ArticlePloS one2014
Reduced topological efficiency in cortical-basal Ganglia motor network of Parkinson's disease: a resting state fMRI study.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 22 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 45 citations in OpenAlex.
- Functional brain changes in Parkinson's disease: a whole brain ALE study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022Pooled it
- Resting-state functional reorganization in Parkinson's disease: An activation likelihood estimation meta-analysis.Cortex; a journal devoted to the study of the nervous system and behavior · 2017Pooled it
- Combined brain topological metrics with machine learning to distinguish essential tremor and tremor-dominant Parkinson's disease.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024Article
- Mathematical derivation and mechanism analysis of beta oscillations in a cortex-pallidum model.Cognitive neurodynamics · 2024Article
- Age and sex differentially shape brain networks in Parkinson's disease.CNS neuroscience & therapeutics · 2023Article
- Classification of Parkinson's disease using a region-of-interest- and resting-state functional magnetic resonance imaging-based radiomics approach.Brain imaging and behavior · 2022Article
- Directed Brain Connectivity Identifies Widespread Functional Network Abnormalities in Parkinson's Disease.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Impaired Brain Information Transmission Efficiency and Flexibility in Parkinson's Disease and Rapid Eye Movement Sleep Behavior Disorder: Evidence from Functional Connectivity and Functional Dynamics.Parkinson's disease · 2022Article
- Structural Network Analysis Using Diffusion MRI Tractography in Parkinson's Disease and Correlations With Motor Impairment.Frontiers in neurology · 2020Article
- Association of olfaction dysfunction with brain microstructure in prodromal Parkinson disease.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2019Article
- Predicting the Post-therapy Severity Level (UPDRS-III) of Patients With Parkinson's Disease After Drug Therapy by Using the Dynamic Connectivity Efficiency of fMRI.Frontiers in neurology · 2019Article
- Brain imaging of locomotion in neurological conditions.Neurophysiologie clinique = Clinical neurophysiology · 2018Review
- Clinical pain and functional network topology in Parkinson's disease: a resting-state fMRI study.Journal of neural transmission (Vienna, Austria : 1996) · 2018Article
- Resting-state connectivity in neurodegenerative disorders: Is there potential for an imaging biomarker?NeuroImage. Clinical · 2018Review
- Correction: Reduced Topological Efficiency in Cortical-Basal Ganglia Motor Network of Parkinson's Disease: A Resting State fMRI Study.PloS one · 2018Article
- Article
- Analysis of structure-function network decoupling in the brain systems of spastic diplegic cerebral palsy.Human brain mapping · 2017Article
- Characterization of the resting-state brain network topology in the 6-hydroxydopamine rat model of Parkinson's disease.PloS one · 2017Article
- Characterizing structural neural networks in de novo Parkinson disease patients using diffusion tensor imaging.Human brain mapping · 2016Article
- Disrupted Nodal and Hub Organization Account for Brain Network Abnormalities in Parkinson's Disease.Frontiers in aging neuroscience · 2016Article
Corrections and comments
- Erratum issued
- Erratum issued
Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Parkinson's disease (PD) is mainly characterized by dopamine depletion of the cortico-basal ganglia (CBG) motor circuit. Given that dopamine dysfunction could affect functional brain network efficiency, the present study utilized resting-state fMRI (rs-fMRI) and graph theoretical approach to investigate the topological efficiency changes of the CBG motor network in patients with PD during a relatively hypodopaminergic state (12 hours after a last dose of dopamimetic treatment). We found that PD compared with controls had remarkable decreased efficiency in the CBG motor network, with the most pronounced changes observed in rostral supplementary motor area (pre-SMA), caudal SMA (SMA-proper), primary motor cortex (M1), primary somatosensory cortex (S1), thalamus (THA), globus pallidus (GP), and putamen (PUT). Furthermore, reduced efficiency in pre-SMA, M1, THA and GP was significantly correlated with Unified Parkinson's Disease Rating Scale (UPDRS) motor scores in PD patients. Together, our results demonstrate that individuals with PD appear to be less effective at information transfer within the CBG motor pathway, which provides a novel perspective on neurobiological explanation for the motor symptoms in patients. These findings are in line with the pathophysiology of PD, suggesting that network efficiency metrics may be used to identify and track the pathology of PD.
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