ArticleWorld journal of gastroenterology2014
Small-bowel mucosal injuries in low-dose aspirin users with obscure gastrointestinal bleeding.
Article in World journal of gastroenterology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 35 citations in OpenAlex.
- Development and validation of a risk prediction model for small intestinal mucosal injury in nonsteroidal anti-inflammatory drug users.World journal of gastrointestinal surgery · 2026Article
- Gut-Heart Axis: The Role of Gut Microbiota and Metabolites in Heart Failure.Circulation research · 2025Review
- A novel drug-like water-soluble small molecule Focal Adhesion Kinase (FAK) activator promotes intestinal mucosal healing.Current research in pharmacology and drug discovery · 2023Article
- New Trends and Advances in Non-Variceal Gastrointestinal Bleeding-Series II.Journal of clinical medicine · 2021Review
- Small bowel ulcer bleeding due to suspected clopidogrel use in a patient with clopidogrel resistance: A case report.World journal of clinical cases · 2021Article
- P2Y12 Inhibitors Exacerbate Low-dose Aspirin-induced Small Bowel Injury in Dual Antiplatelet Therapy.Internal medicine (Tokyo, Japan) · 2021Article
- Non-steroidal anti-inflammatory drug-induced enteropathy as a major risk factor for small bowel bleeding: a retrospective study.BMC gastroenterology · 2020Article
- Small-Bowel Lesions in Patients Taking Direct Oral Anticoagulants Detected Using Capsule Endoscopy.Gastroenterology research and practice · 2020Article
- Identification of intestinal abnormalities in patients with active pulmonary tuberculosis using small bowel capsule endoscopy.Endoscopy international open · 2018Article
- Characteristics of Nonsteroidal Anti-Inflammatory Drugs (NSAIDs)-Induced Small Bowel Injury Identified by Single-Balloon Endoscopy or Capsule Endoscopy.Medical science monitor : international medical journal of experimental and clinical research · 2017Article
- Is duodenal biopsy appropriate in areas endemic forNorthern clinics of Istanbul · 2017Article
- In vitro evidence that phosphatidylcholine protects against indomethacin/bile acid-induced injury to cells.American journal of physiology. Gastrointestinal and liver physiology · 2015Article
- A Small Bowel Ulcer due to Clopidogrel with Cytomegalovirus Enteritis Diagnosed by Capsule and Double-Balloon Endoscopy.Case reports in gastroenterologyArticle
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo investigate the clinical differences between small intestinal injuries in low-dose aspirin (LDA) users and in non-steroidal anti-inflammatory drug (NSAID) users who were examined by capsule endoscopy (CE) for obscure gastrointestinal bleeding (OGIB).
methodsA total of 181 patients who underwent CE for OGIB were included in this study. Based on clinical records, laboratory data such as hemoglobin levels, major symptoms, underlying diseases, the types and duration of LDA and NSAID use, and endoscopic characteristics of CE were reviewed.
resultsOut of a total of 45 cases of erosive lesions, 27 cases were taking LDA or NSAIDs (7 were on NSAIDs, 9 were on LDA alone, 9 were on LDA and thienopyridine, and 2 were on LDA and warfarin).The prevalence of ulcers or erosion during chronic use of LDA, LDA and the anti-platelet drug thienopyridine (clopidogrel or ticlopidine), and NSAIDs were 64.3%, 80.0%, and 75.0%, respectively. Erosive lesions were observed predominantly in chronic LDA users, while ulcerative lesions were detected mainly in NSAID users. However, concomitant use of thienopyridine such as clopidogrel with LDA increased the proportion of ulcers. The erosive lesions were located in the whole of the small intestine (jejunum and ileum), whereas ulcerative lesions were mainly observed in the ileum (P < 0.05).
conclusionOur CE findings indicate that chronic LDA users and NSAID users show different types and locations of small-bowel mucosal injuries. The concomitant use of anti-platelet drugs with LDA tends to exacerbate the injuries from LDA-type to NSAID-type injuries.
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