ArticlePloS one2014
Bone suppression increases the visibility of invasive pulmonary aspergillosis in chest radiographs.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 15 citations in OpenAlex.
- Limited Diagnostic and Therapeutic Value of Chest X-Rays in Hematological Patients With Febrile Neutropenia.Open forum infectious diseases · 2025Article
- Artificial Intelligence-Based Software with CE Mark for Chest X-ray Interpretation: Opportunities and Challenges.Diagnostics (Basel, Switzerland) · 2023Review
- Review on chest pathogies detection systems using deep learning techniques.Artificial intelligence review · 2023Article
- Improved detection of solitary pulmonary nodules on radiographs compared with deep bone suppression imaging.Quantitative imaging in medicine and surgery · 2021Article
- Chest X-ray Bone Suppression for Improving Classification of Tuberculosis-Consistent Findings.Diagnostics (Basel, Switzerland) · 2021Article
- Invasive pulmonary aspergillosis: current diagnostic methodologies and a new molecular approach.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2018Review
- Computer-aided Detection Fidelity of Pulmonary Nodules in Chest Radiograph.Journal of clinical imaging science · 2017Article
- A novel bone suppression method that improves lung nodule detection : Suppressing dedicated bone shadows in radiographs while preserving the remaining signal.International journal of computer assisted radiology and surgery · 2016Article
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Authors and funding
11 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveChest radiographs (CXR) are an important diagnostic tool for the detection of invasive pulmonary aspergillosis (IPA) in critically ill patients, but their diagnostic value is limited by a poor sensitivity. By using advanced image processing, the aim of this study was to increase the value of chest radiographs in the diagnostic work up of neutropenic patients who are suspected of IPA.
methodsThe frontal CXRs of 105 suspected cases of IPA were collected from four institutions. Radiographs could contain single or multiple sites of infection. CT was used as reference standard. Five radiologists and two residents participated in an observer study for the detection of IPA on CXRs with and without bone suppressed images (ClearRead BSI 3.2; Riverain Technologies). The evaluation was performed separately for the right and left lung, resulting in 78 diseased cases (or lungs) and 132 normal cases (or lungs). For each image, observers scored the likelihood of focal infectious lesions being present on a continuous scale (0-100). The area under the receiver operating characteristics curve (AUC) served as the performance measure. Sensitivity and specificity were calculated by considering only the lungs with a suspiciousness score of greater than 50 to be positive.
resultsThe average AUC for only CXRs was 0.815. Performance significantly increased, to 0.853, when evaluation was aided with BSI (p = 0.01). Sensitivity increased from 49% to 66% with BSI, while specificity decreased from 95% to 90%.
conclusionThe detection of IPA in CXRs can be improved when their evaluation is aided by bone suppressed images. BSI improved the sensitivity of the CXR examination, outweighing a small loss in specificity.
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