ArticlePloS one2014
Reduced right frontal fractional anisotropy correlated with early elevated plasma LDL levels in obese young adults.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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15 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- Neuroimaging Investigations of Obesity: a Review of the Treatment of Sex from 2010.Current obesity reports · 2023Pooled it
- Longstanding smoking associated with frontal brain lobe atrophy: a 32-year follow-up study in women.BMJ open · 2023Article
- Beyond BMI: cardiometabolic measures as predictors of impulsivity and white matter changes in adolescents.Brain structure & function · 2023Article
- Basal ganglia lesions may be a risk factor for characteristic features of a glaucomatous optic disc: population-based cohort study in Japan.BMJ open ophthalmology · 2023Article
- Extended and replicated white matter changes in obesity: Voxel-based and region of interest meta-analyses of diffusion tensor imaging studies.Frontiers in nutrition · 2023Article
- Obesity and Gray Matter Volume Assessed by Neuroimaging: A Systematic Review.Brain sciences · 2021Review
- Pain in the Developing Brain: Early Life Factors Alter Nociception and Neurobiological Function in Adolescent Rats.Cerebral cortex communications · 2021Article
- Article
- Non-fasting High-Density Lipoprotein Is Associated With White Matter Microstructure in Healthy Older Adults.Frontiers in aging neuroscience · 2019Article
- Neuroinflammation and White Matter Alterations in Obesity Assessed by Diffusion Basis Spectrum Imaging.Frontiers in human neuroscience · 2019Article
- White matter microstructure and cognitive decline in metabolic syndrome: a review of diffusion tensor imaging.Metabolism: clinical and experimental · 2018Review
- Midlife and Late-Life Vascular Risk Factors and White Matter Microstructural Integrity: The Atherosclerosis Risk in Communities Neurocognitive Study.Journal of the American Heart Association · 2017Article
- Microstructural abnormalities in white and gray matter in obese adolescents with and without type 2 diabetes.NeuroImage. Clinical · 2017Article
- Altered Regional Gray Matter Volume in Obese Men: A Structural MRI Study.Frontiers in psychology · 2017Article
- Higher Adolescent Body Mass Index Is Associated with Lower Regional Gray and White Matter Volumes and Lower Levels of Positive Emotionality.Frontiers in neuroscience · 2016Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo investigate the underlying physiological mechanisms of the structural differences in gray matter (GM) and white matter (WM) associated with obesity in young Chinese adults. MATERIALS AND
methodsA total of 49 right-handed obese or overweight (n = 22, mean age 31.72±8.04 years) and normal weight (n = 27, mean age 29.04±7.32 years) Han Chinese individuals were recruited. All participants underwent voxel-based morphometry analysis of T1-weighted MRI and tract-based spatial statistics analysis of diffusion tensor imaging. Partial correlation analysis was performed between the physiological data obtained and the abnormal structural alterations.
resultsIn the OO group, GM atrophy occurred in the left prefrontal cortex, bilateral cingulate gyrus, and the right temporal lobe, while enlargement was observed in the bilateral putamen. WM atrophy was observed predominantly in the regions that regulate food intake, such as the bilateral basal ganglia, the right amygdala, and the left insula. The OO group exhibited lower fractional anisotropy (FA) in bilateral frontal corticospinal tracts and the right brainstem. Significant negative correlations were observed between FA values of those three clusters and BMI, and waist circumference, while the volume of bilateral putamen positively correlated with both BMI and waist circumference. High plasma LDL levels were correlated with low FA values in the right frontal corticospinal tract. Interestingly, the negative correlation was limited to male participants.
conclusionsObesity-related alterations of GM and WM volumes were observed predominantly in food reward circuit, which may motivate abnormal dietary intake. Further, early elevated plasma LDL might contribute to low right frontal FA values of male adults, which requires further demonstration by larger-scale and longitudinal studies.
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