ArticleSpringerPlus2014
Creatine metabolism differs between mammals and rainbow trout (Oncorhynchus mykiss).
Article in SpringerPlus, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 43 citations in OpenAlex.
- Fuelled by creatine: exploring two copies of the creatine transporter SLC6A8 gene in rainbow trout.Fish physiology and biochemistry · 2026Article
- Performance Responses and Fillet Quality of Rainbow Trout (Animals : an open access journal from MDPI · 2025Article
- Creatine Ameliorates the Adverse Effects of High-Fat Diet on Hepatic Lipid MetabolismAquaculture nutrition · 2025Article
- Integrative Metabolomics, Enzymatic Activity, and Gene Expression Analysis Provide Insights into the Metabolic Profile Differences between the Slow-Twitch Muscle and Fast-Twitch Muscle ofInternational journal of molecular sciences · 2024Article
- Dietary glycine supplementation enhances syntheses of creatine and glutathione by tissues of hybrid striped bass (Morone saxatilis ♀ × Morone chrysops ♂) fed soybean meal-based diets.Journal of animal science and biotechnology · 2024Article
- Assessment of Salinomycin's Potential to TreatAnimals : an open access journal from MDPI · 2023Article
- Metabolites, gene expression, and gut microbiota profiles suggest the putative mechanisms via which dietary creatine increases the serum taurine and g-ABA contents in Megalobrama amblycephala.Fish physiology and biochemistry · 2023Article
- Article
- Hematological and serum biochemical reference intervals of rainbow trout,Saudi journal of biological sciences · 2022Article
- Fish Allergenicity Modulation Using Tailored Enriched Diets-Where Are We?Frontiers in physiology · 2022Review
- Organ-Specific Metabolome Deciphering Cell Pathways to Cope with Mercury in Wild Fish (Golden Grey MulletAnimals : an open access journal from MDPI · 2021Article
- Beyond mitochondria: Alternative energy-producing pathways from all strata of life.Metabolism: clinical and experimental · 2021Review
- Insights into early ontogenesis: characterization of stress and development key genes of pikeperch (Sander lucioperca) in vivo and in vitro.Fish physiology and biochemistry · 2021Article
- Parallel selection on ecologically relevant gene functions in the transcriptomes of highly diversifying salmonids.BMC genomics · 2019Article
- Evolutionary expression differences of creatine synthesis-related genes: Implications for skeletal muscle metabolism in fish.Scientific reports · 2019Article
- Dietary Creatine Supplementation in Gilthead Seabream (Frontiers in endocrinology · 2019Article
- Dietary Creatine Supplementation in Gilthead Seabream (Frontiers in physiology · 2018Article
- Identification of genes involved in cold-shock response in rainbow trout (Oncorhynchus mykiss).Journal of genetics · 2017Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Creatine plays an important role in the cell as an energy buffer. As the energy system is a basic element of the organism it may possibly contribute to differences between rainbow trout strains selected for the traits growth and robustness, respectively. The cDNA sequences of creatine-related genes encoding glycine amidinotransferase (GATM), guanidinoacetate N-methyltransferase (GAMT), creatine kinase muscle-type (CKM) and creatine transporter 1 (CT1, encoded by gene solute carrier family 6, member 8 (SLC6A8)) were characterized in rainbow trout. Transcripts of the respective genes were quantified in kidney, liver, brain and skeletal muscle in both trout strains that had been acclimated to different temperatures. Several differences between the compared trout strains were found as well as between temperatures indicating that the energy system may contribute to differences between both strains. In addition to that, the expression data showed clear differences between the creatine system in rainbow trout and mammals, as the spatial distribution of the enzyme-encoding gene expression was clearly different from the patterns described for mammals. In rainbow trout, creatine synthesis seems to take place to a big extent in the skeletal muscle.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.