Evidence map›Paper›PMID 25279987›Full record

ArticlePediatric research2015

Respiratory inductance plethysmography calibration for pediatric upper airway obstruction: an animal model.

Robinder G Khemani, Rutger Flink, Justin Hotz, Patrick A Ross, Anoopindar Ghuman, Christopher J L Newth

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Article in Pediatric research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Robinder G Khemani1] Department of Anesthesiology and Critical Care Medicine, Children's Hospital Los Angeles, Los Angeles, California [2] Department of Pediatrics, University of Southern California Keck School of Medicine, Los Angeles, California.
Rutger Flink1] Department of Anesthesiology and Critical Care Medicine, Children's Hospital Los Angeles, Los Angeles, California [2] Department of Biomedical Engineering, University of Groningen, Groningen, The Netherlands.
Justin HotzDepartment of Anesthesiology and Critical Care Medicine, Children's Hospital Los Angeles, Los Angeles, California.
Patrick A Ross1] Department of Anesthesiology and Critical Care Medicine, Children's Hospital Los Angeles, Los Angeles, California [2] Department of Pediatrics, University of Southern California Keck School of Medicine, Los Angeles, California.
Anoopindar Ghuman1] Department of Anesthesiology and Critical Care Medicine, Children's Hospital Los Angeles, Los Angeles, California [2] Department of Pediatrics, University of Southern California Keck School of Medicine, Los Angeles, California.
Christopher J L Newth1] Department of Anesthesiology and Critical Care Medicine, Children's Hospital Los Angeles, Los Angeles, California [2] Department of Pediatrics, University of Southern California Keck School of Medicine, Los Angeles, California.

Funding

Minimally invasive techniques to measure upper airway obstruction in childrenK23HD075069 · NICHD · CHILDREN'S HOSPITAL OF LOS ANGELES · PI KHEMANI, ROBINDER · 2012 to 2016
$668k
Regulation of ENaC in salt-sensitive hypertension via inflammation-induced ROS prK99HL116603 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI PAVLOV, TENGIS S · 2013 to 2014
$180k
NHLBI NIH HHS K99 HL116603NICHD NIH HHS K23 HD075069
6 · The paper itself

Abstract

backgroundWe sought to determine optimal methods of respiratory inductance plethysmography (RIP) flow calibration for application to pediatric postextubation upper airway obstruction.

methodsWe measured RIP, spirometry, and esophageal manometry in spontaneously breathing, intubated Rhesus monkeys with increasing inspiratory resistance. RIP calibration was based on: ΔµV(ao) ≈ M[ΔµV(RC) + K(ΔµV(AB))] where K establishes the relationship between the uncalibrated rib cage (ΔµV(RC)) and abdominal (ΔµV(AB)) RIP signals. We calculated K during (i) isovolume maneuvers during a negative inspiratory force (NIF), (ii) quantitative diagnostic calibration (QDC) during (a) tidal breathing, (b) continuous positive airway pressure (CPAP), and (c) increasing degrees of upper airway obstruction (UAO). We compared the calibrated RIP flow waveform to spirometry quantitatively and qualitatively.

resultsIsovolume calibrated RIP flow tracings were more accurate (against spirometry) both quantitatively and qualitatively than those from QDC (P < 0.0001), with bigger differences as UAO worsened. Isovolume calibration yielded nearly identical clinical interpretation of inspiratory flow limitation as spirometry.

conclusionIn an animal model of pediatric UAO, isovolume calibrated RIP flow tracings are accurate against spirometry. QDC during tidal breathing yields poor RIP flow calibration, particularly as UAO worsens. Routine use of a NIF maneuver before extubation affords the opportunity to use RIP to study postextubation UAO in children.

Indexed as

Airway ObstructionAnimalsCalibrationDisease Models, AnimalEsophagusHumansMacaca mulattaManometryPlethysmographyReproducibility of ResultsRespirationSpirometryTidal Volume

Identifiers

PMID25279987
PMCPMC4268304

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.