ArticleSpringerPlus2014
The sheep KAP8-2 gene, a new KAP8 family member that is absent in humans.
Article in SpringerPlus, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 26 citations in OpenAlex.
- Wool: From Properties and Structure to Genetic Insights and Sheep Improvement Strategies.Animals : an open access journal from MDPI · 2025Review
- Exploring Variation in OvineAnimals : an open access journal from MDPI · 2024Article
- Identification of the Keratin-Associated Protein 22-2 Gene in theAnimals : an open access journal from MDPI · 2023Article
- Sequence Variation in CaprineAnimals : an open access journal from MDPI · 2022Article
- The Complexity of the Ovine and Caprine Keratin-Associated Protein Genes.International journal of molecular sciences · 2021Review
- Characterization and functional analysis of Krtap11-1 during hair follicle development in Angora rabbits (Oryctolagus cuniculus).Genes & genomics · 2020Article
- Variation in the KRTAP6-3 gene and its association with wool characteristics in Pakistani sheep breeds and breed-crosses.Tropical animal health and production · 2020Article
- Polymorphism in the ovine keratin-associated protein gene KRTAP7-1 and its association with wool characteristics.Journal of animal science · 2020Article
- Article
- Identification of the Ovine Keratin-Associated Protein 21-1 Gene and Its Association with Variation in Wool Traits.Animals : an open access journal from MDPI · 2019Article
- Identification of Ovine KRTAP28-1 and Its Association with Wool Fibre Diameter.Animals : an open access journal from MDPI · 2019Article
- Associations between variation in the ovine high glycine-tyrosine keratin-associated protein gene KRTAP20-1 and wool traits.Journal of animal science · 2019Article
- Variation inArchives animal breeding · 2019Article
- Article
- Article
- Review
- Identification of four new gene members of the KAP6 gene family in sheep.Scientific reports · 2016Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The keratin-associated proteins (KAPs) are fundamental components of hair and wool fibres, and are believed to in part be responsible for some of the properties of these fibres. KAPs can be divided into three groups: the high sulphur (HS) KAPs, the ultra-high sulphur (UHS) KAPs and the high glycine-tyrosine (HGT) KAPs. KAP8 is a HGT-KAP family and was believed to be coded for by a single gene in both humans and sheep. However, the recent identification of a KAP8-2 gene in goats led us to investigate whether a KAP8-2 gene exists in sheep. A BLAST search of the Ovine Genome Assembly v2.0 using the coding sequence of caprine KRTAP8-2 identified a homologous region on sheep chromosome 1 (OAR1:123005473_123005664; E = e(-101)). This region was clustered with a number of previously identified KAP genes including (in order from the centromere) KRTAP11-1, KRTAP7-1, KRTAP8-1, KRTAP6-2, KRTAP6-1, KRTAP13-3 and KRTAP24-1. PCR-SSCP analysis of the notional gene revealed two dissimilar PCR-SSCP banding patterns, representing two DNA sequences. A single nucleotide difference 21 bp upstream of the TATA box was identified. The two sequences did not have great homology with known ovine KRTAP sequences, but high sequence identity was found with KRTAP8-2 from goats and reindeer. These results suggest that sheep possess a KAP8-2 gene and that this gene is polymorphic. The notional KAP8-2 protein is comprised of 63 amino acid residues and is rich in glycine and tyrosine, but has a low cysteine content. In contrast to other HGT-KAPs, ovine KAP8-2 contains more acidic amino acid residues, and this would likely result in a lower isoelectric point (pI) of 6.3.
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