ArticlePloS one2014
Releasing dentate nucleus cells from Purkinje cell inhibition generates output from the cerebrocerebellum.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 2 of them syntheses that pooled it.
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Who cites it
50 citing papers in PubMed, 2 syntheses or guidelines pooled it, 85 citations in OpenAlex.
- Pathophysiology of Cerebellar Tremor: The Forward Model-Related Tremor and the Inferior Olive Oscillation-Related Tremor.Frontiers in neurology · 2021Pooled it
- Cerebral Cortical Activity Following Non-invasive Cerebellar Stimulation-a Systematic Review of Combined TMS and EEG Studies.Cerebellum (London, England) · 2020Pooled it
- Compensatory and Dynamic Cerebellar Responses to Striatal Lesions in Experimental Parkinsonism.Cerebellum (London, England) · 2026Article
- A neural language for the cerebellum: control of behavior via competing populations of Purkinje cells.Journal of neurophysiology · 2026Review
- Consensus Paper: Models of Cerebellar Functions.Cerebellum (London, England) · 2026Review
- Comparison of Signals from Cerebellar Purkinje Cells and Deep Nuclei during Temporal Prediction in Primates.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Purkinje cells of the cerebellum control deceleration of tongue movements.PLoS biology · 2025Article
- Article
- Control of tongue movements by the Purkinje cells of the cerebellum.bioRxiv : the preprint server for biology · 2025Article
- Ablation of Projection Glutamatergic Neurons in the Lateral Cerebellar Nuclei Alters Motor Coordination in Vglut2-Cre+ Mice.Cerebellum (London, England) · 2024Article
- The olivary input to the cerebellum dissociates sensory events from movement plans.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Advances in the Pathogenesis of Auto-antibody-Induced Cerebellar Synaptopathies.Cerebellum (London, England) · 2023Review
- An update on malignant tumor-related stiff person syndrome spectrum disorders: clinical mechanism, treatment, and outcomes.Frontiers in neurology · 2023Review
- Effect of Low Frequency Cerebellar Repetitive Transcranial Magnetic Stimulation on Balance Impairment in Patients With Cerebral Infarction.Annals of rehabilitation medicine · 2022Article
- Synchronous spiking of cerebellar Purkinje cells during control of movements.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Portable Neuroimaging-Guided Noninvasive Brain Stimulation of the Cortico-Cerebello-Thalamo-Cortical Loop-Hypothesis and Theory in Cannabis Use Disorder.Brain sciences · 2022Article
- Cerebellar transcranial direct current stimulation disrupts neuroplasticity of intracortical motor circuits.PloS one · 2022Article
- Cerebro-cerebellar interactions in nonhuman primates examined by optogenetic functional magnetic resonance imaging.Cerebral cortex communications · 2022Article
- Baseline Cerebro-Cerebellar Functional Connectivity in Afferent and Efferent Pathways Reveal Dissociable Improvements in Visuomotor Learning.Frontiers in neuroscience · 2022Article
- Purkinje Cell Activity in the Medial and Lateral Cerebellum During Suppression of Voluntary Eye Movements in Rhesus Macaques.Frontiers in cellular neuroscience · 2022Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The cerebellum generates its vast amount of output to the cerebral cortex through the dentate nucleus (DN) that is essential for precise limb movements in primates. Nuclear cells in DN generate burst activity prior to limb movement, and inactivation of DN results in cerebellar ataxia. The question is how DN cells become active under intensive inhibitory drive from Purkinje cells (PCs). There are two excitatory inputs to DN, mossy fiber and climbing fiber collaterals, but neither of them appears to have sufficient strength for generation of burst activity in DN. Therefore, we can assume two possible mechanisms: post-inhibitory rebound excitation and disinhibition. If rebound excitation works, phasic excitation of PCs and a concomitant inhibition of DN cells should precede the excitation of DN cells. On the other hand, if disinhibition plays a primary role, phasic suppression of PCs and activation of DN cells should be observed at the same timing. To examine these two hypotheses, we compared the activity patterns of PCs in the cerebrocerebellum and DN cells during step-tracking wrist movements in three Japanese monkeys. As a result, we found that the majority of wrist-movement-related PCs were suppressed prior to movement onset and the majority of wrist-movement-related DN cells showed concurrent burst activity without prior suppression. In a minority of PCs and DN cells, movement-related increases and decreases in activity, respectively, developed later. These activity patterns suggest that the initial burst activity in DN cells is generated by reduced inhibition from PCs, i.e., by disinhibition. Our results indicate that suppression of PCs, which has been considered secondary to facilitation, plays the primary role in generating outputs from DN. Our findings provide a new perspective on the mechanisms used by PCs to influence limb motor control and on the plastic changes that underlie motor learning in the cerebrocerebellum.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.