ReviewAgeing research reviews2014
BioAge: toward a multi-determined, mechanistic account of cognitive aging.
Review in Ageing research reviews, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed.
- Exploring epigenetic aging and cognitive change in middle adulthood.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026Article
- Comparison of the additive value of blood-based and retinal biomarkers to clinical features in predicting cognitive decline.Communications medicine · 2025Article
- Association of estimated glucose disposition rate with aging acceleration and mortality risk in individuals with cardiovascular-kidney-metabolic syndrome: evidence from two large national population-based studies.Cardiovascular diabetology · 2025Article
- Epigenetic Age Acceleration and Chronological Age: Associations With Cognitive Performance in Daily Life.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024Article
- Data-Driven Analyses of Longitudinal Hippocampal Imaging Trajectories: Discrimination and Biomarker Prediction of Change Classes.Journal of Alzheimer's disease : JAD · 2022Article
- Vaccination as a preventative measure contributing to immune fitness.NPJ vaccines · 2021Review
- Method and Computer System for Dialog Optimization of Aging Biomarker Panels for Biological Age Assessment.Frontiers in genetics · 2021Article
- T1-weighted MRI-driven Brain Age Estimation in Alzheimer's Disease and Parkinson's Disease.Aging and disease · 2020Article
- Interplay between Nutrition and Hearing Loss: State of Art.Nutrients · 2018Review
- Klotho controls the brain-immune system interface in the choroid plexus.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- The association between "Brain-Age Score" (BAS) and traditional neuropsychological screening tools in Alzheimer's disease.Brain and behavior · 2018Article
- Memory Resilience to Alzheimer's Genetic Risk: Sex Effects in Predictor Profiles.The journals of gerontology. Series B, Psychological sciences and social sciences · 2017Article
- Youthful Processing Speed in Older Adults: Genetic, Biological, and Behavioral Predictors of Cognitive Processing Speed Trajectories in Aging.Frontiers in aging neuroscience · 2017Article
- Vascular Health and Genetic Risk Affect Mild Cognitive Impairment Status and 4-Year Stability: Evidence From the Victoria Longitudinal Study.The journals of gerontology. Series B, Psychological sciences and social sciences · 2016Article
- Changes in Frailty Predict Changes in Cognition in Older Men: The Honolulu-Asia Aging Study.Journal of Alzheimer's disease : JAD · 2016Article
- Exergame and Balance Training Modulate Prefrontal Brain Activity during Walking and Enhance Executive Function in Older Adults.Frontiers in aging neuroscience · 2016Article
- FDG-PET Contributions to the Pathophysiology of Memory Impairment.Neuropsychology review · 2015Review
- Epigenetic age acceleration and cognitive performance over time in older adults.Alzheimer's & dementia (Amsterdam, Netherlands)Article
- Accelerated biological aging is associated with cognitive performance among older adults in Mexico, India, United States, and England: A cross-national analysis.Alzheimer's & dementia (Amsterdam, Netherlands)Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
The search for reliable early indicators of age-related cognitive decline represents a critical avenue for progress in aging research. Chronological age is a commonly used developmental index; however, it offers little insight into the mechanisms underlying cognitive decline. In contrast, biological age (BioAge), reflecting the vitality of essential biological systems, represents a promising operationalization of developmental time. Current BioAge models have successfully predicted age-related cognitive deficits. Research on aging-related cognitive function indicates that the interaction of multiple risk and protective factors across the human lifespan confers individual risk for late-life cognitive decline, implicating a multi-causal explanation. In this review, we explore current BioAge models, describe three broad yet pathologically relevant biological processes linked to cognitive decline, and propose a novel operationalization of BioAge accounting for both moderating and causal mechanisms of cognitive decline and dementia. We argue that a multivariate and mechanistic BioAge approach will lead to a greater understanding of disease pathology as well as more accurate prediction and early identification of late-life cognitive decline.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.