Trial reportPloS one2014
Dental prophylaxis decreases the risk of esophageal cancer in males; a nationwide population-based study in Taiwan.
Trial report in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.
- Potential risk of certain cancers among patients with Periodontitis: a supplementary meta-analysis of a large-scale population.International journal of medical sciences · 2020Pooled it
- The oral - X axis: from periodontal dysbiosis to systemic disease.Frontiers in immunology · 2026Review
- Impact of public health and patient-centered prevention strategies on periodontitis and caries as causes of tooth loss in high-income countries.Periodontology 2000 · 2025Review
- Causal association between periodontitis and oral cancer: a two-sample Mendelian randomization study.Discover oncology · 2025Article
- Association between periodontitis and gastrointestinal cancer risk and prognosis: evidence from a nested case-control study in Southwest China.European journal of medical research · 2025Article
- Relationship between periodontitis and systemic health conditions: a narrative review.Ewha medical journal · 2025Review
- The relationship between preventive dental care and overall medical expenditures.The American journal of managed care · 2024Article
- The analysis of periodontal diseases and squamous cell esophageal cancer: A retrospective study.The Saudi dental journal · 2023Article
- The relationship betweenEpidemiology and infection · 2023Review
- Use of the dental formula from the National Database of Health Insurance Claims and Specific Health Checkups of Japan.The Japanese dental science review · 2022Review
- Microbiome and Cancers of the Esophagus: A Review.Microorganisms · 2021Review
- Association between infection with Campylobacter species, poor oral health and environmental risk factors on esophageal cancer: a hospital-based case-control study in Thailand.European journal of medical research · 2021Article
- Human Microbiota in Esophageal Adenocarcinoma: Pathogenesis, Diagnosis, Prognosis and Therapeutic Implications.Frontiers in microbiology · 2021Review
- Periodontal disease and cancer: Epidemiologic studies and possible mechanisms.Periodontology 2000 · 2020Review
- The potential role ofInfectious agents and cancer · 2019Review
- Risk of lung cancer in patients with gastro-esophageal reflux disease: a population-based cohort study.PeerJ · 2016Article
- Association between tooth loss and risk of oesophageal cancer: a dose-response meta-analysis.SpringerPlus · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPeriodontal disease (PD) is one of the most common chronic inflammatory diseases. Esophageal cancer (EC) is also a common cause of death due to cancer among males. Systemic inflammatory processes have been shown to increase the risk of cancer. We conducted a retrospective cohort study to investigate the association between PD and EC.
methodsA total of 718,409 subjects were recruited from the Taiwan National Health Insurance Research Database (NHIRD) and followed from January 1, 2000 to December 31, 2010. Of these, 519,831 subjects were diagnosed with PD and were grouped according to the most advanced treatment they received: dental prophylaxis, intensive treatment, or no treatment. The IRs of EC were compared among groups.
resultsA total of 682 patients developed EC, resulting in an overall IR of 0.11 case-number per 1000 person-years (‰/y). The dental prophylaxis group had a significantly lower IR of EC (0.06‰/y) than other groups (p<0.001). Multivariable Cox regression analysis further revealed that male subjects [hazard ratio (HR) = 10.04, 95% confidence interval (CI) = 7.58-13.30], as well as a history of esophageal ulcers (HR = 7.10, 95% CI = 5.03-10.01), alcohol abuse (HR = 5.46, 95% CI = 2.26-13.18), or esophageal reflux (HR = 1.86, 95% CI = 1.02-3.52), were factors associated with a higher risk of EC. And the dental prophylaxis group showed a significantly lower risk for EC (HR = 0.53, 95% CI = 0.44-0.65). Further subgroup analysis showed that the dental prophylaxis group among males had a significant lower risk (HR = 0.54, 95% CI = 0.44-0.66) for EC, while that of the females did not has statistically significant difference.
conclusionFor this cohort, subjects received dental prophylaxis reduced the risk of EC compared to all PD and no PD groups among males.
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