Evidence map›Paper›PMID 25278877›Full record

ReviewFrontiers in aging neuroscience2014

Pericytes: multitasking cells in the regeneration of injured, diseased, and aged skeletal muscle.

Alexander Birbrair, Tan Zhang, Zhong-Min Wang, Maria L Messi, Akiva Mintz, Osvaldo Delbono

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in aging neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 87 papers.

0numbers the graph read from it
0cells of the map it votes in
87citing papers in PubMed
6.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

87 citing papers in PubMed, 128 citations in OpenAlex.

  1. Review
  2. Article
  3. Mechanisms of Pericyte-Mediated Cancer Metastasis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  4. Article
  5. Review
  6. Review
  7. Review
  8. Article
  9. Signaling Role of Pericytes in Vascular Health and Tissue Homeostasis.International journal of molecular sciences · 2024
    Review
  10. Article
  11. MuSCs and IPCs: roles in skeletal muscle homeostasis, aging and injury.Cellular and molecular life sciences : CMLS · 2024
    Review
  12. Review
  13. Glioma Pericytes Promote Angiogenesis by Producing Periostin.Cellular and molecular neurobiology · 2022
    Review
  14. Therapeutic Effect of Pericytes for Diabetic Wound Healing.Frontiers in cardiovascular medicine · 2022
    Article
  15. Article
  16. Circulating Nestin-GFPStem cell reviews and reports · 2021
    Article
  17. Article
  18. Review
  19. Sensory nerves in the spotlight of the stem cell niche.Stem cells translational medicine · 2021
    Review
  20. Article

27 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Alexander BirbrairDepartment of Internal Medicine-Gerontology, Wake Forest School of Medicine Winston-Salem, NC, USA ; Neuroscience Program, Wake Forest School of Medicine Winston-Salem, NC, USA.
Tan ZhangDepartment of Internal Medicine-Gerontology, Wake Forest School of Medicine Winston-Salem, NC, USA.
Zhong-Min WangDepartment of Internal Medicine-Gerontology, Wake Forest School of Medicine Winston-Salem, NC, USA.
Maria L MessiDepartment of Internal Medicine-Gerontology, Wake Forest School of Medicine Winston-Salem, NC, USA.
Akiva MintzDepartment of Neurosurgery, Wake Forest School of Medicine Winston-Salem, NC, USA.
Osvaldo DelbonoDepartment of Internal Medicine-Gerontology, Wake Forest School of Medicine Winston-Salem, NC, USA ; Neuroscience Program, Wake Forest School of Medicine Winston-Salem, NC, USA.
Wake Forest University · US

Funding

Tumor Tissue CoreP30CA012197 · NCI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Ruben A. Mesa · 1985 to 2026
$55.4M
Wake Forest Claude D. Pepper OAIC - RenewalP30AG021332 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Jamie Nicole Justice · 2002 to 2026
$36.4M
Tropin T and Excitation-Contraction Coupling in Aging Skeletal MuscleR01AG013934 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI DELBONO, OSVALDO · 2001 to 2017
$4.7M
Age-Dependent Regulation of Excitation-Contraction CouplingR01AG015820 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI DELBONO, OSVALDO · 1998 to 2013
$3.4M
SINGLE SKETETAL MUSCLE FIBER IMPAIRMENT WITH AGINGR29AG013934 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI DELBONO, OSVALDO · 1997 to 2000
$104k
NCI NIH HHS P30 CA012197NIA NIH HHS P30 AG021332NIA NIH HHS R01 AG013934NIA NIH HHS R01 AG015820NIA NIH HHS R29 AG013934
6 · The paper itself

Abstract

Pericytes are perivascular cells that envelop and make intimate connections with adjacent capillary endothelial cells. Recent studies show that they may have a profound impact in skeletal muscle regeneration, innervation, vessel formation, fibrosis, fat accumulation, and ectopic bone formation throughout life. In this review, we summarize and evaluate recent advances in our understanding of pericytes' influence on adult skeletal muscle pathophysiology. We also discuss how further elucidating their biology may offer new approaches to the treatment of conditions characterized by muscle wasting.

Indexed as

agingangiogenesisfat formationfibrous tissueinnervationpericytesregenerationskeletal muscle

Identifiers

PMID25278877
PMCPMC4166895
OpenAlexW2025566941

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.