ArticleFrontiers in cellular neuroscience2014
Spiny neurons of amygdala, striatum, and cortex use dendritic plateau potentials to detect network UP states.
Article in Frontiers in cellular neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Behavioral timescale synaptic plasticity: properties, elements and functions.Nature neuroscience · 2026Review
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- Behavioral Timescale Synaptic Plasticity: A Burst in the Field of Learning and Memory.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Review
- Nonlinear Dendritic Integration Supports Up-Down States in Single Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- An unusual potassium conductance protectsProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Enhanced electrophysiological recordings in acute brain slices, spheroids, and organoids using 3D high-density multielectrode arrays.PloS one · 2025Article
- Effects of ketamine and propofol on muscarinic plateau potentials in rat neocortical pyramidal cells.PloS one · 2025Article
- Wrap it up: myelination of transplanted neurons for repair.Frontiers in cellular neuroscience · 2025Review
- Deficits in integrative NMDA receptors caused by Grin1 disruption can be rescued in adulthood.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Article
- Glutamate spillover drives robust all-or-none dendritic plateau potentials-anFrontiers in cellular neuroscience · 2023Article
- Striatal synaptic adaptations in Parkinson's disease.Neurobiology of disease · 2022Review
- Studying Synaptically Evoked Cortical ResponsesFrontiers in neuroscience · 2021Article
- Article
- Embedded ensemble encoding hypothesis: The role of the "Prepared" cell.Journal of neuroscience research · 2018Review
- Cortico-Amygdala-Striatal Activation by Modafinil/Flecainide Combination.The international journal of neuropsychopharmacology · 2018Article
- Nonlinear Relationship Between Spike-Dependent Calcium Influx and TRPC Channel Activation Enables Robust Persistent Spiking in Neurons of the Anterior Cingulate Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Selective effects of Δ9-tetrahydrocannabinol on medium spiny neurons in the striatum.PloS one · 2018Article
- The stochastic nature of action potential backpropagation in apical tuft dendrites.Journal of neurophysiology · 2017Article
- Calcium regulation of HCN channels supports persistent activity in a multiscale model of neocortex.Neuroscience · 2016Article
- The human medial amygdala: structure, diversity, and complexity of dendritic spines.Journal of anatomy · 2015Article
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4 authors.
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Abstract
SPINY NEURONS OF AMYGDALA, STRIATUM, AND CEREBRAL CORTEX SHARE FOUR INTERESTING FEATURES: (1) they are the most abundant cell type within their respective brain area, (2) covered by thousands of thorny protrusions (dendritic spines), (3) possess high levels of dendritic NMDA conductances, and (4) experience sustained somatic depolarizations in vivo and in vitro (UP states). In all spiny neurons of the forebrain, adequate glutamatergic inputs generate dendritic plateau potentials ("dendritic UP states") characterized by (i) fast rise, (ii) plateau phase lasting several hundred milliseconds, and (iii) abrupt decline at the end of the plateau phase. The dendritic plateau potential propagates toward the cell body decrementally to induce a long-lasting (longer than 100 ms, most often 200-800 ms) steady depolarization (∼20 mV amplitude), which resembles a neuronal UP state. Based on voltage-sensitive dye imaging, the plateau depolarization in the soma is precisely time-locked to the regenerative plateau potential taking place in the dendrite. The somatic plateau rises after the onset of the dendritic voltage transient and collapses with the breakdown of the dendritic plateau depolarization. We hypothesize that neuronal UP states in vivo reflect the occurrence of dendritic plateau potentials (dendritic UP states). We propose that the somatic voltage waveform during a neuronal UP state is determined by dendritic plateau potentials. A mammalian spiny neuron uses dendritic plateau potentials to detect and transform coherent network activity into a ubiquitous neuronal UP state. The biophysical properties of dendritic plateau potentials allow neurons to quickly attune to the ongoing network activity, as well as secure the stable amplitudes of successive UP states.
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