ArticleThe Journal of clinical endocrinology and metabolism2014
Leptin therapy alters appetite and neural responses to food stimuli in brain areas of leptin-sensitive subjects without altering brain structure.
Article in The Journal of clinical endocrinology and metabolism, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.
- Neural Correlates of Anti-appetite Medications: An fMRI Meta-analysis.Current neuropharmacology · 2021Pooled it
- Walnut consumption increases activation of the insula to highly desirable food cues: A randomized, double-blind, placebo-controlled, cross-over fMRI study.Diabetes, obesity & metabolism · 2018Trial
- Intranasal insulin enhances brain functional connectivity mediating the relationship between adiposity and subjective feeling of hunger.Scientific reports · 2017Trial
- Trial
- Short-term administration of the GLP-1 analog liraglutide decreases circulating leptin and increases GIP levels and these changes are associated with alterations in CNS responses to food cues: A randomized, placebo-controlled, crossover study.Metabolism: clinical and experimental · 2016Trial
- Skim milk hydrolysate (SMH-AP) containing AVPYP and GLPQE ameliorates adipogenic lipid accumulation in 3T3-L1 cells.Nutrition research and practice · 2026Article
- Assessment of aortomesenteric distance and mesenteric and retroperitoneal adipose tissue thickness in genetic forms of lipodystrophy.Journal of endocrinological investigation · 2025Article
- Higher-Order Inputs Involved in Appetite Control.Biological psychiatry · 2022Review
- Ccrl2 deficiency deteriorates obesity and insulin resistance through increasing adipose tissue macrophages infiltration.Genes & diseases · 2022Article
- Behavioral, Hormonal, and Serotonergic Responses to Different Restricted Feeding Schedules in Rats.International journal of tryptophan research : IJTR · 2022Article
- Leptin in Leanness and Obesity: JACC State-of-the-Art Review.Journal of the American College of Cardiology · 2021Review
- Leptin alters energy intake and fat mass but not energy expenditure in lean subjects.Nature communications · 2020Article
- Review
- Psychopathological and psychiatric evaluation of patients affected by lipodystrophy.Eating and weight disorders : EWD · 2020Article
- Appetite changes reveal depression subgroups with distinct endocrine, metabolic, and immune states.Molecular psychiatry · 2020Article
- GEOFFREY HARRIS PRIZE LECTURE 2018: Novel pathways regulating neuroendocrine function, energy homeostasis and metabolism in humans.European journal of endocrinology · 2019Review
- Obese individuals with more components of the metabolic syndrome and/or prediabetes demonstrate decreased activation of reward-related brain centers in response to food cues in both the fed and fasting states: a preliminary fMRI study.International journal of obesity (2005) · 2017Article
- Differential effects of hunger and satiety on insular cortex and hypothalamic functional connectivity.The European journal of neuroscience · 2016Article
- The Effects of Leptin Replacement on Neural Plasticity.Neural plasticity · 2016Review
- Can We Selectively Reduce Appetite for Energy-Dense Foods? An Overview of Pharmacological Strategies for Modification of Food Preference Behavior.Current neuropharmacology · 2016Review
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
Abstract
contextLeptin is a key regulator of energy intake and expenditure. Individuals with congenital leptin deficiency demonstrate structural and functional brain changes when given leptin. However, whether acquired leptin deficiency may operate similarly is unclear.
objectiveWe set out to determine whether the brains of individuals with acquired leptin deficiency may react to leptin in a similar manner.
designWe used functional magnetic resonance imaging before and after short- and long-term metreleptin treatment in three leptin-sensitive patients with acquired hypoleptinemia. Nine healthy women were scanned as normoleptinemic controls.
settingThe setting was an academic medical center. PATIENTS OR OTHER
participantsThe participants were 3 hypoleptinemic women and nine normoleptinemic, matched women.
interventionsWe used metreleptin, recombinant leptin, therapy for 24 weeks in hypoleptinemic women only.
main outcome measureWe measured neural changes in response to viewing food as compared to nonfood images. We hypothesized that metreleptin treatment would increase brain activity in areas related to cognitive control and inhibition and would decrease brain activity in areas related to reward processing, as compared to the normoleptinemic counterparts.
resultsUnlike patients with congenital leptin deficiency, hypoleptinemic patients demonstrated no structural brain differences from healthy controls and/or structural changes in response to treatment. Short-term metreleptin treatment in leptin-sensitive hypoleptinemic subjects enhances areas involved in detecting the salience and rewarding value of food during fasting, whereas long-term treatment decreases attention to food and the rewarding value of food after feeding. Furthermore, hypothalamic activity is modulated by metreleptin treatment, and leptin decreases functional connectivity of the hypothalamus to key feeding-related areas in these hypoleptinemic subjects.
conclusionsLeptin replacement in acutely hypoleptinemic women did not alter brain structure but did alter functional cortical activity to food cues in key feeding and reward-related areas.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.