Evidence map›Paper›PMID 25278190›Full record

ArticleBrain research2014

Mu-opioid receptor (MOR) expression in the human spiral ganglia.

Kimanh D Nguyen, Donald Mowlds, Ivan A Lopez, Seiji Hosokawa, Akira Ishiyama, Gail Ishiyama

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.7field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 19 citations in OpenAlex.

  1. Histopathology of Opioid-Induced Sensorineural Hearing Loss: A Case Report.Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology · 2025
    Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Immunohistochemical techniques for the human inner ear.Histochemistry and cell biology · 2016
    Review
  9. Noise-induced hearing loss: Neuropathic pain via Ntrk1 signaling.Molecular and cellular neurosciences · 2016
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Kimanh D NguyenDepartment of Head and Neck Surgery, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90024, USA.
Donald MowldsNeurology Department, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90024, USA.
Ivan A LopezDepartment of Head and Neck Surgery, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90024, USA.
Seiji HosokawaDepartment of Head and Neck Surgery, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90024, USA.
Akira IshiyamaDepartment of Head and Neck Surgery, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90024, USA.
Gail IshiyamaNeurology Department, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90024, USA. Electronic address: gishiyama@mednet.ucla.edu.
University of California, Los Angeles · US

Funding

The Role of Striosome Neurons in Mediating Opiod RewardP50DA005010 · NIDA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WALWYN, WENDY M · 1987 to 2021
$30.7M
The Otopathology of Hearing Loss: Genotype-Phenotype Correlation in Human TBU24DC011962 · NIDCD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ISHIYAMA, AKIRA, LINTHICUM, FRED H · 2011 to 2015
$2.2M
Modern Studies of the Human Temporal BoneU24DC008635 · NIDCD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ISHIYAMA, AKIRA · 2006 to 2010
$2.0M
Mechanism of Opiate Induced Audiovestibular DysfunctionK08DC005187 · NIDCD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ISHIYAMA, GAIL P · 2002 to 2006
$912k
NIDA NIH HHS DA05010NIDA NIH HHS P50 DA005010NIDCD NIH HHS 5U24DC008635NIDCD NIH HHS DC05187-0NIDCD NIH HHS K08 DC005187NIDCD NIH HHS U24 DC008635NIDCD NIH HHS U24 DC011962
6 · The paper itself

Abstract

Opioid peptides and their receptors have been localized to the inner ear of the rat and guinea pig mammalian models. The expression of mu opioid receptor (MOR) in the human and mouse cochlea is not yet known. We present MOR protein localization by immunohistochemistry and mRNA expression by in situ hybridization in the human and mouse spiral ganglia (SG) and organ of Corti. In the human most of the (SG) neurons were immunoreactive; a subset was non-immunoreactive. In situ hybridization revealed a similar labeling pattern across the neurons of the SG. A similar distribution MOR pattern was demonstrated in the mouse SG. In the mouse organ of Corti MOR was expressed in inner and outer hair cells. Fibers underneath the inner hair cells were also MOR immunoreactive. These results are consistent with a role of MOR in neuromodulation of the auditory periphery. The present results show that the expression of MORs is well-conserved across multiple mammalian species, indicative of an important role in auditory processing.

Indexed as

AgedAged, 80 and overAnimalsAutopsyCochleaHumansMaleMiceMice, Inbred C57BLNeuronsReceptors, Opioid, muRNA, MessengerSpiral GanglionTemporal BoneReceptors, Opioid, muRNA, MessengerAfferent terminalsCochleaNeuropeptidesOpioid receptorsSpiral ganglia neurons

Identifiers

PMID25278190
PMCPMC4437724
OpenAlexW2073077545

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.