ReviewFrontiers in neuroscience2014
Restoration of motor function following spinal cord injury via optimal control of intraspinal microstimulation: toward a next generation closed-loop neural prosthesis.
Review in Frontiers in neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 56 citations in OpenAlex.
- Closed-loop neuromodulation: a paradigm shift in precision neuroscience for clinical and cognitive applications.Frontiers in neuroscience · 2026Review
- Microelectrode arrays cultured with in vitro neural networks for motion control tasks: encoding and decoding progress and advances.Microsystems & nanoengineering · 2025Review
- Effects of iron accumulation and its chelation on oxidative stress in intracortical implants.Acta biomaterialia · 2025Article
- Imbalanced optimal feedback motor control system in spinocerebellar ataxia type 3.European journal of neurology · 2024Article
- Neurostimulation on lumbosacral nerves as a new treatment for spinal cord injury impairments and its impact on cortical activity: a narrative review.Frontiers in human neuroscience · 2024Review
- Regulation of the JAK/STAT signaling pathway in spinal cord injury: an updated review.Frontiers in immunology · 2023Review
- A flexible electrode array for determining regions of motor function activated by epidural spinal cord stimulation in rats with spinal cord injury.Neural regeneration research · 2022Article
- Organic electrochemical neurons and synapses with ion mediated spiking.Nature communications · 2022Article
- A biohybrid synapse with neurotransmitter-mediated plasticity.Nature materials · 2020Article
- Application of a neural interface for restoration of leg movements: Intra-spinal stimulation using the brain electrical activity in spinally injured rabbits.Journal of applied biomedicine · 2020Article
- Zwitterionic Polymer Coating Suppresses Microglial Encapsulation to Neural Implants In Vitro and In Vivo.Advanced biosystems · 2020Article
- Innovations in electrical stimulation harness neural plasticity to restore motor function.Bioelectronics in medicine · 2018Article
- A Brain-Spinal Interface (BSI) System-on-Chip (SoC) for Closed-Loop Cortically-Controlled Intraspinal Microstimulation.Analog integrated circuits and signal processing · 2018Article
- A Fully Integrated Wireless SoC for Motor Function Recovery After Spinal Cord Injury.IEEE transactions on biomedical circuits and systems · 2017Article
- Intraspinal microstimulation produces over-ground walking in anesthetized cats.Journal of neural engineering · 2016Article
- Article
- Restoring Behavior via Inverse Neurocontroller in a Lesioned Cortical Spiking Model Driving a Virtual Arm.Frontiers in neuroscience · 2016Article
- The Evolution of Neuroprosthetic Interfaces.Critical reviews in biomedical engineering · 2016Review
- Effects of electrical stimulation on rat limb regeneration, a new look at an old model.Scientific reports · 2015Article
- Neural prostheses for restoring functions lost after spinal cord injury.Neural regeneration research · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 1 country.
Funding
Abstract
Movement is planned and coordinated by the brain and carried out by contracting muscles acting on specific joints. Motor commands initiated in the brain travel through descending pathways in the spinal cord to effector motor neurons before reaching target muscles. Damage to these pathways by spinal cord injury (SCI) can result in paralysis below the injury level. However, the planning and coordination centers of the brain, as well as peripheral nerves and the muscles that they act upon, remain functional. Neuroprosthetic devices can restore motor function following SCI by direct electrical stimulation of the neuromuscular system. Unfortunately, conventional neuroprosthetic techniques are limited by a myriad of factors that include, but are not limited to, a lack of characterization of non-linear input/output system dynamics, mechanical coupling, limited number of degrees of freedom, high power consumption, large device size, and rapid onset of muscle fatigue. Wireless multi-channel closed-loop neuroprostheses that integrate command signals from the brain with sensor-based feedback from the environment and the system's state offer the possibility of increasing device performance, ultimately improving quality of life for people with SCI. In this manuscript, we review neuroprosthetic technology for improving functional restoration following SCI and describe brain-machine interfaces suitable for control of neuroprosthetic systems with multiple degrees of freedom. Additionally, we discuss novel stimulation paradigms that can improve synergy with higher planning centers and improve fatigue-resistant activation of paralyzed muscles. In the near future, integration of these technologies will provide SCI survivors with versatile closed-loop neuroprosthetic systems for restoring function to paralyzed muscles.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.