ArticleOsteoarthritis and cartilage2014
Synovial pathology detected on ultrasound correlates with the severity of radiographic knee osteoarthritis more than with symptoms.
Article in Osteoarthritis and cartilage, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.
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Who cites it
37 citing papers in PubMed, 1 synthesis or guideline pooled it, 82 citations in OpenAlex.
- Synovial changes detected by ultrasound in people with knee osteoarthritis - a meta-analysis of observational studies.Osteoarthritis and cartilage · 2016Pooled it
- Musculoskeletal ultrasound in symptomatic thumb-base osteoarthritis: clinical, functional, radiological and muscle strength associations.BMC musculoskeletal disorders · 2019Trial
- Knee pain and related health in the community study (KPIC): a cohort study protocol.BMC musculoskeletal disorders · 2017Trial
- An international multi-centre prospective study on the efficacy of an intraarticular polyacrylamide hydrogel in horses with osteoarthritis: a 24 months follow-up.Acta veterinaria Scandinavica · 2015Trial
- Effusion and synovial hyperplasia: Distinct constructs in early and late-stage knee OA.Osteoarthritis imaging · 2026Article
- Optical Spectral Transmission Imaging in Patients with Osteoarthritis: A Comparative Study with Joint Ultrasound and Clinical Markers.Rheumatology and therapy · 2026Article
- Osteoarthritis: Epidemiology, Diagnosis, and Treatment.MedComm · 2026Review
- The frequency and severity of ultrasound-detected osteoarthritis features in the knees and their associations with pain: Cross-sectional analyses of the Nor-Hand study.Osteoarthritis and cartilage open · 2025Article
- Biomarker-Guided Imaging and AI-Augmented Diagnosis of Degenerative Joint Disease.Diagnostics (Basel, Switzerland) · 2025Review
- Imaging-based measures of synovitis in knee osteoarthritis: A scoping review and narrative synthesis.Osteoarthritis and cartilage open · 2025Review
- Bidirectional association identified between synovitis and knee and hand osteoarthritis: a general population-based study.The Lancet regional health. Western Pacific · 2024Article
- Specific-cytokine associations with outcomes in knee osteoarthritis subgroups: breaking down disease heterogeneity with phenotyping.Arthritis research & therapy · 2024Article
- The ultrasound assessment of osteoarthritis: the current status.Skeletal radiology · 2023Review
- RNA-Seq Reveals the mRNAs, miRNAs, and lncRNAs Expression Profile of Knee Joint Synovial Tissue in Osteoarthritis Patients.Journal of clinical medicine · 2023Article
- Establishment of an ultrasound-guided protocol for the assessment of hip joint osteoarthritis in rabbits-A sonoanatomic study.PloS one · 2023Article
- Construct validity of a clinically correlated knee osteoarthritis ultrasonographic scale: a cross-sectional observational study.BMJ open · 2021Observational
- Ultrasonography findings in knee osteoarthritis: a prospective observational cross-sectional study of 100 patients.Scientific reports · 2021Observational
- Prevalence of ultrasound-detected knee synovial abnormalities in a middle-aged and older general population-the Xiangya Osteoarthritis Study.Arthritis research & therapy · 2021Article
- Machine Learning in Rheumatic Diseases.Clinical reviews in allergy & immunology · 2021Review
- An Efficient CNN for Hand X-Ray Classification of Rheumatoid Arthritis.Journal of healthcare engineering · 2021Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveTo [1] compare the frequency and severity of ultrasound (US) features in people with normal knees (controls), knee pain (KP), asymptomatic radiographic OA (ROA), and symptomatic OA (SROA), [2] examine relationships between US features, pain and radiographic severity, [3] explore the relationship between change in pain and US features over a 3-month period.
methodCommunity participants were recruited into a multiple group case-control study. All underwent assessment for pain, knee radiographs and US examination for effusion, synovial hypertrophy, popliteal cysts and power Doppler (PD) signal within the synovium. A 3-month follow-up was undertaken in over half of control and SROA participants.
results243 participants were recruited (90 controls; 59 KP; 32 ROA; 62 SROA). Effusion and synovial hypertrophy were more common in ROA and SROA participants. Severity of effusion and synovial hypertrophy were greater in SROA compared to ROA (P < 0.05). Severity of US effusion and synovial hypertrophy were correlated with radiographic severity (r = 0.6 and r = 0.7, P < 0.01) but the relationship between pain severity and US features was weak (r = 0.3, P < 0.01). In SROA participants, pain severity did not change in tandem with a change in synovial hypertrophy over time.
conclusionUS abnormalities are common in OA. Effusion and synovial hypertrophy were moderately correlated with radiographic severity but the relationship with pain is less strong. The degree to which these features reflect "active inflammation" is questionable and they may be better considered as part of the total organ pathology in OA. Further studies are warranted to confirm these findings.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.