ArticleThe Plant journal : for cell and molecular biology2015
Modelling central metabolic fluxes by constraint-based optimization reveals metabolic reprogramming of developing Solanum lycopersicum (tomato) fruit.
Article in The Plant journal : for cell and molecular biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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40 citing papers in PubMed.
- A sugar flow model predicts cell dynamics, weight, and quality of tomato at varying sink-source ratios and temperatures.Journal of experimental botany · 2026Article
- Mitochondrial glutamine synthetase overexpression in tomato source leaves increases assimilate export and fruit yield.The Plant cell · 2026Article
- Deciphering the interplay between fruit-associated metabolites and bacterial communities across four distinct mango cultivars.Frontiers in plant science · 2026Article
- In silico encounters: harnessing metabolic modelling to understand plant-microbe interactions.FEMS microbiology reviews · 2025Review
- Grapevine cell response to carbon deficiency requires transcriptome and methylome reprogramming.Horticulture research · 2025Article
- From Division to Death: Metabolomic Analysis ofPlants (Basel, Switzerland) · 2024Article
- Sustained carbon import supports sugar accumulation and anthocyanin biosynthesis during fruit development and ripening in blueberry (Vaccinium ashei).Scientific reports · 2024Article
- Modelling metabolic fluxes of tomato stems reveals that nitrogen shapes central metabolism for defence against Botrytis cinerea.Journal of experimental botany · 2024Article
- Plant Heterotrophic Cultures: No Food, No Growth.Plants (Basel, Switzerland) · 2024Review
- Plant Life with and without Oxygen: A Metabolomics Approach.International journal of molecular sciences · 2023Review
- Toward mechanistic modeling and rational engineering of plant respiration.Plant physiology · 2023Article
- Genome-scale metabolic model led engineering ofFrontiers in plant science · 2023Article
- Elucidating the impact ofFrontiers in plant science · 2023Article
- From fruit growth to ripening in plantain: a careful balance between carbohydrate synthesis and breakdown.Journal of experimental botany · 2022Article
- A multi-organ metabolic model of tomato predicts plant responses to nutritional and genetic perturbations.Plant physiology · 2022Article
- The NAC transcription factor FaRIF controls fruit ripening in strawberry.The Plant cell · 2021Article
- The Contribution of Metabolomics to Systems Biology: Current Applications Bridging Genotype and Phenotype in Plant Science.Advances in experimental medicine and biology · 2021Article
- Biomass composition explains fruit relative growth rate and discriminates climacteric from non-climacteric species.Journal of experimental botany · 2020Article
- Model-assisted comparison of sugar accumulation patterns in ten fleshy fruits highlights differences between herbaceous and woody species.Annals of botany · 2020Article
- Unraveling dynamic metabolomes underlying different maturation stages of berries harvested fromJournal of ginseng research · 2020Article
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11 authors.
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Abstract
Modelling of metabolic networks is a powerful tool to analyse the behaviour of developing plant organs, including fruits. Guided by our current understanding of heterotrophic metabolism of plant cells, a medium-scale stoichiometric model, including the balance of co-factors and energy, was constructed in order to describe metabolic shifts that occur through the nine sequential stages of Solanum lycopersicum (tomato) fruit development. The measured concentrations of the main biomass components and the accumulated metabolites in the pericarp, determined at each stage, were fitted in order to calculate, by derivation, the corresponding external fluxes. They were used as constraints to solve the model by minimizing the internal fluxes. The distribution of the calculated fluxes of central metabolism were then analysed and compared with known metabolic behaviours. For instance, the partition of the main metabolic pathways (glycolysis, pentose phosphate pathway, etc.) was relevant throughout fruit development. We also predicted a valid import of carbon and nitrogen by the fruit, as well as a consistent CO2 release. Interestingly, the energetic balance indicates that excess ATP is dissipated just before the onset of ripening, supporting the concept of the climacteric crisis. Finally, the apparent contradiction between calculated fluxes with low values compared with measured enzyme capacities suggest a complex reprogramming of the metabolic machinery during fruit development. With a powerful set of experimental data and an accurate definition of the metabolic system, this work provides important insight into the metabolic and physiological requirements of the developing tomato fruits.
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