that all metabolic and non-housekeeping functions in this organelle are nuclear-encoded. B. microti apicoplast functions are significantly different from those of the host, suggesting that they might be useful as targets for development of potent and safe therapies for the treatment of human babesiosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.