ArticleEmerging infectious diseases2014
Biomarker correlates of survival in pediatric patients with Ebola virus disease.
Article in Emerging infectious diseases, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 2 of them syntheses that pooled it.
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Who cites it
46 citing papers in PubMed, 2 syntheses or guidelines pooled it, 85 citations in OpenAlex.
- Risk factors for transmission of Ebola or Marburg virus disease: a systematic review and meta-analysis.International journal of epidemiology · 2016Pooled it
- Presence and Persistence of Ebola or Marburg Virus in Patients and Survivors: A Rapid Systematic Review.PLoS neglected tropical diseases · 2016Pooled it
- Mapping of susceptibility loci for Ebola virus pathogenesis in mice.Cell reports · 2024Article
- A causal multiomics study discriminates the early immune features of Ad5-vectored Ebola vaccine recipients.Innovation (Cambridge (Mass.)) · 2024Article
- Peripheral immune responses to filoviruses in a reservoir versus spillover hosts reveal transcriptional correlates of disease.Frontiers in immunology · 2023Article
- Natural history ofEmerging microbes & infections · 2022Article
- Virus kinetics and biochemical derangements among children with Ebolavirus disease.EClinicalMedicine · 2022Article
- Constructing, validating, and updating machine learning models to predict survival in children with Ebola Virus Disease.PLoS neglected tropical diseases · 2022Article
- A recombinant VSV-vectored vaccine rapidly protects nonhuman primates against lethal Nipah virus disease.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Article
- Factors associated with progression to death in patients with Lassa fever in Nigeria: an observational study.The Lancet. Infectious diseases · 2021Observational
- Renal Manifestations of Covid-19: Physiology and Pathophysiology.Journal of clinical medicine · 2021Review
- Do COVID-19 Infections Result in a Different Form of Secondary Hemophagocytic Lymphohistiocytosis.International journal of molecular sciences · 2021Review
- Platelets and renal failure in the SARS-CoV-2 syndrome.Platelets · 2021Article
- Immunologic timeline of Ebola virus disease and recovery in humans.JCI insight · 2020Article
- Cytokine Effects on the Entry of Filovirus Envelope Pseudotyped Virus-Like Particles into Primary Human Macrophages.Viruses · 2019Article
- Epidemiological characteristics, clinical manifestations, and treatment outcome of 139 paediatric Ebola patients treated at a Sierra Leone Ebola treatment center.BMC infectious diseases · 2019Observational
- Characterization of the plasma proteome of nonhuman primates during Ebola virus disease or melioidosis: a host response comparison.Clinical proteomics · 2019Article
- Kinetics of Soluble Mediators of the Host Response in Ebola Virus Disease.The Journal of infectious diseases · 2018Article
- Care of Ebola Survivors and Factors Associated With Clinical Sequelae-Monrovia, Liberia.Open forum infectious diseases · 2018Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Outbreaks of Ebola virus disease (EVD) occur sporadically in Africa and are associated with high case-fatality rates. Historically, children have been less affected than adults. The 2000-2001 Sudan virus-associated EVD outbreak in the Gulu district of Uganda resulted in 55 pediatric and 161 adult laboratory-confirmed cases. We used a series of multiplex assays to measure the concentrations of 55 serum analytes in specimens from patients from that outbreak to identify biomarkers specific to pediatric disease. Pediatric patients who survived had higher levels of the chemokine regulated on activation, normal T-cell expressed and secreted marker and lower levels of plasminogen activator inhibitor 1, soluble intracellular adhesion molecule, and soluble vascular cell adhesion molecule than did pediatric patients who died. Adult patients had similar levels of these analytes regardless of outcome. Our findings suggest that children with EVD may benefit from different treatment regimens than those for adults.
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Registered trials
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