ArticleClinical cancer research : an official journal of the American Association for Cancer Research2009
An open letter to the FDA and other regulatory agencies: Preclinical drug development must consider the impact on metastasis.
Article in Clinical cancer research : an official journal of the American Association for Cancer Research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed.
- Predictive and prognostic angiogenic markers in a gynecologic oncology group phase II trial of bevacizumab in recurrent and persistent ovarian or peritoneal cancer.Gynecologic oncology · 2010Trial
- Accumulation of liposomes in metastatic tumor sites is not necessary for anti-cancer drug efficacy.Journal of translational medicine · 2024Article
- Inhibition of Metastasis by Polypyridyl Ru(II) Complexes through Modification of Cancer Cell Adhesion -Journal of medicinal chemistry · 2022Article
- Inter-Metastatic Heterogeneity of Tumor Marker Expression and Microenvironment Architecture in a Preclinical Cancer Model.International journal of molecular sciences · 2021Article
- A spontaneously metastatic model of bladder cancer: imaging characterization.Journal of translational medicine · 2019Article
- The Kraken Wakes: induced EMT as a driver of tumour aggression and poor outcome.Clinical & experimental metastasis · 2018Review
- Pragmatic medicine in solid cancer: a translational alternative to precision medicine.OncoTargets and therapy · 2016Article
- Stimulus-dependent differences in signalling regulate epithelial-mesenchymal plasticity and change the effects of drugs in breast cancer cell lines.Cell communication and signaling : CCS · 2015Article
- Neoadjuvant antiangiogenic therapy reveals contrasts in primary and metastatic tumor efficacy.EMBO molecular medicine · 2014Article
- Modeling spontaneous metastatic renal cell carcinoma (mRCC) in mice following nephrectomy.Journal of visualized experiments : JoVE · 2014Article
- A model of postsurgical advanced metastatic breast cancer more accurately replicates the clinical efficacy of antiangiogenic drugs.Cancer research · 2013Article
- Dynamic analysis of lung metastasis by mouse osteosarcoma LM8: VEGF is a candidate for anti-metastasis therapy.Clinical & experimental metastasis · 2013Article
- Article
- High antimetastatic efficacy of MEN4901/T-0128, a novel camptothecin carboxymethyldextran conjugate.The Journal of surgical research · 2011Article
- Antiangiogenic therapy: impact on invasion, disease progression, and metastasis.Nature reviews. Clinical oncology · 2011Review
- PG545, a dual heparanase and angiogenesis inhibitor, induces potent anti-tumour and anti-metastatic efficacy in preclinical models.British journal of cancer · 2011Article
- Mouse models of advanced spontaneous metastasis for experimental therapeutics.Nature reviews. Cancer · 2011Review
- Metastasis suppressor genes at the interface between the environment and tumor cell growth.International review of cell and molecular biology · 2011Review
- Cancer metastasis as a therapeutic target.European journal of cancer (Oxford, England : 1990) · 2010Review
- Impact of metronomic UFT/cyclophosphamide chemotherapy and antiangiogenic drug assessed in a new preclinical model of locally advanced orthotopic hepatocellular carcinoma.Neoplasia (New York, N.Y.) · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
Abstract
PubMed holds no abstract for this paper.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.