E pluribus unum? The main protein kinase A catalytic subunit (PRKACA), a likely oncogene, and cortisol-producing tumors.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

17 citing papers in PubMed.

1. Construction of Pyroptosis-Related Prognostic and Immune Infiltration Signature in Bladder Cancer.Disease markers · 2022
   Article
2. Insulin-like growth factor 2 (IGF2) expression in adrenocortical disease due to PRKAR1A mutations compared to other benign adrenal tumors.Endocrine · 2021
   Article
3. PRKACB variants in skeletal disease or adrenocortical hyperplasia: effects on protein kinase A.Endocrine-related cancer · 2020
   Article
4. ARMC5 variants in PRKAR1A-mutated patients modify cortisol levels and Cushing's syndrome.Endocrine-related cancer · 2020
   Article
5. Called and Uncalled for Functions of the Main Catalytic Subunit of Protein Kinase A: One Enzyme, Many Faces.Endocrinology · 2019
   Article
6. Histopathological and genetic characterization of aldosterone-producing adenomas with concurrent subclinical cortisol hypersecretion: a case series.Endocrine · 2017
   Article
7. Lipofuscin Accumulation in Cortisol-Producing Adenomas With and Without PRKACA Mutations.Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme · 2017
   Article
8. Diagnosis and Clinical Genetics of Cushing Syndrome in Pediatrics.Endocrinology and metabolism clinics of North America · 2016
   Review
9. Protein kinase A catalytic subunit isoform PRKACA; History, function and physiology.Gene · 2016
   Review
10. 5th International ACC Symposium: The New Genetics of Benign Adrenocortical Neoplasia: Hyperplasias, Adenomas, and Their Implications for Progression into Cancer.Hormones & cancer · 2016
    Review
11. Steroidogenic Acute Regulatory Protein Overexpression Correlates with Protein Kinase A Activation in Adrenocortical Adenoma.PloS one · 2016
    Article
12. Hyperplasia in glands with hormone excess.Endocrine-related cancer · 2016
    Review
13. Haploinsufficiency for either one of the type-II regulatory subunits of protein kinase A improves the bone phenotype of Prkar1a+/- mice.Human molecular genetics · 2015
    Article
14. Phosphodiesterase 8B and cyclic AMP signaling in the adrenal cortex.Endocrine · 2015
    Review
15. Protein kinase A defects and cortisol-producing adrenal tumors.Current opinion in endocrinology, diabetes, and obesity · 2015
    Review
16. Germline PRKACA amplification causes variable phenotypes that may depend on the extent of the genomic defect: molecular mechanisms and clinical presentations.European journal of endocrinology · 2015
    Article
17. PRKACA: the catalytic subunit of protein kinase A and adrenocortical tumors.Frontiers in cell and developmental biology · 2015
    Review

Corrections and comments

• Comment on
  Novel somatic mutations in the catalytic subunit of the protein kinase A as a cause of adrenal Cushing's syndrome: a European multicentric study.2014
• Erratum issued
  Corrigenda.2015

Authors and funding

1 author.

Funding

Abstract

PubMed holds no abstract for this paper.

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