Evidence map›Paper›PMID 25278311›Full record

ReviewPancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]

Role of pancreatic fat in the outcomes of pancreatitis.

Chathur Acharya, Sarah Navina, Vijay P Singh

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 2 pooled it
5.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 2 syntheses or guidelines pooled it, 89 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. Article
  9. Prevalence of Pancreatic Steatosis and Its Associated Factors in Turkey: A Nation-Wide Multicenter Study.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2024
    Article
  10. Article
  11. Relationship of circulating levels of long-chain fatty acids to persistent organ failure in acute pancreatitis.American journal of physiology. Gastrointestinal and liver physiology · 2023
    Article
  12. Observational
  13. Review
  14. Article
  15. Observational
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Chathur AcharyaDepartment of Medicine, Virginia Commonwealth University, Richmond, VA, USA.
Sarah NavinaClin-Path Associates, Tempe, AZ, USA.
Vijay P SinghDepartment of Medicine, Mayo Clinic, Scottsdale, AZ, USA. Electronic address: singh.vijay@mayo.edu.
Mayo Clinic in Arizona · USVirginia Commonwealth University · US

Funding

University of Pittsburgh Clinical and Translational Science InstituteUL1TR000005 · NCATS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI REIS, STEVEN E · 2012 to 2015
$50.8M
Obesity related pancreatic fat worsens local injury via unsaturated fatty acidsR01DK092460 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SINGH, VIJAY PREM · 2011 to 2024
$5.5M
NCATS NIH HHS UL1 TR000005NIDDK NIH HHS R01 DK092460NIDDK NIH HHS R01DK092460
6 · The paper itself

Abstract

The role of obesity in relation to various disease processes is being increasingly studied, with reports over the last several years increasingly mentioning its association with worse outcomes in acute disease. Obesity has also gained recognition as a risk factor for severe acute pancreatitis (SAP).The mortality in SAP may be as high as 30% and is usually attributable to multi system organ failure (MSOF) earlier in the disease, and complications of necrotizing pancreatitis later [9-11]. To date there is no specific treatment for acute pancreatitis (AP) and the management is largely expectant and supportive. Obesity in general has also been associated with poor outcomes in sepsis and other pathological states including trauma and burns. With the role of unsaturated fatty acids (UFA) as propagators in SAP having recently come to light and with the recognition of acute lipotoxicity, there is now an opportunity to explore different strategies to reduce the mortality and morbidity in SAP and potentially other disease states associated with such a pathophysiology. In this review we will discuss the role of fat and implications of the consequent acute lipotoxicity on the outcomes of acute pancreatitis in lean and obese states and during acute on chronic pancreatitis.

Indexed as

Intra-Abdominal FatAcute DiseaseHumansMultiple Organ FailureObesityPancreasPancreatitisPancreatitis, Acute NecrotizingPancreatitis, ChronicSeverity of Illness IndexFibrosisLipotoxicityMulti system organ failureObesityOutcomesPancreatitis

Identifiers

PMID25278311
PMCPMC4185152
OpenAlexW2168828250

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.