Evidence map›Paper›PMID 25279779›Full record

ArticleOptometry and vision science : official publication of the American Academy of Optometry2014

Assessment of corneal epithelial thickness in dry eye patients.

Xinhan Cui, Jiaxu Hong, Fei Wang, Sophie X Deng, Yujing Yang, Xiaoyu Zhu, Dan Wu, Yujin Zhao, Jianjiang Xu

Abstract read
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Article in Optometry and vision science : official publication of the American Academy of Optometry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.

0numbers the graph read from it
0cells of the map it votes in
62citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

62 citing papers in PubMed.

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  5. The relationship between correction modality and clinical signs and symptoms of dry eye and meibomian gland dysfunction in keratoconic patients.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2026
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2 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Xinhan Cui*MD †MD, PhD Department of Ophthalmology, Eye, Ear, Nose, and Throat Hospital, School of Shanghai Medicine, Fudan University, Shanghai, China (XC, JH, FW, YY, DW, YZ, JX); School of Life Sciences, Xiamen University, Fujian Provincial Key Laboratory of Ophthalmology and Visual Science, Xiamen, China (JH); State Key Laboratory of Medical Neurobiology, Institutes of Brain Science, Shanghai, China (JH); Health Communication Institute, Fudan University, Shanghai, China (JH); Department of Ophthalmology, the Jules Stein Eye Institute, University of California, Los Angeles, California (SXD); and Department of Ophthalmology, Jinshan Hospital, School of Shanghai Medicine, Fudan University, Shanghai, China (XZ).
Jiaxu Hong
Fei Wang
Sophie X Deng
Yujing Yang
Xiaoyu Zhu
Dan Wu
Yujin Zhao
Jianjiang Xu

Funding

Vision Science Training ProgramT32EY007026 · NEI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Alapakkam P Sampath · 1985 to 2026
$5.7M
Ex Vivo Expansion of Human Limbal Stem Cells for TransplantationR01EY021797 · NEI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Sophie Deng · 2012 to 2026
$5.1M
NEI NIH HHS 2T3EY007026NEI NIH HHS R01 EY021797NEI NIH HHS R01EY021797NEI NIH HHS T32 EY007026
6 · The paper itself

Abstract

purposeTo investigate the features of corneal epithelial thickness topography with Fourier-domain optical coherence tomography (OCT) in dry eye patients.

methodsIn this cross-sectional study, 100 symptomatic dry eye patients and 35 normal subjects were enrolled. All participants answered the ocular surface disease index questionnaire and were subjected to OCT, corneal fluorescein staining, tear breakup time, Schirmer 1 test without anesthetic (S1t), and meibomian morphology. Several epithelium statistics for each eye, including central, superior, inferior, minimum, maximum, minimum - maximum, and map standard deviation, were averaged. Correlations of epithelial thickness with the symptoms of dry eye were calculated.

resultsThe mean (±SD) central, superior, and inferior corneal epithelial thickness was 53.57 (±3.31) μm, 52.00 (±3.39) μm, and 53.03 (±3.67) μm in normal eyes and 52.71 (±2.83) μm, 50.58 (±3.44) μm, and 52.53 (±3.36) μm in dry eyes, respectively. The superior corneal epithelium was thinner in dry eye patients compared with normal subjects (p = 0.037), whereas central and inferior epithelium were not statistically different. In the dry eye group, patients with higher severity grades had thinner superior (p = 0.017) and minimum (p < 0.001) epithelial thickness, more wide range (p = 0.032), and greater deviation (p = 0.003). The average central epithelial thickness had no correlation with tear breakup time, S1t, or the severity of meibomian glands, whereas average superior epithelial thickness positively correlated with S1t (r = 0.238, p = 0.017).

conclusionsFourier-domain OCT demonstrated that the thickness map of the dry eye corneal epithelium was thinner than normal eyes in the superior region. In more severe dry eye disease patients, the superior and minimum epithelium was much thinner, with a greater range of map standard deviation.

Indexed as

AdolescentAdultAgedAged, 80 and overCorneal PachymetryCross-Sectional StudiesDry Eye SyndromesEpithelium, CornealFemaleFourier AnalysisHumansMaleMiddle AgedOrgan SizeSurveys and QuestionnairesTears

Identifiers

PMID25279779
PMCPMC4302058

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.