Evidence map›Paper›PMID 25278578›Full record

ReviewClinical microbiology reviews2014

Microbiology, genomics, and clinical significance of the Pseudomonas fluorescens species complex, an unappreciated colonizer of humans.

Brittan S Scales, Robert P Dickson, John J LiPuma, Gary B Huffnagle

Registry-linked trialAbstract readReview
In one paragraph

Review in Clinical microbiology reviews, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02392182 (Understanding the Lung Microbiome in HIV-Infected & HIV-Uninfected Individuals), which is not on this map. Cited by 122 papers.

0numbers the graph read from it
0cells of the map it votes in
122citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02392182 completednot on this map

Understanding the Lung Microbiome in HIV-Infected & HIV-Uninfected Individuals

TypeobservationalSponsorUniversity of MichiganRan2009 to 2015Enrolled59ConditionsHealthy Participants, Tobacco Use Disorder, Human MicrobiomeArmsFiberoptic bronchoscopy
3 · Its place in the literature

Who cites it

122 citing papers in PubMed.

  1. Establishment of anmSystems · 2026
    Article
  2. Drought Stress Mediated Changes in Food Crops: Mechanisms and Remediation Strategies.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  3. Beyond the Usual Suspects: EmergingInternational journal of molecular sciences · 2026
    Review
  4. Article
  5. Article
  6. Article
  7. Microorganisms · 2026
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Inactivation of airborne pathogen surrogates by triethylene glycol.Applied and environmental microbiology · 2026
    Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Foods (Basel, Switzerland) · 2025
    Review
  19. Article
  20. Article

62 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Brittan S ScalesDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan, USA Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan, USA.
Robert P DicksonDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan, USA.
John J LiPumaDepartment of Pediatrics and Communicable Diseases, University of Michigan Medical School, Ann Arbor, Michigan, USA.
Gary B HuffnagleDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan, USA Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan, USA ghuff@umich.edu.

Funding

PULMONARY CELLULAR AND MOLECULAR BIOLOGY TRAININGT32HL007749 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Robert Pickett Dickson · 1993 to 2026
$19.9M
Molecular Mechanisms of Microbial Pathogenesis Training ProgramT32AI007528 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CARRUTHERS, VERNON BRUCE · 1998 to 2024
$6.8M
Understanding the Lung Microbiome in HIV-Infected and HIV-uninfected individualsU01HL098961 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BECK, JAMES M, CURTIS, JEFFREY LOUIS · 2009 to 2013
$3.6M
Pulmonary bacterial microbiome-epithelial cell interactions in COPDR01HL114447 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HUFFNAGLE, GARY B, MARTINEZ, FERNANDO J · 2012 to 2015
$1.5M
The Role of the Microbiome in the Acute Respiratory Distress SyndromeK23HL130641 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DICKSON, ROBERT PICKETT · 2016 to 2020
$859k
NHLBI NIH HHS K23 HL130641NHLBI NIH HHS L30 HL120241NHLBI NIH HHS R01 HL114447NHLBI NIH HHS R01HL114447NHLBI NIH HHS T32 HL007749NHLBI NIH HHS T32HL00774921NHLBI NIH HHS U01 HL098961NHLBI NIH HHS U01HL098961NIAID NIH HHS T32 AI007528NIAID NIH HHS T32AI007528
6 · The paper itself

Abstract

Pseudomonas fluorescens is not generally considered a bacterial pathogen in humans; however, multiple culture-based and culture-independent studies have identified it at low levels in the indigenous microbiota of various body sites. With recent advances in comparative genomics, many isolates originally identified as the "species" P. fluorescens are now being reclassified as novel Pseudomonas species within the P. fluorescens "species complex." Although most widely studied for its role in the soil and the rhizosphere, P. fluorescens possesses a number of functional traits that provide it with the capability to grow and thrive in mammalian hosts. While significantly less virulent than P. aeruginosa, P. fluorescens can cause bacteremia in humans, with most reported cases being attributable either to transfusion of contaminated blood products or to use of contaminated equipment associated with intravenous infusions. Although not suspected of being an etiologic agent of pulmonary disease, there are a number of reports identifying it in respiratory samples. There is also an intriguing association between P. fluorescens and human disease, in that approximately 50% of Crohn's disease patients develop serum antibodies to P. fluorescens. Altogether, these reports are beginning to highlight a far more common, intriguing, and potentially complex association between humans and P. fluorescens during health and disease.

Indexed as

GenomicsHost-Pathogen InteractionsHumansPhenotypePseudomonas fluorescensPseudomonas InfectionsQuantitative Trait, HeritableVirulence FactorsVirulence Factors

Identifiers

PMID25278578
PMCPMC4187640

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.