ArticleOsteoarthritis and cartilage2014
Rapid, automated imaging of mouse articular cartilage by microCT for early detection of osteoarthritis and finite element modelling of joint mechanics.
Article in Osteoarthritis and cartilage, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
51 citing papers in PubMed, 104 citations in OpenAlex.
- Micro-CT-based analysis of the murine osteochondral unit: a review and recommendations for standardized subchondral bone assessment.JBMR plus · 2026Review
- A validated SSAM-FEA framework for the rat knee reproduces varus-induced contact redistribution in a meniscus-deficient setting.Frontiers in bioengineering and biotechnology · 2026Article
- Femur Shape Changes in Prg4-Deficient Mice: Morphological Insights Into Joint Well-Being.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025Article
- Morphometric analysis of rat and mouse musculoskeletal tissues using high field MRI.Scientific reports · 2025Article
- Longitudinal assessment of structural and locomotor deficits as a prediction of severity in the collagenase-induced mouse model of osteoarthritis.Arthritis research & therapy · 2025Article
- Single-cell transcriptomics reveals novel chondrocyte and osteoblast subtypes and their role in knee osteoarthritis pathogenesis.Signal transduction and targeted therapy · 2025Article
- Phosphotungstic acid-enhanced micro-computed tomography and RNA sequencing provide a new perspective on temporomandibular joint arthritis induced by complete Freund's adjuvant and collagen-induced arthritis in rat models.Journal of dental sciences · 2025Article
- Observation of the Effects of Infrapatellar Fat Pad Excision on the Inflammatory Progression of Knee Osteoarthritis in Mice.Journal of inflammation research · 2025Article
- Effects of different combinations of mechanical loading intensity, duration, and frequency on the articular cartilage in mice.Molecular biology reports · 2024Article
- Article
- Mechanical Signal Transduction: A Key Role of Fluid Shear Forces in the Development of Osteoarthritis.Journal of inflammation research · 2024Review
- A synoptic literature review of animal models for investigating the biomechanics of knee osteoarthritis.Frontiers in bioengineering and biotechnology · 2024Review
- Mechanical overloading leads to chondrocyte degeneration and senescence via Zmpste24-mediated nuclear membrane instability.iScience · 2023Article
- Towards a Transferable Modeling Method of the Knee to Distinguish Between Future Healthy Joints from Osteoarthritic Joints: Data from the Osteoarthritis Initiative.Annals of biomedical engineering · 2023Article
- Development and experimental validation of a dynamic numerical model for human articular cartilage.Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine · 2023Article
- Evaluation of a lanthanide nanoparticle-based contrast agent for microcomputed tomography of porous channels in subchondral bone.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2023Article
- Contrast-enhanced micro-computed tomography of compartment and time-dependent changes in femoral cartilage and subchondral plate in a murine model of osteoarthritis.Anatomical record (Hoboken, N.J. : 2007) · 2023Article
- Article
- In vitro method to quantify and visualize mechanical wear in human meniscus subjected to joint loading.Journal of the mechanical behavior of biomedical materials · 2022Article
- Structural features of subchondral bone cysts and adjacent tissues in hip osteoarthritis.Osteoarthritis and cartilage · 2022Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveMouse articular cartilage (AC) is mostly assessed by histopathology and its mechanics is poorly characterised. In this study: (1) we developed non-destructive imaging for quantitative assessment of AC morphology and (2) evaluated the mechanical implications of AC structural changes.
methodsKnee joints obtained from naïve mice and from mice with osteoarthritis (OA) induced by destabilization of medial meniscus (DMM) for 4 and 12 weeks, were imaged by phosphotungstic acid (PTA) contrast enhanced micro-computed tomography (PTA-CT) and scored by conventional histopathology. Our software (Matlab) automatically segmented tibial AC, drew two regions centred on each tibial condyle and evaluated the volumes included. A finite element (FE) model of the whole mouse joint was implemented to evaluate AC mechanics.
resultsOur method achieved rapid, automated analysis of mouse AC (structural parameters in <10 h from knee dissection) and was able to localise AC loss in the central region of the medial tibial condyle. AC thickness decreased by 15% at 4 weeks and 25% at 12 weeks post DMM surgery, whereas histopathology scores were significantly increased only at 12 weeks. FE simulations estimated that AC thinning at early-stages in the DMM model (4 weeks) increases contact pressures (+39%) and Tresca stresses (+43%) in AC.
conclusionPTA-CT imaging is a fast and simple method to assess OA in murine models. Once applied more extensively to confirm its robustness, our approach will be useful for rapidly phenotyping genetically modified mice used for OA research and to improve the current understanding of mouse cartilage mechanics.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.