Evidence map›Paper›PMID 25278548›Full record

ArticleClinical journal of the American Society of Nephrology : CJASN2014

Associations of self-reported physical activity types and levels with quality of life, depression symptoms, and mortality in hemodialysis patients: the DOPPS.

Antonio Alberto Lopes, Brett Lantz, Hal Morgenstern, Mia Wang, Brian A Bieber, Brenda W Gillespie, Yun Li, Patricia Painter, Stefan H Jacobson, Hugh C Rayner and 5 more

2 registry-linked trialsAbstract read
In one paragraph

Article in Clinical journal of the American Society of Nephrology : CJASN, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 71 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
71citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03663049 phase4unknown statusstarted 2018, after this paper: background citation

Trial of Statin Holiday in Patients Receiving Maintenance Dialysis

Ran2018Enrolled30Registered outcomes5Posted comparisons0ConditionsCardiovascular Diseases, ESRDArmsdiscontinue statin
Open the trial in the graph
NCT04525196 naunknown statusnot on this mapstarted 2021, after this paper: background citation

Physical Activity in Dialysis: Clinical and Biological Impact

TypeinterventionalSponsorElsanRan2021 to 2025Enrolled250ConditionsChronic Renal FailureArmsPhysical activity.
3 · Its place in the literature

Who cites it

71 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
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  5. Effect of hemodiafiltration on measured physical activity: primary results of the HDFIT randomized controlled trial.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2021
    Trial
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  10. Ten tips for the first hemodialysis sessions.Clinical kidney journal · 2026
    Review
  11. 67 national-level factors potentially related to the incidence of kidney replacement therapy across Europe.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2026
    Article
  12. Article
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  14. Physical activity and cardiorenal health-from associations to interventional studies.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2025
    Review
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11 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Antonio Alberto LopesDepartment of Internal Medicine, School of Medicine, Federal University of Bahia, Salvador, BA, Brazil;
Brett LantzArbor Research Collaborative for Health, Ann Arbor, Michigan; University of Michigan, Ann Arbor, Michigan;
Hal MorgensternArbor Research Collaborative for Health, Ann Arbor, Michigan; Departments of Epidemiology, Environmental Health Sciences, and Department of Urology, School of Medicine, University of Michigan, Ann Arbor, Michigan;
Mia WangArbor Research Collaborative for Health, Ann Arbor, Michigan;
Brian A BieberArbor Research Collaborative for Health, Ann Arbor, Michigan;
Brenda W GillespieArbor Research Collaborative for Health, Ann Arbor, Michigan; Biostatistics, School of Public Health and.
Yun LiArbor Research Collaborative for Health, Ann Arbor, Michigan; Biostatistics, School of Public Health and.
Patricia PainterDepartment of Physical Therapy, University of Utah, Salt Lake City, Utah;
Stefan H JacobsonDivision of Nephrology, Karolinska Institute, Danderyd Hospital, Stockholm, Sweden;
Hugh C RaynerDepartment of Renal Medicine, Birmingham Heartlands Hospital, Birmingham, United Kingdom;
Donna L MapesArbor Research Collaborative for Health, Ann Arbor, Michigan;
Raymond C VanholderNephrology, University Hospital, Gent, Belgium; and.
Takeshi HasegawaDivision of Nephrology, Department of Internal Medicine, Showa University Fujigaoka Hospital, Tokyo, Japan.
Bruce M RobinsonArbor Research Collaborative for Health, Ann Arbor, Michigan;
Ronald L PisoniArbor Research Collaborative for Health, Ann Arbor, Michigan;

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

objectivesPhysical activity has been associated with better health status in diverse populations, but the association in patients on maintenance hemodialysis is less established. Patient-reported physical activities and associations with mortality, health-related quality of life, and depression symptoms in patients on maintenance hemodialysis in 12 countries were examined. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: In total, 5763 patients enrolled in phase 4 of the Dialysis Outcomes and Practice Patterns Study (2009-2011) were classified into five aerobic physical activity categories (never/rarely active to very active) and by muscle strength/flexibility activity using the Rapid Assessment of Physical Activity questionnaire. The Kidney Disease Quality of Life scale was used for health-related quality of life. The Center for Epidemiologic Studies Depression scale was used for depression symptoms. Linear regression was used for associations of physical activity with health-related quality of life and depression symptoms scores. Cox regression was used for association of physical activity with mortality.

resultsThe median (interquartile range) of follow-up was 1.6 (0.9-2.5) years; 29% of patients were classified as never/rarely active, 20% of patients were classified as very active, and 20.5% of patients reported strength/flexibility activities. Percentages of very active patients were greater in clinics offering exercise programs. Aerobic activity, but not strength/flexibility activity, was associated positively with health-related quality of life and inversely with depression symptoms and mortality (adjusted hazard ratio of death for very active versus never/rarely active, 0.60; 95% confidence interval, 0.47 to 0.77). Similar associations with aerobic activity were observed in strata of age, sex, time on dialysis, and diabetes status.

conclusionsThe findings are consistent with the health benefits of aerobic physical activity for patients on maintenance hemodialysis. Greater physical activity was observed in facilities providing exercise programs, suggesting a possible opportunity for improving patient outcomes.

Indexed as

Motor ActivityQuality of LifeRenal DialysisSelf ReportAgedAged, 80 and overAustraliaCanadaDepressionEuropeFemaleHealth StatusHumansJapanLinear ModelsMaledepressionhemodialysismortalityoutcomes

Identifiers

PMID25278548
PMCPMC4186524

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.