Evidence map›Paper›PMID 25279731›Full record

ArticlePloS one2014

Peripheral blood mitochondrial DNA copy number is associated with prostate cancer risk and tumor burden.

Weimin Zhou, Min Zhu, Ming Gui, Lihua Huang, Zhi Long, Li Wang, Hui Chen, Yinghao Yin, Xianzhen Jiang, Yingbo Dai and 3 more

Open access · goldAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 1 pooled it
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 1 synthesis or guideline pooled it, 62 citations in OpenAlex.

  1. Pooled it
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  11. Extrachromosomal Circular DNA (eccDNA): From Chaos to Function.Frontiers in cell and developmental biology · 2021
    Review
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  14. Cancer epithelia-derived mitochondrial DNA is a targetable initiator of a paracrine signaling loop that confers taxane resistance.Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  15. Mitochondrial DNA Copy-Number Variation and Pancreatic Cancer Risk in the Prospective EPIC Cohort.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2020
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Weimin ZhouDepartment of Urology, The Third Xiangya Hospital, Central South University, Changsha, China; Department of Abdominal Surgery, Jiangxi Cancer Hospital, Nanchang, China.
Min ZhuMolecular Biology Research Center, Xiangya School of Medicine, Central South University, Changsha, China.
Ming GuiDepartment of Nephrology, The Third Xiangya Hospital, Central South University, Changsha, China.
Lihua HuangCenter for Medical Experiments, The Third Xiangya Hospital, Central South University, Changsha, China.
Zhi LongDepartment of Urology, The Third Xiangya Hospital, Central South University, Changsha, China.
Li WangDepartment of Nephrology, The Third Xiangya Hospital, Central South University, Changsha, China.
Hui ChenDepartment of Epidemiology and Statistics, Public Health School, Central South University, Changsha, China.
Yinghao YinDepartment of Urology, The Third Xiangya Hospital, Central South University, Changsha, China.
Xianzhen JiangDepartment of Urology, The Third Xiangya Hospital, Central South University, Changsha, China.
Yingbo DaiDepartment of Urology, The Third Xiangya Hospital, Central South University, Changsha, China.
Yuxin TangDepartment of Urology, The Third Xiangya Hospital, Central South University, Changsha, China.
Leye HeDepartment of Urology, The Third Xiangya Hospital, Central South University, Changsha, China.
Kuangbiao ZhongDepartment of Urology, The Third Xiangya Hospital, Central South University, Changsha, China.
Central South University · CNThird Xiangya Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alterations of mitochondrial DNA (mtDNA) have been associated with the risk of a number of human cancers; however, the relationship between mtDNA copy number in peripheral blood leukocytes (PBLs) and the risk of prostate cancer (PCa) has not been investigated. In a case-control study of 196 PCa patients and 196 age-paired healthy controls in a Chinese Han population, the association between mtDNA copy number in PBLs and PCa risk was evaluated. The relative mtDNA copy number was measured using quantitative real-time PCR; samples from three cases and two controls could not be assayed, leaving 193 cases and 194 controls for analysis. PCa patients had significantly higher mtDNA copy numbers than controls (medians 0.91 and 0.82, respectively; P<0.001). Dichotomized at the median value of mtDNA copy number in the controls, high mtDNA copy number was significantly associated with an increased risk of PCa (adjusted odds ratio= 1.85, 95% confidence interval: 1.21-2.83). A significant dose-response relationship was observed between mtDNA copy number and risk of PCa in quartile analysis (Ptrend = 0.011). Clinicopathological analysis showed that high mtDNA copy numbers in PCa patients were significantly associated with high Gleason score and advanced tumor stage, but not serum prostate-specific antigen level (P = 0.002, 0.012 and 0.544, respectively). These findings of the present study indicate that increased mtDNA copy number in PBLs is significantly associated with an increased risk of PCa and may be a reflection of tumor burden.

Indexed as

AdenocarcinomaAgedCase-Control StudiesDNA Copy Number VariationsDNA, MitochondrialFollow-Up StudiesHumansLeukocytesMaleMitochondriaNeoplasm GradingNeoplasm StagingPrognosisProstatic NeoplasmsReal-Time Polymerase Chain ReactionRetrospective StudiesDNA, Mitochondrial

Identifiers

PMID25279731
PMCPMC4184876
OpenAlexW2060242635

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.