Evidence map›Paper›PMID 25279122›Full record

ArticleJournal of ophthalmic & vision research2014

Retinal biocompatibility of brilliant blue g with deuterated water for chromovitrectomy.

Emmerson Badaró, Milton Moraes-Filho, Mauricio Maia, Fernando M Penha, Eduardo Amorim Novais, Rodrigo A Souza-Lima, Flavio Hirai, Carsten H Meyer, Michel Eid Farah, Eduardo B Rodrigues

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In one paragraph

Article in Journal of ophthalmic & vision research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 94% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Emmerson BadaróDepartment of Ophthalmology, Vision Institute (IPEPO), Federal University of São Paulo, São Paulo, Brazil.
Milton Moraes-FilhoDepartment of Ophthalmology, Vision Institute (IPEPO), Federal University of São Paulo, São Paulo, Brazil.
Mauricio MaiaDepartment of Ophthalmology, Vision Institute (IPEPO), Federal University of São Paulo, São Paulo, Brazil.
Fernando M PenhaDepartment of Ophthalmology, Vision Institute (IPEPO), Federal University of São Paulo, São Paulo, Brazil.
Eduardo Amorim NovaisDepartment of Ophthalmology, Vision Institute (IPEPO), Federal University of São Paulo, São Paulo, Brazil.
Rodrigo A Souza-LimaDepartment of Ophthalmology, Vision Institute (IPEPO), Federal University of São Paulo, São Paulo, Brazil.
Flavio HiraiDepartment of Ophthalmology, Vision Institute (IPEPO), Federal University of São Paulo, São Paulo, Brazil.
Carsten H MeyerDepartment of Ophthalmology, University of Bonn, Bonn, Germany.
Michel Eid FarahDepartment of Ophthalmology, Vision Institute (IPEPO), Federal University of São Paulo, São Paulo, Brazil.
Eduardo B RodriguesDepartment of Ophthalmology, Vision Institute (IPEPO), Federal University of São Paulo, São Paulo, Brazil.
Instituto da Visão · BRUniversidade Federal de São Paulo · BRUniversity of Bonn · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo investigate the retinal biocompatibility of Brilliant Blue G with deuterated water (BBG-D2O) as a vital dye for chromovitrectomy.

methodsIn this animal study, 0.05 mL of 0.25 g/L Brilliant Blue G (BBG) associated with 0.13 mL/mL of deuterium oxide (D2O) was injected intravitreally in the right eye and the same amount of balanced salt solution (BSS) was injected similarly in the left eye of rabbits. Clinical examination and histology with light microscopy were performed after seven days. Retinal cell layers were evaluated for morphologic alterations. Electroretinographic (ERG) changes were also assessed at baseline and 7 days after the injections.

resultsA total of 6 rabbits were included in the study. The gross histopathologic appearance of the retina, choroid, sclera and optic nerve was within normal limits without any sign of severe retinal necrosis or cystic degeneration. Light microscopy showed that BBG-D2O caused no substantial alterations in retinal layers as compared to control eyes. The injection of BBG-D2O did not induce considerable functional ERG alterations.

conclusionIntravitreal injection of BBG-D2O 0.25 g/L seems to induce no retinal toxicity as documented by lack of functional and histological changes.

Indexed as

Brillant BlueChromovitrectomyDeuterated WaterRetinal Toxicity

Identifiers

PMID25279122
PMCPMC4181203
OpenAlexW1701689309

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.